| Reactivity | MuSpecies Glossary |
| Applications | WB |
| Clonality | Polyclonal |
| Host | Goat |
| Conjugate | Unconjugated |
| Concentration | LYOPH |
| Immunogen | E. coli-derived recombinant mouse HSF4 Gly343-Pro492 Accession # Q9R0L1 |
| Specificity | Detects mouse HSF4 in direct ELISAs and Western blots. In Western blots, approximately 25% cross‑reactivity with recombinant human (rh) HSF4 is observed and less than 5% cross-reactivity with recombinant mouse HSF1 and rhHSF2 is observed. |
| Source | N/A |
| Isotype | IgG |
| Clonality | Polyclonal |
| Host | Goat |
| Gene | HSF4 |
| Purity Statement | Antigen Affinity-purified |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
| Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
| Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
| Preservative | No Preservative |
| Concentration | LYOPH |
| Reconstitution Instructions | Reconstitute at 0.2 mg/mL in sterile PBS. |
HSF4 (heat shock factor 4) is a 55 kDa member of the HSF family of transcription factors. It is highly expressed in lens where it maintains lens integrity and blocks FGF synthesis. Mouse HSF4B is 492 amino acids in length. It contains one DNA binding region (aa 17‑122) and a Leu-zipper trimerization domain (hydrophobic repeat‑A/B) (aa 129‑203). Two additional potential isoforms exist. The first isoform, termed HSF4A, is transcriptionally inactive and shows a 45 aa substitution for aa 245‑319. The second isoform shows an 18 aa substitution for the first 78 amino acids of the N-terminus. Over aa 343‑492, mouse HSF4 shares 93% and 72% aa sequence identity with rat and human HSF4, respectively.
Secondary Antibodies |
Isotype Controls |
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