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FoxP3 Antibody (1054C) [Biotin]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications Flow, IHC, Dual ISH-IHC, ICC/IF
Clone
1054C
Clonality
Monoclonal
Host
Rabbit
Conjugate
Biotin

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
IC8214U-100UG
Alexa Fluor 405
IC8214V-100UG
Alexa Fluor 488
IC8214G-100
Alexa Fluor 532
FAB8214X
Alexa Fluor 594
IC8214T-100UG
Alexa Fluor 647
IC8214R-100UG
Alexa Fluor 700
IC8214N-100
Alexa Fluor 750
IC8214S-100UG
Allophycocyanin
IC8214A-100
Allophycocyanin
FPK8214A-100
Allophycocyanin
FPK8214A-025
Allophycocyanin/Cy7
FAB8214APCCY7
CoraFluor 1
FAB8214CL1
DyLight 350
FAB8214D
DyLight 405
FAB8214E
DyLight 488
FAB8214K
DyLight 550
FAB8214L
DyLight 594
FAB8214M
DyLight 650
FAB8214W
DyLight 680
FAB8214Y
DyLight 755
FAB8214Z
FITC
FAB8214F
HRP
FAB8214H
Janelia Fluor 525
FAB8214JF525
Janelia Fluor 549
FAB8214I
Janelia Fluor 585
FAB8214JF585
Janelia Fluor 635
FAB8214JF635
Janelia Fluor 646
FAB8214J
Janelia Fluor 669
FAB8214JF669
PE/Atto594
FAB8214PEATT594
PE/Cy5.5
FAB8214PECY55
PE/Cy7
FAB8214PECY7
PerCP
FAB8214C
Phycoerythrin
FPK8214P-100
Phycoerythrin
FPK8214P-025
Phycoerythrin
IC8214P-100
Unconjugated
MAB8214
mFluor Violet 450 SE
FAB8214MFV450
mFluor Violet 500 SE
FAB8214MFV500
mFluor Violet 610 SE
FAB8214MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB8214
Carrier Free
IC8214P-100
Carrier Free
IC8214A-100
Carrier Free
IC8214G-100
Carrier Free
IC8214N-100
Carrier Free
FPK8214A-025
Carrier Free
FPK8214A-100
Carrier Free
FPK8214P-025
Carrier Free
FPK8214P-100
Carrier Free
MAB8214
Carrier Free
MAB8214-SP
Carrier Free
IC8214V-100UG
Carrier Free
IC8214U-100UG
Carrier Free
IC8214T-100UG
Carrier Free
IC8214S-100UG
Carrier Free
IC8214R-100UG
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FoxP3 Antibody (1054C) [Biotin] Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
E. coli-derived recombinant human FoxP3
Met1-Leu71
Accession # Q9BZS1
Specificity
Detects human FoxP3 in direct ELISAs. Detects human and mouse FoxP3 in flow cytometry.
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
FOXP3
Purity
Protein A or G purified from cell culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Dual RNAscope ISH-IHC
  • Flow Cytometry
  • Immunocytochemistry
  • Immunohistochemistry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from cell culture supernatant

Alternate Names for FoxP3 Antibody (1054C) [Biotin]

  • AIID
  • AIIDMGC141961
  • DIETER
  • forkhead box P3
  • Forkhead Box Protein P3
  • FoxP3
  • FOXP3delta7
  • immune dysregulation, polyendocrinopathy, enteropathy, X-linked
  • Immunodeficiency, Polyendocrinopathy, Enteropathy, X-Linked
  • IPEX
  • JM2
  • MGC141961
  • MGC141963
  • PIDX
  • PIDXMGC141963
  • SCURFIN
  • XPID
  • XPIDpolyendocrinopathy, enteropathy, X-linked

Background

Forkhead box P3 (FoxP3), aka Scurfin and JM2, is a protein involving in immune system responses and functioning as a transcriptional regulator crucial in the development and inhibitory of regulatory T-Cells (Treg). FoxP3 is a master regulator of the Treg lineage, who requires Ahr and STAT-5 and other additional transcription factors to retains its complete function and differentiation. Scurfin remains steady and constitutively expressed in two conditions: a high level in CD25 + CD4 positive regulatory T cells and a low level in CD4 positive/CD25 negative cells. JM2 is absent in CD4 negative/CD8 positive T cells. FoxP3 defects are related to various cancers and autoimmune diseases, and X-linked syndrome (IPEX), while overexpression may also cause severe immunodeficiency.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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FAQs for FoxP3 Antibody (FAB8214B). (Showing 1 - 2 of 2 FAQ).

  1. Does FoxP3 antibodies comes in lyophilized form?
    • FoxP3 antibodies, aka JM2 IPEX, and Scurfin antibodies, have the following products in lyophilized form: NBP1-18319, AF3240.
  2. What the theoretical molecular weight for FoxP3 antibodies?
    • The TMW of FoxP3 antibodies is approximately 47 - 52 kDa.

Secondary Antibodies

 

Isotype Controls

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Research Areas for FoxP3 Antibody (FAB8214B)

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Blogs on FoxP3.

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Meeting Report: 2nd International Antibody Validation Meeting
Bio-Techne brands Novus Biologicals® and R&D Systems® were proud to support the 2nd International Antibody Validation Meeting held at Bath University, on the 15-16 September, 2016. Almost 100 participants from around the world, including funde...  Read full blog post.
FOXP3
Is has been established that the regulatory transcription factor FOXP3 (a member of the forkhead/winged-helix family of transcription factors) is imperative to immune system homeostasis through CD4+CD25+ regulatory T cell function.  Distinctively, ...  Read full blog post.
FOXP3 is a Master Regulator of T Regulatory (Treg) Cells
FOXP3, a member of forkhead/winged-helix family of transcription factors acts as a "master" regulator for the development and suppressive function of regulatory T cells (Tregs). Its constitutive expression is necessary for the suppressive function of ...  Read full blog post.
FOXP3: Master Regulatory Transcriptional Factor
FOXP3, a forkhead family transcription factor specially expressed in regulatory T (Treg) cells, controls the expression of many key immune-regulatory genes. Treg cells are a population of T lymphocytes that have critical roles in the immune system hom...  Read full blog post.
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Bioinformatics

Gene Symbol FOXP3