CDX2 Antibody

CDX2 is a caudal type homeobox gene that encodes an intestine-specific transcription factor that is expressed early in intestinal development and may be involved in the regulation of proliferation and differentiation of intestinal epithelial cells. It is expressed in the nuclei of epithelial cells throughout the intestine, from duodenum to rectum. The CDX2 protein is expressed in primary and metastatic colorectal carcinomas and has also been demonstrated in the intestinal metaplasia of the stomach and intestinal-type gastric cancer, while it is not expressed in the normal gastric mucosa. Studies have shown that CDX2 is superior marker compared to CK20.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: ICC/IF, IF/IHC, IHC, IHC-P, MiAr.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using NB100-2136	Applications	Species
Mena-Osuna R, Mantrana A, Guil-Luna S et al. Metabolic shift underlies tumor progression and immune evasion in S-nitrosoglutathione reductase-deficient cancer The Journal of pathology 2023-04-05 [PMID: 37017456] (IHC, Human)	IHC	Human
Mochizuki K, Kudo SE, Kato K et al. Molecular and clinicopathological differences between depressed and protruded T2 colorectal cancer PloS one 2022-10-20 [PMID: 36264865] (IF/IHC, Human)	IF/IHC	Human
Adhikari D, Lee IW, Al-Zubaidi U et al. Depletion of oocyte dynamin-related protein 1 shows maternal-effect abnormalities in embryonic development Science advances 2022-06-17 [PMID: 35704569] (ICC/IF, Mouse)	ICC/IF	Mouse
Kasashima H, Duran A, Martinez-OrdoNez A et al. Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population Dev Cell 2020-11-10 [PMID: 33207226] (IF/IHC, Mouse)	IF/IHC	Mouse
Li Y, Yao Q, Zhang L et al. Immunohistochemistry-Based Consensus Molecular Subtypes as a Prognostic and Predictive Biomarker for Adjuvant Chemotherapy in Patients with Stage II Colorectal Cancer Oncologist 2020-09-14 [PMID: 32926498] (MiAr, Human)	MiAr	Human
Yao Y, Xu X, Yang L et al. Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer Cell Stem Cell 2019-11-19 [PMID: 31761724] (IF/IHC, Human)	IF/IHC	Human
Sandberg TP, Sweere I, van Pelt GW et al. Prognostic value of low CDX2 expression in colorectal cancers with a high stromal content - a short report Cell Oncol (Dordr) 2019-03-08 [PMID: 30847807] (IF/IHC, Human)	IF/IHC	Human
Trinh A, Trumpi K, de Sousa E Melo F et al. Practical and Robust Identification of Molecular Subtypes in Colorectal Cancer by Immunohistochemistry. Clin Cancer Res 2016-07-26 [PMID: 27459899]
De Sousa E Melo F, Wang X, Jansen M et al. Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions. Nat Med 2013-05-01 [PMID: 23584090] (IHC-P, Human)	IHC-P	Human
Kerschner JL, Harris A. Transcriptional networks driving enhancer function in the CFTR gene. Biochem J 2012-09-01 [PMID: 22671145]
Verzi MP, Shin H, Ho LL et al. Essential and redundant functions of caudal family proteins in activating adult intestinal genes. Mol Cell Biol 2011-05-01 [PMID: 21402776]
Verzi MP, Hatzis P, Sulahian R et al. TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions. Proc Natl Acad Sci U S A 2010-08-01 [PMID: 20696899]
Show All 12 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Bryan Tinsley	IHC	Human	04/21/2014	View Summary Application Immunohistochemistry Species Human

Array NB100-2136

• CDX2 Antibodies
• CDX2 ELISA Kits
• CDX2 Lysate
• CDX2 Proteins
• CDX2 ELISA