Cytohesin-1 Antibody (6G11) Summary
Immunogen |
Purified, His-tagged cytohesin-1. |
Isotype |
IgG1 |
Clonality |
Monoclonal |
Host |
Mouse |
Gene |
CYTH1 |
Purity |
PEG purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Immunocytochemistry/ Immunofluorescence 1:100
- Immunohistochemistry 1:200 - 500
- Immunohistochemistry-Paraffin 1:200 - 500
- Immunoprecipitation 1:10 - 1:500
- Western Blot 1.0 ug/ml
|
Application Notes |
WB: Detects an approx. 48 kDa band representing both cytohesin-1 and cytohesin-2. IP: Only precipitates cytohesin-2. |
Packaging, Storage & Formulations
Storage |
Store at -20C. Avoid freeze-thaw cycles. |
Buffer |
PBS with 1 mg/ml BSA |
Preservative |
0.05% Sodium Azide |
Concentration |
1 mg/ml |
Purity |
PEG purified |
Alternate Names for Cytohesin-1 Antibody (6G11)
Background
Pleckstrin homology, Sec7 and coiled/coil domains 1 (PSCD1) is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The PSCD1 is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. PSCD1 protein is 83% homologous to PSCD2.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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