Orthogonal Strategies: Immunohistochemistry-Paraffin: GULP1/CED-6 Antibody [NBP1-84553] - Staining in human smooth muscle and tonsil tissues using anti-GULP1 antibody. Corresponding GULP1 RNA-seq data are ...read more
Western Blot: GULP1/CED-6 Antibody [NBP1-84553] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumor cells).
Immunocytochemistry/ Immunofluorescence: GULP1/CED-6 Antibody [NBP1-84553] - Staining of human cell line U-2 OS shows localization to vesicles. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: GULP1/CED-6 Antibody [NBP1-84553] - Staining of human smooth muscle shows high expression.
Immunohistochemistry-Paraffin: GULP1/CED-6 Antibody [NBP1-84553] - Staining of human tonsil shows low expression as expected.
This antibody was developed against Recombinant Protein corresponding to amino acids: KTDKRIFTFICKDSESNKHLCYVFDSEKCAEEITLTIGQAFDLAYRKFLESGGKDVETRKQIAGLQKRIQDLETENMELKNKVQDLENQLRITQVSA
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GULP1
Purity
Immunogen affinity purified
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Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified
Alternate Names for GULP1/CED-6 Antibody
CED6
CED6GULPCED-6
Cell death protein 6 homolog
engulfment adapter protein
FLJ31156
GULP, engulfment adaptor PTB domain containing 1
GULP1
Protein GULP
PTB domain adapter protein CED-6
PTB domain adaptor protein CED-6
PTB domain-containing engulfment adapter protein 1
Background
The prompt clearance of cells undergoing apoptosis is critical during embryonic development, normal tissue turnover, as well as inflammation and autoimmunity. CED6 and its human homologue gulp, encode an adapter protein, whose function in engulfment. The upstream and downstream components of CED6 mediated signaling are not known. Recently, CED1 has been shown to encode a transmembrane protein on phagocytic cells, with two functional sequence motifs in its cytoplasmic tail that are important for engulfment.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
FAQs for GULP1/CED-6 Antibody (NBP1-84553). (Showing 1 - 1 of 1 FAQs).
Is GULP1 localized to mitochondria?
I am showing based on localization data from UniProt that it may associate with the cytoplasmic side of the plasma membrane: http://www.uniprot.org/uniprot/Q9UBP9 Additional localization data may be found here at Human protein atlas: http://www.proteinatlas.org/ENSG00000144366
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