Human CD163 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CD163, also known as M130 and p155, is a transmembrane scavenger receptor that is expressed on monocytes and macrophages and is inducible by immunosuppressant glucocorticoids and IL-10. A soluble form is shed from the cell surface by TACE or neutrophil elastase mediated cleavage in response to oxidative stress, Prostaglandin F2a stimulation, or the activation of Fc gamma receptors, TLR1, 2, 5, or 6. CD163 mediates monocyte binding to bacteria, leading to the release of inflammatory cytokines. It is essential for the circulatory clearance of hemoglobin-haptoglobin (Hb-Hp) complexes as well as free hemoglobin. It can also mediate monocyte-erythroblast adhesion and promote erythroblast expansion. CD163 binds and internalizes the cytokine TWEAK, and the ratio of soluble CD163 to TWEAK in the plasma is elevated during atherosclerosis.

We have publications tested in 2 confirmed species: Human, Primate.

Showing Publications 1 - 10 of 44. Show All 44 Publications. Collapse Publications.

Publications using DC1630	Applications	Species
Wang, P;Yang, L;Dong, J;Liu, W;Xie, F;Lu, Y;Li, W; The sEVs miR-487a/Notch2/GATA3 axis promotes osteosarcoma lung metastasis by inducing macrophage polarization toward the M2-subtype Cancer cell international 2024-08-31 [PMID: 39217351] (Human)		Human
Guan, X;Hu, R;Choi, Y;Srivats, S;Nabet, BY;Silva, J;McGinnis, L;Hendricks, R;Nutsch, K;Banta, KL;Duong, E;Dunkle, A;Chang, PS;Han, CJ;Mittman, S;Molden, N;Daggumati, P;Connolly, W;Johnson, M;Abreu, DR;Cho, BC;Italiano, A;Gil-Bazo, I;Felip, E;Mellman, I;Mariathasan, S;Shames, DS;Meng, R;Chiang, EY;Johnston, RJ;Patil, NS; Anti-TIGIT antibody improves PD-L1 blockade through myeloid and Treg cells Nature 2024-02-28 [PMID: 38418879] (Human)		Human
Rocafort, M;Gootenberg, DB;Luévano, JM;Paer, JM;Hayward, MR;Bramante, JT;Ghebremichael, MS;Xu, J;Rogers, ZH;Munoz, AR;Okello, S;Kim, JH;Sentongo, R;Wagubi, R;Lankowski, A;Maruapula, S;Zhao, G;Handley, SA;Mosepele, M;Siedner, MJ;Kwon, DS; HIV-associated gut microbial alterations are dependent on host and geographic context Nature communications 2024-02-05 [PMID: 38316748] (Human)		Human
Lischka, J;Schanzer, A;de Gier, C;Greber-Platzer, S;Zeyda, M; Macrophage-associated markers of metaflammation are linked to metabolic dysfunction in pediatric obesity Cytokine 2023-09-18 [PMID: 37729736] (Human)		Human
Chow, FC;Mundada, NS;Abohashem, S;La Joie, R;Iaccarino, L;Arechiga, VM;Swaminathan, S;Rabinovici, GD;Epel, ES;Tawakol, A;Hsue, PY; Psychological stress is associated with arterial inflammation in people living with treated HIV infection Brain, behavior, and immunity 2023-06-25 [PMID: 37369339] (Human)		Human
Kawanaka, M;Nishino, K;Kawada, M;Ishii, K;Tanikawa, T;Katsumata, R;Urata, N;Nakamura, J;Suehiro, M;Haruma, K;Kawamoto, H; Soluble CD163 is a predictor of fibrosis and hepatocellular carcinoma development in nonalcoholic steatohepatitis BMC gastroenterology 2023-05-10 [PMID: 37165352] (Human)		Human
Y Zhu, MJ Webster, AK Walker, P Massa, FA Middleton, CS Weickert Increased prefrontal cortical cells positive for macrophage/microglial marker CD163 along blood vessels characterizes a neuropathology of neuroinflammatory schizophrenia Brain, Behavior, and Immunity, 2023-03-25;0(0):. 2023-03-25 [PMID: 36972743] (Human)		Human
Y Zhu, MJ Webster, AK Walker, P Massa, FA Middleton, CS Weickert Increased prefrontal cortical cells positive for macrophage/microglial marker CD163 along blood vessels characterizes a neuropathology of neuroinflammatory schizophrenia Brain, Behavior, and Immunity, 2023;0(0):. 2023 [PMID: 36972743] (Human)		Human
LP Kincer, SB Joseph, MM Gilleece, BM Hauser, S Sizemore, S Zhou, C Di Germani, H Zetterberg, D Fuchs, SG Deeks, S Spudich, M Gisslen, RW Price, R Swanstrom Rebound HIV-1 in cerebrospinal fluid after antiviral therapy interruption is mainly clonally amplified R5 T cell-tropic virus Nature Microbiology, 2023-01-30;8(2):260-271. 2023-01-30 [PMID: 36717718] (Human)		Human
S Lee, N van den Be, A Castley, M Divitini, M Knuiman, P Price, D Nolan, F Sanfilippo, G Dwivedi Long-Term Associations between Human Cytomegalovirus Antibody Levels with All-Cause Mortality and Cardiovascular Outcomes in an Australian Community-Based Cohort Viruses, 2022-11-29;14(12):. 2022-11-29 [PMID: 36560680] (Human)		Human
RO Ali, GM Quinn, R Umarova, JA Haddad, GY Zhang, EC Townsend, L Scheuing, KL Hill, M Gewirtz, S Rampertaap, SD Rosenzweig, AT Remaley, JM Han, V Periwal, H Cai, PJ Walter, C Koh, EB Levy, DE Kleiner, O Etzion, T Heller Longitudinal multi-omics analyses of the gut-liver axis reveals metabolic dysregulation in hepatitis C infection and cirrhosis Nature Microbiology, 2022-12-15;0(0):. 2022-12-15 [PMID: 36522461] (Human)		Human
J Parantaine, G Barreto, R Koivuniemi, H Kautiainen, D Nordström, E Moilanen, M Hämäläinen, M Leirisalo-, K Nurmi, KK Eklund The biological activity of serum bacterial lipopolysaccharides associates with disease activity and likelihood of achieving remission in patients with rheumatoid arthritis Arthritis Research & Therapy, 2022-11-21;24(1):256. 2022-11-21 [PMID: 36411473] (Human)		Human
P Zuccalà, T Latronico, R Marocco, S Savinelli, S Vita, F Mengoni, T Tieghi, C Borgo, B Kertusha, A Carraro, G D'Ettorre, V Vullo, CM Mastroiann, GM Liuzzi, M Lichtner Longitudinal Assessment of Multiple Immunological and Inflammatory Parameters during Successful DAA Therapy in HCV Monoinfected and HIV/HCV Coinfected Subjects International Journal of Molecular Sciences, 2022-10-08;23(19):. 2022-10-08 [PMID: 36233234] (Human)		Human
Y Hara, J Tsukiji, A Yabe, Y Onishi, H Hirose, M Yamamoto, M Kudo, T Kaneko, T Ebina Heme oxygenase-1 as an important predictor of the severity of COVID-19 PLoS ONE, 2022-08-24;17(8):e0273500. 2022-08-24 [PMID: 36001619] (Human)		Human
M Vassallo, J Durant, R Fabre, L Lotte, A Sindt, A Puchois, A De Monte, R Cezar, P Corbeau, C Pradier Inflammatory Markers after Switching to a Dual Drug Regimen in HIV-Infected Subjects: A Two-Year Follow-Up Viruses, 2022-04-28;14(5):. 2022-04-28 [PMID: 35632669] (Human)		Human
JS Pedersen, MO Rygg, K Chrøis, EG Sustarsic, Z Gerhart-Hi, NJ Wever Albr, RR Serizawa, VB Kristianse, AL Basse, AEB Boilesen, BH Olsen, T Hansen, LL Gluud, S Madsbad, S Larsen, F Bendtsen, F Dela Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration Nature Communications, 2022-05-25;13(1):2931. 2022-05-25 [PMID: 35614135] (Human)		Human
T Gilada, SR Schnittman, E White, J Mercader, Y Wang, S Dasgupta, R Valdez, D Pinto-Sant, S Pasalar, J Sanchez, P Gonzales, JR Lama, R Bender Ign, A Duerr Immune Activation in Primary Human Immunodeficiency Virus: Influence of Duration of Infection, Treatment, and Substance Use Open forum infectious diseases, 2022-03-24;9(6):ofac155. 2022-03-24 [PMID: 35611350] (Human)		Human
LC Alexander, G McHorse, JL Huebner, AC Bay-Jensen, MA Karsdal, VB Kraus A matrix metalloproteinase-generated neoepitope of CRP can identify knee and multi-joint inflammation in osteoarthritis Arthritis Research & Therapy, 2021-08-31;23(1):226. 2021-08-31 [PMID: 34465395] (Human)		Human
MC Mueller, WV Kern, S Usadel, MC Pauly, T Cathomen, U Salzer Assessing the differential impact of chronic CMV and treated HIV infection on CD8+ T-cell differentiation in a matched cohort study: is CMV the key? AIDS research and therapy, 2021-06-30;18(1):37. 2021-06-30 [PMID: 34193181] (Human)		Human
R Cezar, A Winter, D Desigaud, M Pastore, L Kundura, AM Dupuy, C Cognot, T Vincent, C Reynes, C Dunyach-Re, JP Lavigne, R Sabatier, P Le Merre, E Maggia, P Corbeau Identification of distinct immune activation profiles in adult humans Scientific Reports, 2020-11-30;10(1):20824. 2020-11-30 [PMID: 33257766] (Human)		Human
JP Magalhães, DA Santos, IR Correia, M Hetheringt, R Ribeiro, JF Raposo, A Matos, MD Bicho, LB Sardinha Impact of combined training with different exercise intensities on inflammatory and lipid markers in type 2 diabetes: a secondary analysis from a 1-year randomized controlled trial Cardiovasc Diabetol, 2020-10-07;19(1):169. 2020-10-07 [PMID: 33028418] (Human)		Human
LB Giron, F Colomb, E Papasavvas, L Azzoni, X Yin, M Fair, A Anzurez, M Damra, K Mounzer, JR Kostman, P Tebas, U O'Doherty, H Tateno, Q Liu, MR Betts, LJ Montaner, M Abdel-Mohs Interferon-alpha alters host glycosylation machinery during treated HIV infection EBioMedicine, 2020-08-19;59(0):102945. 2020-08-19 [PMID: 32827942] (Human)		Human
LB Giron, CE Tanes, MH Schleimann, PA Engen, LM Mattei, A Anzurez, M Damra, H Zhang, K Bittinger, F Bushman, A Kossenkov, PW Denton, H Tateno, A Keshavarzi, AL Landay, M Abdel-Mohs Sialylation and fucosylation modulate inflammasome-activating eIF2 Signaling and microbial translocation during HIV infection Mucosal Immunol, 2020-03-09;0(0):. 2020-03-09 [PMID: 32152415] (Human)		Human
JV Baker, J Wolfson, T Peterson, M Mooberry, M Gissel, H Mystakelis, MW Henderson, K Garcia-Mye, FS Rhame, TW Schacker, KE Brummel-Zi, I Sereti, NS Key, RP Tracy Factor Xa Inhibition Reduces Coagulation Activity but Not Inflammation Among People With HIV: A Randomized Clinical Trial Open Forum Infect Dis, 2020-02-01;7(2):ofaa026. 2020-02-01 [PMID: 32055640] (Human)		Human
Q Liu, Q Ou, H Chen, Y Gao, Y Liu, Y Xu, Q Ruan, W Zhang, L Shao Differential expression and predictive value of monocyte scavenger receptor CD163 in populations with different tuberculosis infection statuses BMC Infect. Dis., 2019-11-28;19(1):1006. 2019-11-28 [PMID: 31779590] (Human)		Human
G Guo, Y Zhu, Z Wu, H Ji, X Lu, Y Zhou, Y Li, X Cao, Y Lu, P Talbot, J Liao, Y Shi, H Bu Circulating monocytes accelerate acute liver failure by IL-6 secretion in monkey J. Cell. Mol. Med., 2018-07-11;0(0):. 2018-07-11 [PMID: 29992739] (Primate)		Primate
C Mascia, I Pozzetto, B Kertusha, R Marocco, C Del Borgo, T Tieghi, S Vita, S Savinelli, M Iannetta, V Vullo, M Lichtner, CM Mastroiann Persistent high plasma levels of sCD163 and sCD14 in adult patients with measles virus infection PLoS ONE, 2018-05-24;13(5):e0198174. 2018-05-24 [PMID: 29795672] (Human)		Human
T Fujimura, Y Sato, K Tanita, Y Kambayashi, A Otsuka, Y Fujisawa, K Yoshino, S Matsushita, T Funakoshi, H Hata, Y Yamamoto, H Uchi, Y Nonomura, R Tanaka, M Aoki, K Imafuku, H Okuhira, S Furudate, T Hidaka, S Aiba Serum levels of soluble CD163 and CXCL5 may be predictive markers for immune-related adverse events in patients with advanced melanoma treated with nivolumab: a pilot study Oncotarget, 2018-02-15;9(21):15542-15551. 2018-02-15 [PMID: 29643991] (Human)		Human
M Keshtkar-J, M Ouyang, M Keshtkarja, S Almed, H Li, JD Walston, R Rios, SX Leng Effect of influenza vaccine on tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in older adults Vaccine, 2018-03-13;0(0):. 2018-03-13 [PMID: 29548604] (Human)		Human
LR de Armas, S Pallikkuth, V George, S Rinaldi, R Pahwa, KL Arheart, S Pahwa Reevaluation of immune activation in the era of cART and an aging HIV-infected population JCI Insight, 2017-10-19;2(20):. 2017-10-19 [PMID: 29046481] (Human)		Human
SG Al-Kindi, DA Zidar, GA McComsey, CT Longenecke Association of Anisocytosis with Markers of Immune Activation and Exhaustion in Treated HIV Pathog Immun, 2017-05-02;2(1):138-150. 2017-05-02 [PMID: 28713869] (Human)		Human
C Mascia, S Vita, P Zuccalà, R Marocco, T Tieghi, S Savinelli, R Rossi, M Iannetta, I Pozzetto, C Furlan, F Mengoni, CM Mastroiann, V Vullo, M Lichtner Changes in inflammatory biomarkers in HCV-infected patients undergoing direct acting antiviral-containing regimens with or without interferon PLoS ONE, 2017-06-21;12(6):e0179400. 2017-06-21 [PMID: 28636655] (Human)		Human
PA Alvarado-V, L Bernal, CA Paige, RL Grosick, C Moracho Vi, DW Ferreira, C Ulecia-Mor, EA Romero-San Macrophage-specific nanotechnology-driven CD163 overexpression in human macrophages results in an M2 phenotype under inflammatory conditions Immunobiology, 2017-05-16;0(0):. 2017-05-16 [PMID: 28545809] (Human)		Human
M Kulkarni, E Bowman, J Gabriel, T Amburgy, E Mayne, DA Zidar, C Maierhofer, AN Turner, JA Bazan, SL Koletar, MM Lederman, SF Sieg, NT Funderburg Altered Monocyte and Endothelial Cell Adhesion Molecule Expression Is Linked to Vascular Inflammation in Human Immunodeficiency Virus Infection Open Forum Infect Dis, 2016-10-15;3(4):ofw224. 2016-10-15 [PMID: 28066794] (Human)		Human
Immune Activation at Sites of HIV/TB Co-Infection Contributes to the Pathogenesis of HIV-1 Disease PLoS ONE, 2016-11-21;11(11):e0166954. 2016-11-21 [PMID: 27870882] (Human)		Human
Ghislain M, Bastard J, Meyer L, Capeau J, Fellahi S, Gerard L, May T, Simon A, Vigouroux C, Goujard C Late Antiretroviral Therapy (ART) Initiation Is Associated with Long-Term Persistence of Systemic Inflammation and Metabolic Abnormalities. PLoS ONE, 2015-12-04;10(12):e0144317. 2015-12-04 [PMID: 26636578] (Human)		Human
Castley , Alison, Berry , Cassandr, French , Martyn, Fernandez , Sonia, Krueger , Romano, Nolan , David Elevated plasma soluble CD14 and skewed CD16+ monocyte distribution persist despite normalisation of soluble CD163 and CXCL10 by effective HIV therapy: a changing paradigm for routine HIV laboratory monitoring? PLoS ONE, 2014-12-29;9(12):e115226. 2014-12-29 [PMID: 25544986] (Human)		Human
Masia M, Robledano C, Ortiz de la Tabla V, Antequera P, Lumbreras B, Hernandez I, Gutierrez F Coinfection with human herpesvirus 8 is associated with persistent inflammation and immune activation in virologically suppressed HIV-infected patients. PLoS ONE, 2014-08-18;9(8):e105442. 2014-08-18 [PMID: 25133669] (Human)		Human
Beltran L, Munoz Hernandez R, de Pablo Bernal R, Garcia Morillo J, Egido J, Noval M, Ferrando-Martinez S, Blanco-Colio L, Genebat M, Villar J, Moreno-Luna R, Moreno J Reduced sTWEAK and increased sCD163 levels in HIV-infected patients: modulation by antiretroviral treatment, HIV replication and HCV co-infection. PLoS ONE, 2014-03-04;9(3):e90541. 2014-03-04 [PMID: 24594990] (Human)		Human
Zizzo G, Guerrieri J, Dittman L, Merrill J, Cohen P Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity. Arthritis Res Ther, 2013-01-01;15(6):R212. 2013-01-01 [PMID: 24325951] (Human)		Human
Forsvoll J, Kristoffersen E, Oymar K Elevated levels of CXCL10 in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome (PFAPA) during and between febrile episodes; an indication of a persistent activation of the innate immune system. Pediatr Rheumatol Online J, 2013-10-17;11(1):38. 2013-10-17 [PMID: 24134207] (Human)		Human
Subramanian K, Du R, Tan N, Ho B, Ding J CD163 and IgG codefend against cytotoxic hemoglobin via autocrine and paracrine mechanisms. J Immunol, 2013-04-15;190(10):5267-78. 2013-04-15 [PMID: 23589619] (Human)		Human
Shimizu M, Yachie A Compensated inflammation in systemic juvenile idiopathic arthritis: role of alternatively activated macrophages. Cytokine, 2012-06-08;60(1):226-32. 2012-06-08 [PMID: 22682876] (Human)		Human
Moreno JA, Dejouvencel T, Labreuche J, Smadja DM, Dussiot M, Martin-Ventura JL, Egido J, Gaussem P, Emmerich J, Michel JB, Blanco-Colio LM, Meilhac O Peripheral artery disease is associated with a high CD163/TWEAK plasma ratio. Arterioscler. Thromb. Vasc. Biol., 2010-03-18;30(6):1253-62. 2010-03-18 [PMID: 20299688] (Human)		Human
Show All 44 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer			01/07/2021	View Summary Sample Tested Citrate Plasma,Human serum,patient CSF Lot P251331

Array DC1630

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