CXCL8/IL-8 Antibody (6217) [Fluorescein]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CXCL8/IL-8 is an 8-9 kDa member of the CXCL subfamily of chemokines. It was originally discovered and purified independently by a number of laboratories as a neutrophil chemotactic and activating factor. It has also referred to as Neutrophil Activating Protein (NAP), Monocyte-derived Neutrophil Chemotactic Factor (MDNCF) and granulocyte chemotactic protein (GCP). Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes, and mammary plus alveolar epithelium can produce CXCL8 in response to a wide variety of stimuli, such as IL-1b, TNF-a, LPS, MRP-8/14 and viruses. When secreted, it circulates as both a monomer and dimer, with the dimeric forms being a homodimer and heterodimer with CXCL4/PF4. CXCL8 binds to CXCR-1 and -2, with the CXCL8 monomer favoring CXCR-1, and the CXCL8 homodimer favoring CXCR-2 and glycosaminoglycans. CXCL8 is a potent chemoattractant for neutrophils. In addition, CXCL8 also has a wide range of other pro-inflammatory effects. CXCL8 causes degranulation of neutrophil specific granules and azurophilic granules. It also induces expression of the cell adhesion molecules CD11/CD18, and enhances the adherence of neutrophils to endothelial cells and sub-endothelial matrix proteins. Besides neutrophils, CXCL8 is also chemotactic for basophils, T cells and eosinophils. CXCL8 has been reported to be a co-mitogen for keratinocytes, and has also shown to be an autocrine growth factor for melanoma cells. CXCL8 is also reported to be angiogenic both in vivo and in vitro. There is no direct structural rodent counterpart to human IL-8.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Flow Cytometry, ICC.

Showing Publications 1 - 3 of 3.

Publications using IC208F	Applications	Species
Thiel A, Kesselring R, Pries R, Puzik A, Wittkopf N, Wollenberg B Expression of the T cell receptor alpha/beta on a CD123+ BDCA2+ HLA-DR+ subpopulation in head and neck squamous cell carcinoma. PLoS ONE, 2011-01-11;6(1):e15997. 2011-01-11 [PMID: 21264308] (Flow Cytometry, Human)	Flow Cytometry	Human
Eberlein J, Nguyen TT, Victorino F, Golden-Mason L, Rosen HR, Homann D Comprehensive assessment of chemokine expression profiles by flow cytometry. J. Clin. Invest., 2010-02-08;120(3):907-23. 2010-02-08 [PMID: 20197626] (Flow Cytometry, Human)	Flow Cytometry	Human
Mendez-Cruz AR, Paez A, Jimenez-Flores R, Reyes-Reali J, Varela E, Cerbulo-Vazquez A, Rodriguez E, Lopez-Marure R, Masso FA, Flores-Romo L, Montano LF Increased expression of inflammation-related co-stimulatory molecules by HUVECs from newborns with a strong family history of myocardial infarction stimulated with TNF-alpha and oxLDL. Immunol. Lett., 2007-07-23;111(2):116-23. 2007-07-23 [PMID: 17675167] (ICC, Human)	ICC	Human

Array IC208F

• CXCL8/IL-8 Antibodies
• CXCL8/IL-8 Antibody Pair
• CXCL8/IL-8 ELISA Kits
• CXCL8/IL-8 Kits
• CXCL8/IL-8 Lysate
• CXCL8/IL-8 Proteins
• CXCL8/IL-8 Proteins and Enzymes
• CXCL8/IL-8 ELISAs