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DRAK1 Antibody (684324)

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Western blot shows lysates of MOLT-4 human acute lymphoblastic leukemia cell line and A431 human epithelial carcinoma cell line. PVDF Membrane was probed with 1 µg/mL of Mouse Anti-Human DRAK1 Monoclonal Antibody ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clone
684324
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

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DRAK1 Antibody (684324) Summary

Immunogen
E. coli-derived recombinant human DRAK1
Ala115-Glu313
Accession # Q9UEE5
Specificity
Detects human DRAK1 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) DRAK2, rhDAPK1, rhDAPK2, or rhDAPK3 is observed. In Western blots, no cross-reactivity with rhDRAK2 is observed.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
STK17A
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Sterile PBS to a final concentration of 0.5 mg/mL.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for DRAK1 Antibody (684324)

  • DAP kinase-related apoptosis-inducing protein kinase 1
  • DRAK1
  • DRAK1death-associated protein kinase-related 1
  • EC 2.7.11.1
  • serine/threonine kinase 17a (apoptosis-inducing)
  • serine/threonine kinase 17a
  • serine/threonine-protein kinase 17A
  • STK17A

Background

DRAK1 (DAP kinase-related apoptosis-inducing protein kinase 1; also STK17A) is a 55 kDa member of the DAP kinase subfamily, CAMK Ser/Thr protein kinase family of enzymes. It is expressed in osteoclasts, resides in the nucleus, and initiates apoptosis. Human DRAK1 is 414 amino acids (aa) in length. It contains an N-terminal polyPro segment (aa 33-37) followed by a Ser/Thr kinase domain (aa 64-321) with a catalytic loop (aa 184-193). Apoptosis apparently requires an intact kinase domain. No rodent DRAK1 has been reported. Over aa 115-313, human DRAK1 shares 95% aa identity with canine DRAK1, and 65% aa identity with human DRAK2.      

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol STK17A
Uniprot