FoxP2 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

FoxP2 (Forkhead box protein P2; also CAGH44) is an 85‑95 kDa member of the winged helix transcription factor gene family. It is a transcriptional repressor that is expressed principally in gut and lung epithelium, and in neurons involved in speech and language. Human FoxP2 is 715 amino acids (aa) in length. It contains a huge poly-Gln region (aa 123‑231), a C2H2 Zn-finger domain (aa 346‑371), a Leu-zipper segment (aa 388‑409) and a forkhead DNA binding domain (aa 504‑594). FoxP2 both homodimerizes and heterodimerizes with FoxP1 and P4, and binds CTBP1. There are multiple splice variants. There is an alternate start site at Met93, an 11 aa substitution for aa 57‑715, a 25 aa insert after Gln86, an 11 aa substitution for aa 133‑715, and a ten aa substitution for aa 423‑715. Over aa 587‑715, human and mouse FoxP2 are (100%) identical in aa sequence.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Mouse, Rat, Western Blot.

We have publications tested in 4 applications: ICC, IHC, Immunohistochemistry, Western Blot.

Showing Publications 1 - 10 of 32. Show All 32 Publications. Collapse Publications.

Publications using AF5647	Applications	Species
Matsuda, T;Kobayashi, K;Kobayashi, K;Noda, M; Two parabrachial Cck neurons involved in the feedback control of thirst or salt appetite Cell reports 2023-12-28 [PMID: 38157299] (Immunohistochemistry, Mouse)	Immunohistochemistry	Mouse
Richie Zhang, Dake Huang, Silvia Gasparini, Joel C. Geerling Efferent projections of Nps -expressing neurons in the parabrachial region bioRxiv 2023-08-19 [PMID: 37645772]
Wang J, Rattner A, Nathans J Bacterial meningitis in the early postnatal mouse studied at single-cell resolution eLife 6/15/2023 [PMID: 37318981]
Jordan T Bateman, Erica S Levitt Opioid suppression of an excitatory pontomedullary respiratory circuit by convergent mechanisms eLife 2023-06-14 [PMID: 37314062]
Kaur, S;Nicole, L;Sela, Y;Lima, J;Thomas, R;Bandaru, S;Saper, C; Lateral parabrachial FoxP2 neurons regulate respiratory responses to hypercapnia Research square 2023-05-05 [PMID: 37205337] (IHC, Mouse)	IHC	Mouse
KD Hwang, J Baek, HH Ryu, J Lee, HG Shim, SY Kim, SJ Kim, YS Lee Cerebellar nuclei neurons projecting to the lateral parabrachial nucleus modulate classical fear conditioning Cell Reports, 2023-03-22;42(4):112291. 2023-03-22 [PMID: 36952344] (IHC, Mouse)	IHC	Mouse
Dake Huang, Richie Zhang, Silvia Gasparini, Miriam C. McDonough, William J. Paradee, Joel C. Geerling Neuropeptide S (NPS) neurons: Parabrachial identity and novel distributions Journal of Comparative Neurology 2022-12-01 [PMID: 36036349]
Ricardo J. Samms, Richard Cosgrove, Brandy M. Snider, Ellen C. Furber, Brian A. Droz, Daniel A. Briere et al. GIPR Agonism Inhibits PYY-Induced Nausea-Like Behavior Diabetes 2022-07-01 [PMID: 35499381]
Samyukta Karthik, Dake Huang, Yaritza Delgado, Justin J. Laing, Lila Peltekian, Gabrielle N. Iverson et al. Molecular ontology of the parabrachial nucleus Journal of Comparative Neurology 2022-07-01 [PMID: 35134251]
D'Souza SP, Swygart DI, Wienbar SR Et al. Retinal patterns and the cellular repertoire of neuropsin (Opn5) retinal ganglion cells The Journal of comparative neurology 11/7/2021 [PMID: 34743323]
Ayla Aksoy-Aksel, Andrea Gall, Anna Seewald, Francesco Ferraguti, Ingrid Ehrlich Midbrain dopaminergic inputs gate amygdala intercalated cell clusters by distinct and cooperative mechanisms in male mice eLife 2021-05-24 [PMID: 34028352]
Dake Huang, Fillan S. Grady, Lila Peltekian, Justin J. Laing, Joel C. Geerling Efferent projections of CGRP/Calca‐expressing parabrachial neurons in mice Journal of Comparative Neurology 2021-08-01 [PMID: 33715169]
RB Roome, FB Bourojeni, B Mona, S Rastegar-P, R Blain, A Dumouchel, C Salesse, WS Thompson, M Brookbank, Y Gitton, L Tessarollo, M Goulding, JE Johnson, M Kmita, A Chédotal, A Kania Phox2a Defines a Developmental Origin of the Anterolateral System in Mice and Humans Cell Rep, 2020-11-24;33(8):108425. 2020-11-24 [PMID: 33238113] (IHC, Rat)	IHC	Rat
AH Pool, T Wang, DA Stafford, RK Chance, S Lee, J Ngai, Y Oka The cellular basis of distinct thirst modalities Nature, 2020-10-14;0(0):. 2020-10-14 [PMID: 33057193] (IHC, Mouse)	IHC	Mouse
Dake Huang, Fillan S. Grady, Lila Peltekian, Joel C. Geerling Efferent projections of Vglut2 , Foxp2 , and Pdyn parabrachial neurons in mice Journal of Comparative Neurology 2021-03-01 [PMID: 32621762]
Lindsay J. Agostinelli, Madison R. Mix, Marco M. Hefti, Thomas E. Scammell, Alexander G. Bassuk Input–output connections of LJA5 prodynorphin neurons Journal of Comparative Neurology 2021-02-01 [PMID: 32602558]
Erica Rodriguez, David Ryu, Shengli Zhao, Bao-Xia Han, Fan Wang Identifying Parabrachial Neurons Selectively Regulating Satiety for Highly Palatable Food in Mice eNeuro 2019-10-24 [PMID: 31662323]
S Lee, V Augustine, Y Zhao, H Ebisu, B Ho, D Kong, Y Oka Chemosensory modulation of neural circuits for sodium appetite Nature, 2019-03-27;568(7750):93-97. 2019-03-27 [PMID: 30918407] (IHC, Mouse)	IHC	Mouse
Silvia Gasparini, Jon M. Resch, Sowmya V. Narayan, Lila Peltekian, Gabrielle N. Iverson, Samyukta Karthik et al. Aldosterone-sensitive HSD2 neurons in mice Brain Structure and Function 2019-01-01 [PMID: 30343334]
Samantha M. Fortin, Mitchell F. Roitman Challenges to Body Fluid Homeostasis Differentially Recruit Phasic Dopamine Signaling in a Taste-Selective Manner The Journal of Neuroscience 2018-08-01 [PMID: 29934352]
CF Yang, JL Feldman Efferent projections of excitatory and inhibitory preB�tzinger complex neurons J. Comp. Neurol., 2018-03-09;0(0):. 2018-03-09 [PMID: 29473167] (IHC, Mouse)	IHC	Mouse
D Stani?, RR Dhingra, M Dutschmann Expression of the transcription factor FOXP2 in brainstem respiratory circuits of adult rat is restricted to upper-airway pre-motor areas Respir Physiol Neurobiol, 2018-02-04;250(0):14-18. 2018-02-04 [PMID: 29414420] (IHC, Western Blot, Rat, Western Blot)	IHC, Western Blot	Rat, Western Blot
E Rodriguez, K Sakurai, J Xu, Y Chen, K Toda, S Zhao, BX Han, D Ryu, H Yin, W Liedtke, F Wang A craniofacial-specific monosynaptic circuit enables heightened affective pain Nat. Neurosci., 2017-11-13;20(12):1734-1743. 11/13/2017 [PMID: 29184209]
AM Verstegen, V Vanderhors, PA Gray, ML Zeidel, JC Geerling Barrington's nucleus: Neuroanatomic landscape of the mouse pontine micturition center J. Comp. Neurol, 2017-04-18;0(0):. 2017-04-18 [PMID: 28340519] (IHC, Mouse)	IHC	Mouse
Joel Geerling K�lliker-Fuse GABAergic and glutamatergic neurons project to distinct targets J. Comp. Neurol, 2017-03-14;0(0):. 2017-03-14 [PMID: 28032634] (ICC, Rat)	ICC	Rat
HSD2 neurons in the hindbrain drive sodium appetite Nat. Neurosci, 2016-12-05;0(0):. 2016-12-05 [PMID: 27918529] (IHC, Mouse)	IHC	Mouse
Rebecca L. Miller, George O. Denny, Mark M. Knuepfer, Thomas R. Kleyman, Edwin K. Jackson, Lawrence B. Salkoff et al. Blockade of ENaCs by amiloride induces c-Fos activation of the area postrema Brain Research 2015-03-19 [PMID: 25557402]
Rebecca L. Miller, Mark M. Knuepfer, Michelle H. Wang, George O. Denny, Paul A. Gray, Arthur D. Loewy Fos-activation of FoxP2 and Lmx1b neurons in the parabrachial nucleus evoked by hypotension and hypertension in conscious rats Neuroscience 2012-08-30 [PMID: 22641087]
Rebecca L. Miller, Matthew K. Stein, Arthur D. Loewy Serotonergic Inputs to the FoxP2 neurons of the Pre-Locus Coeruleus and Parabrachial Nuclei That Project to the Ventral Tegmental Area Neuroscience 2011-10-13 [PMID: 21784133]
Jung-Won Shin, Joel C. Geerling, Matthew K. Stein, Rebecca L. Miller, Arthur D. Loewy FoxP2 brainstem neurons project to sodium appetite regulatory sites Journal of Chemical Neuroanatomy 2011-09-01 [PMID: 21605659]
Joel C. Geerling, Matthew K. Stein, Rebecca L. Miller, Jung-Won Shin, Paul A. Gray, Arthur D. Loewy FoxP2 expression defines dorsolateral pontine neurons activated by sodium deprivation* Brain Research 2011-02-23 [PMID: 21108936]
Matthew K. Stein, Arthur D. Loewy Area postrema projects to FoxP2 neurons of the pre-locus coeruleus and parabrachial nuclei: Brainstem sites implicated in sodium appetite regulation Brain Research 2010-11-04 [PMID: 20816675]
Show All 32 Publications. Collapse Publications.

Array AF5647

• FoxP2 Antibodies
• FoxP2 Lysate
• FoxP2 Proteins