Cyclin A2 Antibody (E67) [Janelia Fluor® 525]

Full length bovine Cyclin A2 protein (Uniprot: P20248)

aa 144-148

Predominantly nuclear

It recognizes a protein of 54kDa, which is identified as cyclin A. Its epitope is located amino acids 144-148 of human Cyclin A2. Cyclins are regulatory subunits of the cyclin-dependent kinases (cdks. These cyclin/cdk complexes are essential for passage through specific stages in the cell cycle. In mammalian somatic cells, cyclin A is required for S-phase and passage through G2-phase. The D and E type cyclins regulate the passage of G1, while cyclin B is a critical regulator of mitosis. Mutation or disruption of normal cyclin A expression causes cells to arrest in G2-phase.

IgG2a Kappa

Monoclonal

Mouse

CCNA2

Protein A or G purified

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Optimal dilution of this antibody should be experimentally determined.