Human IL-4 Quantikine HS ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-4 (Interleukin-4) is a cytokine that is primarily expressed by Th2-biased CD4+ T cells, mast cells, basophils, and eosinophils. It promotes cell proliferation, survival, and immunoglobulin class switch to IgG4 and IgE in human B cells, acquisition of the Th2 phenotype by naïve CD4+ T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells. IL-4 plays a dominant role in the development of allergic inflammation and asthma. The type I receptor for IL-4, which is expressed on hematopoietic cells, is a heterodimer of the ligand binding IL-4 R? and the common ? chain (a shared subunit of the receptors for IL-2, -7, -9, -15, and -21). The type II receptor on nonhematopoietic cells consists of IL-4 R? and IL-13 R?1. The type II receptor also transduces IL-13 mediated signals.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 10 of 28. Show All 28 Publications. Collapse Publications.

Publications using HS400	Applications	Species
Neubauer-Geryk, J;Wielicka, M;My?liwiec, M;Zorena, K;Bieniaszewski, L; The Impact of Metabolic Memory on Immune Profile in Young Patients with Uncomplicated Type 1 Diabetes International journal of molecular sciences 2024-03-10 [PMID: 38542165] (Human)		Human
Sun, Y;Chen, D;Dai, T;Yu, Z;Xie, H;Wang, X;Zhang, W; Cell-free fat extract promotes axon regeneration and retinal ganglion cells survival in traumatic optic neuropathy Frontiers in cellular neuroscience 2024-03-07 [PMID: 38515790] (Human)		Human
Oliveras-Cañellas, N;Castells-Nobau, A;de la Vega-Correa, L;Latorre-Luque, J;Motger-Albertí, A;Arnoriaga-Rodriguez, M;Garre-Olmo, J;Zapata-Tona, C;Coll-Martínez, C;Ramió-Torrentà, L;Moreno-Navarrete, JM;Puig, J;Villarroya, F;Ramos, R;Casadó-Anguera, V;Martín-García, E;Maldonado, R;Mayneris-Perxachs, J;Fernández-Real, JM; Adipose tissue coregulates cognitive function Science advances 2023-08-11 [PMID: 37566655] (Human)		Human
Abramiuk, M;Frankowska, K;Ku?ak, K;Tarkowski, R;Mertowska, P;Mertowski, S;Grywalska, E; Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis International journal of molecular sciences 2023-04-24 [PMID: 37175494] (Human)		Human
J Po?omska, B Soza?ska Metabolites of L-ARG in Exhaled Breath Condensate and Serum Are Not Biomarkers of Bronchial Asthma in Children Journal of Clinical Medicine, 2022-01-04;11(1):. 2022-01-04 [PMID: 35011992] (Human)		Human
K Kurianowic, M Klatka, A Polak, A Hymos, D B?bnowska, M Podgajna, R Hrynkiewic, O Sierawska, P Nied?wiedz Impaired Innate Immunity in Pediatric Patients Type 1 Diabetes-Focus on Toll-like Receptors Expression International Journal of Molecular Sciences, 2021-11-09;22(22):. 2021-11-09 [PMID: 34830017] (Human)		Human
L Petrone, F Tamarozzi, A Vola, MA Gomez Mora, A Ludovisi, S Najafi Far, M Mariconti, E Brunetti, D Goletti Accuracy of an experimental whole-blood test for detecting reactivation of echinococcal cysts PloS Neglected Tropical Diseases, 2021-08-20;15(8):e0009648. 2021-08-20 [PMID: 34415898] (Human)		Human
Weng T, Huang S, Chuang Y, Wang J Effects of interval and continuous exercise training on CD4 lymphocyte apoptotic and autophagic responses to hypoxic stress in sedentary men. PLoS ONE, 2013-11-13;8(11):e80248. 2013-11-13 [PMID: 24236174] (Human)		Human
Suzukawa M, Nagase H, Ogahara I, Han K, Tashimo H, Shibui A, Koketsu R, Nakae S, Yamaguchi M, Ohta K Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils. J. Immunol., 2011-03-18;186(9):5254-60. 2011-03-18 [PMID: 21421855] (Human)		Human
Jun AS, Cope L, Speck C, Feng X, Lee S, Meng H, Hamad A, Chakravarti S Subnormal cytokine profile in the tear fluid of keratoconus patients. PLoS ONE, 2011-01-27;6(1):e16437. 2011-01-27 [PMID: 21298010] (Human)		Human
Darmanis S, Nong RY, Hammond M, Gu J, Alderborn A, Vanelid J, Siegbahn A, Gustafsdottir S, Ericsson O, Landegren U, Kamali-Moghaddam M Sensitive plasma protein analysis by microparticle-based proximity ligation assays. Mol. Cell Proteomics, 2009-11-27;9(2):327-35. 2009-11-27 [PMID: 19955079] (Human)		Human
Sadeghi M, Daniel V, Schnitzler P, Lahdou I, Naujokat C, Zeier M, Opelz G Urinary proinflammatory cytokine response in renal transplant recipients with polyomavirus BK viruria. Transplantation, 2009-11-15;88(9):1109-16. 2009-11-15 [PMID: 19898207] (Human)		Human
Ingvarsson J, Wingren C, Carlsson A, Ellmark P, Wahren B, Engstrom G, Harmenberg U, Krogh M, Peterson C, Borrebaeck CA Detection of pancreatic cancer using antibody microarray-based serum protein profiling. Proteomics, 2008-06-01;8(11):2211-9. 2008-06-01 [PMID: 18528842] (Human)		Human
Bozkurt FY, Yetkin Ay Z, Berker E, Tepe E, Akkus S Anti-inflammatory cytokines in gingival crevicular fluid in patients with periodontitis and rheumatoid arthritis: a preliminary report. Cytokine, 2006-09-18;35(3):180-5. 2006-09-18 [PMID: 16982199] (Human)		Human
Theurl I, Mattle V, Seifert M, Mariani M, Marth C, Weiss G Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease. Blood, 2006-01-24;107(10):4142-8. 2006-01-24 [PMID: 16434484] (Human)		Human
Yamanaka K, Clark R, Dowgiert R, Hurwitz D, Shibata M, Rich BE, Hirahara K, Jones DA, Eapen S, Mizutani H, Kupper TS Expression of interleukin-18 and caspase-1 in cutaneous T-cell lymphoma. Clin. Cancer Res., 2006-01-15;12(2):376-82. 2006-01-15 [PMID: 16428475] (Human)		Human
Huang JL, Huang J, Duan ZH, Wei J, Min J, Luo XH, Li JG, Tan WP, Wu LZ, Liu RY, Li Y, Shao J, Huang BJ, Zeng YX, Huang W Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome. Microbes Infect., 2005-02-24;7(3):427-36. 2005-02-24 [PMID: 15784184] (Human)		Human
Sadeghi M, Daniel V, Naujokat C, Wiesel M, Hergesell O, Opelz G Strong inflammatory cytokine response in male and strong anti-inflammatory response in female kidney transplant recipients with urinary tract infection. Transpl. Int., 2005-02-01;18(2):177-85. 2005-02-01 [PMID: 15691270] (Human)		Human
Jensen J, Krakauer M, Sellebjerg F Cytokines and adhesion molecules in multiple sclerosis patients treated with interferon-beta1b. Cytokine, 2005-01-07;29(1):24-30. 2005-01-07 [PMID: 15579375] (Human)		Human
Pitzurra L, Bellocchio S, Nocentini A, Bonifazi P, Scardazza R, Gallucci L, Stracci F, Simoncelli C, Bistoni F, Romani L Antifungal immune reactivity in nasal polyposis. Infect. Immun., 2004-12-01;72(12):7275-81. 2004-12-01 [PMID: 15557653] (Human)		Human
Attallah AM, Ibrahim GG Immunodetection of a hepatitis C virus (HCV) antigen and Thl/Th2 cytokines in cerebrospinal fluid of meningitis patients. J Immunoassay Immunochem, 2004-01-01;25(4):313-20. 2004-01-01 [PMID: 15552586] (Human)		Human
Bartosik-Psujek H, Stelmasiak Z Correlations between IL-4, IL-12 levels and CCL2, CCL5 levels in serum and cerebrospinal fluid of multiple sclerosis patients. J Neural Transm, 2004-10-12;112(6):797-803. 2004-10-12 [PMID: 15480850] (Human)		Human
Rosias PP, Dompeling E, Hendriks HJ, Heijnens JW, Donckerwolcke RA, Jobsis Q Exhaled breath condensate in children: pearls and pitfalls. Pediatr Allergy Immunol, 2004-02-01;15(1):4-19. 2004-02-01 [PMID: 14998377] (Human)		Human
Ewbank PA, Murray J, Sanders K, Curran-Everett D, Dreskin S, Nelson HS A double-blind, placebo-controlled immunotherapy dose-response study with standardized cat extract. J. Allergy Clin. Immunol., 2003-01-01;111(1):155-61. 2003-01-01 [PMID: 12532112] (Human)		Human
Hamzaoui K, Hamzaoui A, Guemira F, Bessioud M, Hamza M, Ayed K Cytokine profile in Behcet's disease patients. Relationship with disease activity. Scand. J. Rheumatol., 2002-01-01;31(4):205-10. 2002-01-01 [PMID: 12369651] (Human)		Human
Black , K P, Merrill , K W, Jackson , S, Katz , J Cytokine profiles in parotid saliva from HIV-1-infected individuals: changes associated with opportunistic infections in the oral cavity. Oral Microbiol Immunol, 2000-04-01;15(2):74-81. 2000-04-01 [PMID: 11155169] (Human)		Human
Rigano R, Profumo E, Bruschi F, Carulli G, Azzara A, Ioppolo S, Buttari B, Ortona E, Margutti P, Teggi A, Siracusano A Modulation of human immune response by Echinococcus granulosus antigen B and its possible role in evading host defenses. Infect. Immun., 2001-01-01;69(1):288-96. 2001-01-01 [PMID: 11119517] (Human)		Human
Benson M, Strannegard IL, Wennergren G, Strannegard O Low levels of interferon-gamma in nasal fluid accompany raised levels of T-helper 2 cytokines in children with ongoing allergic rhinitis. Pediatr Allergy Immunol, 2000-02-01;11(1):20-8. 2000-02-01 [PMID: 10768732] (Human)		Human
Show All 28 Publications. Collapse Publications.

Array HS400

• IL-4 Antibodies
• IL-4 ELISA Kits
• IL-4 Kit
• IL-4 Proteins
• IL-4 Proteins and Enzymes
• IL-4 ELISAs