DRAK1 Antibody (684324) Summary
Immunogen |
E. coli-derived recombinant human DRAK1 Ala115-Glu313 Accession # Q9UEE5 |
Specificity |
Detects human DRAK1 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) DRAK2, rhDAPK1, rhDAPK2, or rhDAPK3 is observed. In Western blots, no cross-reactivity with rhDRAK2 is observed. |
Source |
N/A |
Isotype |
IgG1 |
Clonality |
Monoclonal |
Host |
Mouse |
Gene |
STK17A |
Purity Statement |
Protein A or G purified from hybridoma culture supernatant |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Packaging, Storage & Formulations
Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. - 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
|
Buffer |
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
Preservative |
No Preservative |
Concentration |
LYOPH |
Reconstitution Instructions |
Sterile PBS to a final concentration of 0.5 mg/mL. |
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for DRAK1 Antibody (684324)
Background
DRAK1 (DAP kinase-related apoptosis-inducing protein kinase 1; also STK17A) is a 55 kDa member of the DAP kinase subfamily, CAMK Ser/Thr protein kinase family of enzymes. It is expressed in osteoclasts, resides in the nucleus, and initiates apoptosis. Human DRAK1 is 414 amino acids (aa) in length. It contains an N-terminal polyPro segment (aa 33-37) followed by a Ser/Thr kinase domain (aa 64-321) with a catalytic loop (aa 184-193). Apoptosis apparently requires an intact kinase domain. No rodent DRAK1 has been reported. Over aa 115-313, human DRAK1 shares 95% aa identity with canine DRAK1, and 65% aa identity with human DRAK2.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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