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Desmocollin-1 Antibody

Images

 
Immunohistochemistry-Paraffin: Desmocollin-1 Antibody [NBP2-62695] - Staining of human Placenta shows no positivity in trophoblastic cells as expected.
Orthogonal Strategies: Immunohistochemistry-Paraffin: Desmocollin-1 Antibody [NBP2-62695] - Analysis in human skin and pancreas tissues using Anti-DSC1 antibody. Corresponding DSC1 RNA-seq data are presented for ...read more
Immunohistochemistry-Paraffin: Desmocollin-1 Antibody [NBP2-62695] - Staining of human skin shows high expression.
Immunohistochemistry-Paraffin: Desmocollin-1 Antibody [NBP2-62695] - Staining of human hair shows strong membranous and cytoplasmic positivity in internal root sheath.
Immunohistochemistry-Paraffin: Desmocollin-1 Antibody [NBP2-62695] - Staining of human pancreas shows low expression as expected.
Immunohistochemistry-Paraffin: Desmocollin-1 Antibody [NBP2-62695] - Analysis in human skin and pancreas tissues using NBP2-62695 antibody. Corresponding DSC1 RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: Desmocollin-1 Antibody [NBP2-62695] - Staining of human Endometrium shows no positivity in glandular cells as expected.
Immunohistochemistry-Paraffin: Desmocollin-1 Antibody [NBP2-62695] - Staining of human Pancreas shows no positivity in exocrine glandular cells as expected.
Immunohistochemistry-Paraffin: Desmocollin-1 Antibody [NBP2-62695] - Staining of human Skin shows strong membranous positivity in squamous epithelial cells.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Validated by:
       

Orthogonal Strategies

 

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Desmocollin-1 Antibody Summary

Immunogen
This antibody was developed against a recombinant protein corresponding to amino acids: RQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPAGQELLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHTG
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
DSC1
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
Desmocollin-1 Recombinant Protein Antigen (NBP2-62695PEP)

Reactivity Notes

Mouse (80%)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Protein A purified

Alternate Names for Desmocollin-1 Antibody

  • cadherin family member 1
  • CDHF1
  • desmocollin 1
  • Desmocollin1
  • Desmocollin-1
  • desmosomal glycoprotein 2/3
  • DG2/DG3
  • DG2/DG3
  • DSC1

Background

The protein encoded by the Desmosomal Protein gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol DSC1