Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Human CD31/PECAM-1 DuoSet ELISA, 5 Plate
adhesion molecule
CD31 antigen
CD31
CD31/EndoCAM
EndoCAM
FLJ34100
FLJ58394
GPIIA'
PECA1
PECAM1
PECAM-1
PECAM-1, CD31/EndoCAM
platelet endothelial cell adhesion molecule
platelet endothelial cell adhesion molecule-1
platelet/endothelial cell adhesion molecule
Background
CD31/PECAM-1 is a heavily glycosylated transmembrane homophilic adhesion protein that is highly expressed on endothelial cells and at a lower level on platelets, granulocytes, macrophages, dendritic cells, T and B cells, and NK cells. It is required for the transepithelial migration of leukocytes. CD31 signaling increases the activation threshold of T cells and inhibits dendritic cell development. The extracellular domain of CD31 is released during endothelial cell apoptosis. This fragment circulates in the serum of patients suffering from myocardial infarction, acute ischaemic stroke, and multiple sclerosis, conditions that involve tissue damage and endothelial cell apoptosis.