Fibroblast Activation Protein alpha/FAP Antibody (983802) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

FAP (also known as seprase) is a 95 kDa Type II transmembrane serine protease that is structurally related to dipeptidyl peptidase IV (DPPIV/CD26) (1, 2). Within the extracellular domain, mouse FAP shares 90% and 97% amino acid (aa) sequence identity with human and rat FAP, respectively (3, 4). Alternative splicing of mouse FAP generates isoforms with a 33 aa or 5 aa deletion in the extracellular juxtamembrane region (3). FAP is expressed on reactive stromal fibroblasts in tumor tissue and wound healing and on synoviocytes in rheumatoid arthritis (1, 5-7). It exhibits dipeptidyl peptidase activity with substrate specificity similar to DPPIV, which is specific for N-terminal Xaa-Pro sequences (5, 8). FAP is also an endopeptidase that can degrade Gelatin, Collagens I and IV, Fibronectin, and Laminin (1, 5, 8) as well as several peptide hormones (e.g. Neuropeptide Y, Brain Natriuretic Peptide, Substance P, Peptide YY, and Incretins) (9). The enzymatic activity is dependent on FAP association with DPPIV on the cell surface (5, 8, 10, 11). The matrix-dedgrading activity of FAP contributes to tumor cell migration and invasion (10-13). In addition, FAP can enhance tumor cell growth by limiting the development of anti-tumor immunity (14).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Transgenic Mouse.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 5 of 5.

Publications using MAB9727	Applications	Species
Downton, P;Dickson, SH;Ray, DW;Bechtold, DA;Gibbs, JE; Fibroblast-like synoviocytes orchestrate daily rhythmic inflammation in arthritis Open biology 2024-07-01 [PMID: 38981514] (Flow Cytometry, Transgenic Mouse)	Flow Cytometry	Transgenic Mouse
Glabman, RA;Olkowski, CP;Minor, HA;Bassel, LL;Kedei, N;Choyke, PL;Sato, N; Tumor Suppression by Anti-Fibroblast Activation Protein Near-Infrared Photoimmunotherapy Targeting Cancer-Associated Fibroblasts Cancers 2024-01-20 [PMID: 38275890] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Shipra Das, Julien Valton, Philippe Duchateau, Laurent Poirot Stromal depletion by TALEN-edited universal hypoimmunogenic FAP-CAR T cells enables infiltration and anti-tumor cytotoxicity of tumor antigen-targeted CAR-T immunotherapy Frontiers in Immunology 5/12/2023 [PMID: 37251405]
J Liu, Y Wang, C Mu, M Li, K Li, S Li, W Wu, L Du, X Zhang, C Li, W Peng, J Shen, Y Liu, D Yang, K Zhang, Q Ning, X Fu, Y Zeng, Y Ni, Z Zhou, Y Liu, Y Hu, X Zheng, T Wen, Z Li, Y Liu Pancreatic tumor eradication via selective Pin1 inhibition in cancer-associated fibroblasts and T lymphocytes engagement Nature Communications, 2022-07-25;13(1):4308. 2022-07-25 [PMID: 35879297] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
C Wormsbaech, AR Hindman, A Avendano, M Cortes-Med, CE Jones, A Bushman, L Onua, CE Kovalchin, AR Murphy, HL Helber, A Shapiro, K Voytovitch, X Kuang, R Aguilar-Va, JL Leight, JW Song, CJ Burd In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness Breast Cancer Res., 2020-05-05;22(1):41. 2020-05-05 [PMID: 32370801] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse

Array MAB9727

• Fibroblast Activation Protein alpha/FAP Antibodies
• Fibroblast Activation Protein alpha/FAP Lysate
• Fibroblast Activation Protein alpha/FAP ELISAs
• Fibroblast Activation Protein alpha/FAP Proteins and Enzymes