hnRNP U Antibody

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using NB100-2134	Applications	Species
Banerjee D, Mandal SM, Das A et al. Preferential repair of oxidized base damage in the transcribed genes of mammalian cells. J Biol Chem 2011-02-01 [PMID: 21169365]

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	Simple Western	Human	11/28/2019	View Summary Application Simple Western Sample Tested Human fibroblast and neural stem cells Species Human Lot A1 Comments Comments Dilution 1:100

Array NB100-2134

• hnRNP U Antibodies
• hnRNP U ELISA Kits
• hnRNP U Lysate
• hnRNP U Proteins