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GFR alpha-2/GDNF R alpha-2 Antibody (71515) [CoraFluor™ 1]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ICC/IF
Clone
71515
Clonality
Monoclonal
Host
Mouse
Conjugate
CoraFluor 1

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 532
FAB6131X
Allophycocyanin
FAB6131A
Biotin
FAB6131B
DyLight 350
FAB6131D
DyLight 405
FAB6131E
DyLight 488
FAB6131K
DyLight 550
FAB6131L
DyLight 594
FAB6131M
DyLight 650
FAB6131W
DyLight 680
FAB6131Y
DyLight 755
FAB6131Z
FITC
FAB6131F
HRP
FAB6131H
Janelia Fluor 525
FAB6131JF525
Janelia Fluor 549
FAB6131I
Janelia Fluor 646
FAB6131J
Janelia Fluor 669
FAB6131JF669
PE
FAB6131P
PerCP
FAB6131C
Unconjugated
MAB6131-100
mFluor Violet 450 SE
FAB6131MFV450
mFluor Violet 500 SE
FAB6131MFV500
mFluor Violet 610 SE
FAB6131MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB6131-100
Carrier Free
MAB6131-100
Carrier Free
MAB6131-SP
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GFR alpha-2/GDNF R alpha-2 Antibody (71515) [CoraFluor™ 1] Summary

Description
CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
Immunogen
Mouse myeloma cell line NS0-derived recombinant human GFR alpha ‑2/GDNF R alpha ‑2
Ser22-Ser441
Accession # O00451
Specificity
Detects human GFR alpha ‑2/GDNF R alpha ‑2 in direct ELISAs.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Purity
Protein A or G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunocytochemistry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark. Do not freeze.
Buffer
PBS
Preservative
No Preservative
Purity
Protein A or G purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for GFR alpha-2/GDNF R alpha-2 Antibody (71515) [CoraFluor™ 1]

  • GDNF family receptor alpha 2
  • GDNF family receptor alpha-2
  • GDNF R alpha-2
  • GDNF receptor alpha-2
  • GDNF receptor beta
  • GDNFR-alpha-2
  • GDNFR-beta
  • GDNFRBRET ligand 2
  • GFR alpha2
  • GFR alpha-2
  • GFRA2
  • GFRa-2
  • GFR-alpha 2
  • GFR-alpha-2
  • glial cell line derived neurotrophic factor receptor, beta
  • Neurturin receptor alpha
  • NRTNR-alpha
  • NTNRA
  • NTNR-alpha
  • PI-linked cell-surface accessory protein
  • RETL2TGF-beta-related neurotrophic factor receptor 2
  • TGF-beta related neurotrophic factor receptor 2
  • TRN receptor, GPI-anchored
  • TRNR2NRTNR-ALPHA

Background

Members of the glial cell line derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuron survival and differentiation. Physiological responses to NTN require the presence of a novel glycosylphosphadidylinositol linked protein NTNRa, which is a cell surface receptor for NTN. The cDNAs encoding NTNRa from human, rat, chicken, and mouse have been cloned recently. NTNRa was also termed GDNFRb, Ret ligand 2 (RETL2) or TGFb related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRa2 recently. GFRa2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRa2, and the Ret PTK form a complex to transduce NTN signal and to mediate NTN function.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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