Corneodesmosin Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Corneodesmosin, also known as CDSN and the S gene product, is a highly polymorphic secreted glycoprotein that plays an important structural role in the skin (1). It is expressed by differentiated keratinocytes in the corneal layer of the skin and is a major component of corneodesmosomes (2-4). It is also expressed in the inner root sheath of hair follicles (5, 6). Corneodesmosome has a high content of glycine, serine, and proline residues that promote its folding into a series of Gly-loop domains (2, 7). Corneodesmosin forms oligomers and associates homophilically to strengthen the adhesion between corneocytes (8, 9). Corneodesmosin-deficient mice exhibit a detachment of the corneal layer of the skin as well as hypotrichosis of the scalp and baldness (6, 10). Corneodesmosin is secreted by keratinocytes as a 52-56 kDa molecule which is then subjected to repeated sequential N- and C-terminal proteolysis (11). Species of 46, 43, 36, and 15 kDa are present in corneocytes (7, 11). Cleavage of the N-terminal Gly-loop diminishes Corneodesmosin’s ability to mediate adhesion, and this is a prerequisite for normal desquamation of the skin (8, 9). Reduced proteolysis of Corneodesmosin in psoriasis lesions is associated with the persistence of corneodesmosomes and scale retention (12). Premature truncation of Corneodesmosin is associated with hypotrichosis of the scalp (13).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IHC, IHC-P.

Showing Publications 1 - 3 of 3.

Publications using AF5725	Applications	Species
H Qin, J Jin, H Fischer, M Mildner, M Gschwandtn, V Mlitz, L Eckhart, E Tschachler The caspase-1 inhibitor CARD18 is specifically expressed during late differentiation of keratinocytes and its expression is lost in lichen planus J. Dermatol. Sci., 2017-05-01;0(0):. 2017-05-01 [PMID: 28506683] (IHC, Human)	IHC	Human
E Jacquin, S Leclerc-Me, C Judon, E Blanchard, S Fraitag, O Florey Pharmacological modulators of autophagy activate a parallel noncanonical pathway driving unconventional LC3 lipidation Autophagy, 2017-02-15;0(0):1-14. 2017-02-15 [PMID: 28296541] (IHC, Human)	IHC	Human
Kim SH, Kim S Callus formation is associated with hyperproliferation and incomplete differentiation of keratinocytes, and increased expression of adhesion molecules. Br. J. Dermatol., 2010-04-30;0(0):. 2010-04-30 [PMID: 20456341] (IHC-P, Human)	IHC-P	Human

Array AF5725

• Corneodesmosin Antibodies
• Corneodesmosin ELISA Kit
• Corneodesmosin Lysate
• Corneodesmosin Proteins
• Corneodesmosin Proteins and Enzymes