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CXCL11/I-TAC Antibody [Biotin]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, ELISA(Det)
Clonality
Polyclonal
Host
Goat
Conjugate
Biotin
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Unconjugated
AF572
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
AF572
Carrier Free
AF572
Carrier Free
AF572-SP
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CXCL11/I-TAC Antibody [Biotin] Summary

Immunogen
E. coli-derived recombinant mouse CXCL11/I-TAC
Phe22-Met100
Accession # Q9JHH5
Specificity
Detects mouse CXCL11/I-TAC in ELISAs and Western blots. In sandwich immunoassays, less than 0.2% cross‑reactivity with recombinant human CCL11, recombinant mouse (rm) BLC, rmCRG-2, rmGCP-2, rmMIG, rmPF4, and rmSDF-1 alpha is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
CXCL11
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • ELISA Capture (Matched Antibody Pair) 0.2-0.8 ug/mL
  • ELISA Detection (Matched Antibody Pair) 0.1-0.4 ug/mL
  • ELISA Standard (Matched Pair)
  • Western Blot 0.1 ug/mL
Application Notes
ELISA Capture: Mouse CXCL11/I-TAC Antibody (Catalog # AF572)
ELISA Detection: Mouse CXCL11/I-TAC Biotinylated Antibody (Catalog # BAF572)
Standard: Recombinant Mouse CXCL11/I-TAC (Catalog # 572-MC)
Readout System
Publications
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BAF572 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CXCL11/I-TAC Antibody [Biotin]

  • beta-R1
  • b-R1
  • chemokine (C-X-C motif) ligand 11
  • CXCL11
  • H174
  • H174IP9
  • Interferon gamma-inducible protein 9
  • Interferon-inducible T-cell alpha chemoattractant
  • IP-9member 11
  • ITAC
  • I-TAC
  • I-TACMGC102770
  • SCYB9B
  • small inducible cytokine subfamily B (Cys-X-Cys), member 9B
  • Small-inducible cytokine B11

Background

CXCL11 (also known as I-TAC, SCYB9B, H174, IP-9, and beta -R1) is a member within the non-ELR CXC chemokine subgroup and has been designated CXCL11. CXCL11, together with MIG and IP-10, constitute a subset of chemokines that are ligands for CXCR3, a chemokine receptor that is primarily expressed on activated Th1 cells and NK cells. The three chemokines were also reported to act as antagonists for CCR3, a chemokine receptor that is preferentially expressed on activated Th2 cells. Mouse CXCL11 cDNA encodes a 100 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide that is cleaved to yield a 79 aa residue mature protein. Mature mouse and human CXCL11 share 71% aa sequence identity. Mouse CXCL11 also shares 36% and 29% aa sequence identity with mouse IP-10 (CRG-2) and mouse MIG, respectively. The gene for mouse CXCL11 has been mapped to chromosome 5, in close proximity to the IP-10 and MIG genes. Mouse CXCL11 is induced in multiple tissues during endoxemia, with the greatest expression in lung, heart, small intestine, and kidney. The endotoxemia-induced mouse CXCL11 expression is strongly attenuated by treatment with glucocorticoid.

  1. Widney, D.P. et al. (2000) J. Immunol. 164:6322.
  2. Meyer, M. et al. (2000) Cytogenet. Cell Genet. 88:278.
  3. Loetscher, P. et al. (2001) J. Biol. Chem. Manuscript M005652200.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CXCL11/I-TAC Antibody (BAF572)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: IHC-P.


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Bioinformatics

Gene Symbol CXCL11
Uniprot