FOX2 Antibody

This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 1 application: WB.

Showing Publications 1 - 9 of 9.

Publications using NB110-40588	Applications	Species
Charlene Priscilla Poore, Jialei Yang, Shunhui Wei, Chee Kong Fhu, Zoë Bichler, Juejin Wang, Tuck Wah Soong, Ping Liao Enhanced isradipine sensitivity in vascular smooth muscle cells due to hypoxia-induced Ca v 1.2 splicing and RbFox1/Fox2 downregulation. The FEBS journal 2024-05-24 [PMID: 38794806]
Li P, Qin D, Chen T et al. Dysregulated Rbfox2 produces aberrant splicing of CaV1.2 calcium channel in diabetes-induced cardiac hypertrophy Cardiovascular diabetology 2023-07-06 [PMID: 37415128] (WB, Rat)	WB	Rat
Welzel F, Kaehler C, Isau M et al. FOX-2 Dependent Splicing of Ataxin-2 Transcript Is Affected by Ataxin-1 Overexpression. PLoS One. 2012-05-30 [PMID: 22666429]
Dittmar KA, Jiang P, Park JW et al. Genome-wide determination of a broad ESRP-regulated posttranscriptional network by high-throughput sequencing. Mol Cell Biol 2012-04-01 [PMID: 22354987]
Chang LK, Chuang JY, Nakao M et al. MCAF1 and synergistic activation of the transcription of Epstein-Barr virus lytic genes by Rta and Zta. Nucleic Acids Res 2010-08-01 [PMID: 20385599]
Damianov A, Black DL. Autoregulation of Fox protein expression to produce dominant negative splicing factors. RNA 2010-02-01 [PMID: 20042473]
Tang ZZ, Zheng S, Nikolic J et al. Developmental control of CaV1.2 L-type calcium channel splicing by Fox proteins. Mol Cell Biol 2009-09-01 [PMID: 19564422]
Yeo GW, Coufal NG, Liang TY et al. An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells. Nat Struct Mol Biol 2009-02-01 [PMID: 19136955]
Zhang C, Zhang Z, Castle J et al. Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2. Genes Dev 2008-09-01 [PMID: 18794351]

Array NB110-40588

• FOX2 Antibodies
• FOX2 Lysates
• FOX2 Protein