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Connexin 30/GJB6 Antibody

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Product Details

Summary
Reactivity Hu, Mu, Rt, BvSpecies Glossary
Applications ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

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Connexin 30/GJB6 Antibody Summary

Description
Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.
Immunogen
Peptide with sequence C-RSKRAQTQKNHPNH corresponding to internal region according to NP_006774.2.
Epitope
internal region
Specificity
Reported variants represent identical protein: NP_006774.2, NP_001103691.1, NP_001103689.1, NP_001103690.1
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
GJB6
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Peptide ELISA Detection limit 1:16000
Application Notes
WB: Preliminary experiments gave an approx. 14 kDa band in human brain (cerebellum) and rat brain lysates after 1 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 30.4 kDa band according to NP_006774.2. The 14 kDa band was successfully blocked by incubation with the immunizing peptide.
Publications
Read Publication using NBP1-45247.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Connexin 30/GJB6 Antibody

  • Connexin 30
  • connexin-30
  • CX30
  • CX30gap junction protein, beta 6
  • DFNA3B
  • DFNB1B
  • ectodermal dysplasia 2, hidrotic (Clouston syndrome)
  • ED2
  • EDH
  • gap junction beta-6 protein
  • gap junction protein, beta 6 (connexin 30)
  • gap junction protein, beta 6, 30kDa
  • GJB6
  • HEDDFNA3

Background

The connexin gene family codes for the protein subunits of gap junction channels that mediate direct diffusion of ions and metabolites between the cytoplasm of adjacent cells. Connexins span the plasma membrane 4 times, with amino- and carboxy-terminal regions facing the cytoplasm. Connexin genes are expressed in a cell type-specific manner with overlapping specificity. The gap junction channels have unique properties depending on the type of connexins constituting the channel.[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Connexin 30/GJB6 Antibody (NBP1-45247)(1)

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Bioinformatics

Gene Symbol GJB6
Entrez
Uniprot