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Claudin-18.2 Antibody (CLDN18.2/8141R) [Biotin]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clone
CLDN18.2/8141R
Clonality
Monoclonal
Host
Rabbit
Conjugate
Biotin

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP3-24137AF350
Alexa Fluor 405
NBP3-24137AF405
Alexa Fluor 488
NBP3-24137AF488
Alexa Fluor 532
NBP3-24137AF532
Alexa Fluor 594
NBP3-24137AF594
Alexa Fluor 647
NBP3-24137AF647
Alexa Fluor 700
NBP3-24137AF700
Alexa Fluor 750
NBP3-24137AF750
Allophycocyanin
NBP3-24137APC
CoraFluor 1
NBP3-24137CL1
DyLight 350
NBP3-24137UV
DyLight 405
NBP3-24137V
DyLight 488
NBP3-24137G
DyLight 550
NBP3-24137R
DyLight 594
NBP3-24137DL594
DyLight 650
NBP3-24137C
DyLight 680
NBP3-24137FR
DyLight 755
NBP3-24137IR
FITC
NBP3-24137F
HRP
NBP3-24137H
Janelia Fluor 525
NBP3-24137JF525
Janelia Fluor 549
NBP3-24137JF549
Janelia Fluor 585
NBP3-24137JF585
Janelia Fluor 635
NBP3-24137JF635
Janelia Fluor 646
NBP3-24137JF646
Janelia Fluor 669
NBP3-24137JF669
PE
NBP3-24137PE
PerCP
NBP3-24137PCP
Unconjugated
NBP3-24137
mFluor Violet 450 SE
NBP3-24137MFV450
mFluor Violet 500 SE
NBP3-24137MFV500
mFluor Violet 610 SE
NBP3-24137MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP3-24137
Azide and BSA Free
NBP3-24137
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Claudin-18.2 Antibody (CLDN18.2/8141R) [Biotin] Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
Recombinant fragment (around aa1-100) of human Claudin-18.2 protein (exact sequence is proprietary)
Localization
Cell junction, tight junction. Cell membrane.
Specificity
The claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the claudins, occludin and junction adhesion molecule. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Emerging evidence suggests that the claudin family of proteins regulates transport through tight junctions via differential discrimination for solute size and charge. Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions.
Isotype
IgG Kappa
Clonality
Monoclonal
Host
Rabbit
Gene
CLDN18
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Alternate Names for Claudin-18.2 Antibody (CLDN18.2/8141R) [Biotin]

  • claudin-18
  • SFTA5
  • SFTPJ
  • surfactant associated 5
  • surfactant associated protein J
  • surfactant, pulmonary associated protein J

Background

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Claudin-18.2
Antibody (CLDN18.2/81 ...
NBP3-24137B
Claudin-18.2 Antibody (CLDN18.2/8141R) [Biotin]
Species: Hu
Applications: IHC

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Bioinformatics

Gene Symbol CLDN18