Complement Factor B Antibody

Complement factor B is a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease that associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 4 applications: ICC/IF, IHC-Fr, IHC-P, WB.

Showing Publications 1 - 7 of 7.

Publications using NBP1-89985	Applications	Species
Chen K, Deng Y, Shang S et al. Complement factor B inhibitor LNP023 improves lupus nephritis in MRL/lpr mice Biomedicine & Pharmacotherapy 2022-09-01 [PMID: 36076550] (IHC-P, WB, Mouse)	IHC-P, WB	Mouse
Kendall RT, Renaud L, Baatz JE et al. SSc biomarkers detection in the secretome of TGFbeta1-activated primary human lung fibroblasts Journal of proteomics 2021-04-27 [PMID: 33930553]
Lin CM, Titchenell PM, Keil JM et al. Inhibition of Atypical Protein Kinase C Reduces Inflammation-Induced Retinal Vascular Permeability. Am. J. Pathol. 2018-10-01 [PMID: 30220554] (ICC/IF, Rat)	ICC/IF	Rat
Yamanaka K, Kakuta Y, Miyagawa S et al. Depression of Complement Regulatory Factors in Rat and Human Renal Grafts Is Associated with the Progress of Acute T-Cell Mediated Rejection PLoS ONE 2016-03-01 [PMID: 26928779] (IHC-Fr, Rat)	IHC-Fr	Rat
Kato BS, Nicholson G, Neiman M et al. Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model. Proteome Sci 2011-11-17 [PMID: 22093360]
Cima I, Schiess R, Wild P et al. Cancer genetics-guided discovery of serum biomarker signatures for diagnosis and prognosis of prostate cancer. Proc Natl Acad Sci U S A 2011-02-22 [PMID: 21300890]
Singh MV, Kapoun A, Higgins L et al. Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart. J Clin Invest 2009-04-01 [PMID: 19273909]

Array NBP1-89985

• Complement Factor B Antibodies
• Complement Factor B ELISA Kits
• Complement Factor B Lysate
• Complement Factor B Proteins