DC-SIGN+DC-SIGNR Antibody (120612)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

DC-SIGN (Dendritic Cell- Specific ICAM-3 Grabbing Non-Integrin) has been shown to play an important role in regulating dendritic cell (DC) and T cell interactions, including antigen presentation to T cells and enhancement of transinfection of CD4+ T cells by HIV-1 (1, 2). Efforts to identify additional type II membrane proteins resulted in the isolation of a molecule related in sequence to DC-SIGN known as DC-SIGNR (DC-SIGN Related) (3, 4). DC-SIGNR shares 73 - 80% amino acid homology with DC-SIGN and is located on human chromosome 19p13.3. Its structure is similar to DC-SIGN and therefore binds mannose residues in a calcium dependent fashion, including ICAM-3 and HIV-1 gp120 (5). DC-SIGNR, also known as L-SIGN (Liver/Lymph node-Specific ICAM-3-Grabbing Non-integrin) and DC-SIGNR, is polymorphic since allelic variations of the exon 4 encoded sequence have been isolated (5). This is further supported by a study demonstrating the ability to isolate a large repertoire of DC-SIGNR transcripts largely the result of alternative splicing of the 7 coding exons (6). L-SIGN/DC-SIGNR is primarily transcribed in the liver and lymph nodes but not in monocyte derived DC (5). Expression of L-SIGN/DC-SIGNR is restricted to endothelial cells derived from liver sinusoids, lymph nodes sinuses and capillaries (7) although variable expression in placenta and some monocytic cell lines has also been reported, including both membrane and soluble isoforms of the protein (6). Expression of DC-SIGN is induced during the in-vitro generation of DC from either monocytes or bone marrow progenitors, with maximal surface expression at day 7 of culture (1). Immature DC in the skin and mature DC in the tonsil have been demonstrated to express DC-SIGN (8). Analysis of various tissues and cell lines suggests that DC-SIGN expression is restricted to DC (1) although a more recent report finds evidence of expression in placenta, resting monocytes and monocytic cell lines (6). This discrepancy may be partially related to the multiple isoforms of DC-SIGN transcripts, including both membrane and soluble forms, as well as exon splice variants reported in the latter study (6).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Primate - Macaca mulatta (Rhesus Macaque).

We have publications tested in 6 applications: Flow Cytometry, Functional Assay, ICC, IHC, IHC-P, Neutralization.

Showing Publications 1 - 10 of 17. Show All 17 Publications. Collapse Publications.

Publications using MAB1621	Applications	Species
Messingham, KN;Richards, PT;Fleck, A;Patel, RA;Djurkovic, M;Elliff, J;Connell, S;Crowe, TP;Munoz Gonzalez, J;Gourronc, F;Dillard, JA;Davey, RA;Klingelhutz, A;Shtanko, O;Maury, W; Multiple cell types support productive infection and dynamic translocation of infectious Ebola virus to the surface of human skin Science advances 2025-01-03 [PMID: 39742475] (Flow Cytometry, Human)	Flow Cytometry	Human
Rader, AG;Cloherty, APM;Patel, KS;Almandawi, DDA;Pajkrt, D;Wolthers, KC;Sridhar, A;van Piggelen, S;Baaij, LE;Schreurs, RRCE;Ribeiro, CMS; HIV-1 exploits LBPA-dependent intraepithelial trafficking for productive infection of human intestinal mucosa PLoS pathogens 2024-12-01 [PMID: 39729509] (Flow Cytometry, Human)	Flow Cytometry	Human
Diop, MK;Molina, OE;Birlea, M;LaRue, H;Hovington, H;T�tu, B;Lacombe, L;Bergeron, A;Fradet, Y;Trudel, D; Leukocytic Infiltration of Intraductal Carcinoma of the Prostate: An Exploratory Study Cancers 2023-04-09 [PMID: 37190147] (IHC, Human)	IHC	Human
Monika Horvat Mercnik, Carolin Schliefsteiner, Herbert Fluhr, Christian Wadsack Placental macrophages present distinct polarization pattern and effector functions depending on clinical onset of preeclampsia Frontiers in Immunology 2023-01-12 [PMID: 36713449]
M Puray-Chav, KM LaPak, TP Schrank, JL Elliott, DP Bhatt, MJ Agajanian, R Jasuja, DQ Lawson, K Davis, PW Rothlauf, Z Liu, H Jo, N Lee, K Tenneti, JE Eschbach, C Shema Mugi, EM Cousins, EW Cloer, HR Vuong, LA VanBlargan, AL Bailey, P Gilchuk, JE Crowe, MS Diamond, DN Hayes, SPJ Whelan, A Horani, SL Brody, D Goldfarb, MB Major, SB Kutluay Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell Cell Reports, 2021-06-23;0(0):109364. 2021-06-23 [PMID: 34214467] (Functional Assay, Human)	Functional Assay	Human
Morcom L, Gobius I, Marsh AP et al. DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation eLife 4/19/2021 [PMID: 33871356]
Caroline Dunk, Melissa Kwan, Aleah Hazan, Sierra Walker, Julie K. Wright, Lynda K. Harris et al. Failure of Decidualization and Maternal Immune Tolerance Underlies Uterovascular Resistance in Intra Uterine Growth Restriction Front Endocrinol (Lausanne) 2019-03-20 [PMID: 30949130]
KM Aagaard, A Lahon, MA Suter, RP Arya, MD Seferovic, MB Vogt, M Hu, F Stossi, MA Mancini, RA Harris, M Kahr, C Eppes, M Rac, MA Belfort, CS Park, D Lacorazza, R Rico-Hesse Primary Human Placental Trophoblasts are Permissive for Zika Virus (ZIKV) Replication Sci Rep, 2017-01-27;7(0):41389. 2017-01-27 [PMID: 28128342] (ICC, Human)	ICC	Human
Uukuniemi virus as a tick-borne virus model J Virol, 2016-07-11;0(0):. 2016-07-11 [PMID: 27194760] (Neutralization, Human)	Neutralization	Human
Hideki Tani, Masayuki Shimojima, Shuetsu Fukushi, Tomoki Yoshikawa, Aiko Fukuma, Satoshi Taniguchi et al. Characterization of Glycoprotein-Mediated Entry of Severe Fever with Thrombocytopenia Syndrome Virus Journal of Virology 2016-06-01 [PMID: 26984731]
Georgios A. Sotiriou, Ann M. Hirt, Pierre-Yves Lozach, Alexandra Teleki, Frank Krumeich, Sotiris E. Pratsinis Hybrid, Silica-Coated, Janus-Like Plasmonic-Magnetic Nanoparticles Chemistry of Materials 2011-04-12 [PMID: 23729990]
Chen Y, Hwang S, Chan V, Chung N, Wang S, Li Z, Ma J, Lin C, Hsieh Y, Chang K, Kung S, Wu Y, Chu C, Tai H, Gao G, Zheng B, Yokoyama K, Austyn J, Lin C Binding of HIV-1 gp120 to DC-SIGN promotes ASK-1-dependent activation-induced apoptosis of human dendritic cells. PLoS Pathog, 2013-01-31;9(1):e1003100. 2013-01-31 [PMID: 23382671] (Neutralization, Human)	Neutralization	Human
Mansfield K, Lang SM, Gauduin MC, Sanford HB, Lifson JD, Johnson RP, Desrosiers RC Vaccine protection by live, attenuated simian immunodeficiency virus in the absence of high-titer antibody responses and high-frequency cellular immune responses measurable in the periphery. J. Virol., 2008-02-13;82(8):4135-48. 2008-02-13 [PMID: 18272584] (ICC, Primate - Macaca mulatta (Rhesus Macaque))	ICC	Primate - Macaca mulatta (Rhesus Macaque)
Deiva K, Khiati A, Hery C, Salim H, Leclerc P, Horellou P, Tardieu M CCR5-, DC-SIGN-dependent endocytosis and delayed reverse transcription after human immunodeficiency virus type 1 infection in human astrocytes. AIDS Res. Hum. Retroviruses, 2006-11-01;22(11):1152-61. 2006-11-01 [PMID: 17147503] (Flow Cytometry, ICC, Neutralization, Human)	Flow Cytometry, ICC, Neutralization	Human
Falkowska E, Durso R, Gardner J, Cormier E, Arrigale R, Ogawa R, Donovan G, Maddon P, Olson W, Dragic T L-SIGN (CD209L) isoforms differently mediate trans-infection of hepatoma cells by hepatitis C virus pseudoparticles. J Gen Virol, 2006-09-01;87(0):2571-6. 2006-09-01 [PMID: 16894195] (Flow Cytometry, Human)	Flow Cytometry	Human
Yearley JH, Pearson C, Carville A, Shannon RP, Mansfield KG SIV-associated myocarditis: viral and cellular correlates of inflammation severity. AIDS Res. Hum. Retroviruses, 2006-06-01;22(6):529-40. 2006-06-01 [PMID: 16796528] (IHC-P, Primate - Macaca mulatta (Rhesus Macaque))	IHC-P	Primate - Macaca mulatta (Rhesus Macaque)
Wu L, 107253, Bashirova AA, Martin TD, Villamide L, Mehlhop E, Chertov AO, Unutmaz D, Pope M, Carrington M, KewalRamani VN Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN. IL-6 signalling biomarkers in hospitalised patients with moderate to severe SARS-CoV-2 infection in a single centre study in Sweden, 2002-01-29;99(3):1568-73. 2002-01-29 [PMID: 11818554] (Flow Cytometry, Human, Primate - Macaca mulatta (Rhesus Macaque))	Flow Cytometry	Human, Primate - Macaca mulatta (Rhesus Macaque)
Show All 17 Publications. Collapse Publications.

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• DC-SIGN+DC-SIGNR Antibodies