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CD46 Antibody (MEM-258) [Biotin]

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Product Details

Summary
Reactivity Hu, BvSpecies Glossary
Applications WB, Flow, IP
Clone
MEM-258
Clonality
Monoclonal
Host
Mouse
Conjugate
Biotin
Concentration
1.0 mg/ml

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB500-301AF350
Alexa Fluor 405
NB500-301AF405
Alexa Fluor 488
NB500-301AF488
Alexa Fluor 532
NB500-301AF532
Alexa Fluor 594
NB500-301AF594
Alexa Fluor 647
NB500-301AF647
Alexa Fluor 700
NB500-301AF700
Alexa Fluor 750
NB500-301AF750
Allophycocyanin
NB500-301APC
Allophycocyanin/Cy7
NB500-301APCCY7
CoraFluor 1
NB500-301CL1
DyLight 350
NB500-301UV
DyLight 405
NB500-301V
DyLight 488
NB500-301G
DyLight 550
NB500-301R
DyLight 594
NB500-301DL594
DyLight 650
NB500-301C
DyLight 680
NB500-301FR
DyLight 755
NB500-301IR
FITC
NB500-599
HRP
NB500-301H
Janelia Fluor 525
NB500-301JF525
Janelia Fluor 549
NB500-301JF549
Janelia Fluor 585
NB500-301JF585
Janelia Fluor 635
NB500-301JF635
Janelia Fluor 646
NB500-301JF646
Janelia Fluor 669
NB500-301JF669
PE
NB500-301PE
PE/Atto594
NB500-301PEATT594
PE/Cy5.5
NB500-301PECY55
PE/Cy7
NB500-301PECY7
PerCP
NB500-301PCP
Unconjugated
NB500-301
mFluor Violet 450 SE
NB500-301MFV450
mFluor Violet 500 SE
NB500-301MFV500
mFluor Violet 610 SE
NB500-301MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NB500-301
BSA Free
NB500-301
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CD46 Antibody (MEM-258) [Biotin] Summary

Immunogen
HPB-ALL human T cell line
Specificity
The antibody MEM-258 recognizes an epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein). CD46 is 56-66 kDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells and fibroblast; it is negative on erythrocytes.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CD46
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1-2 ug/ml
  • Immunoprecipitation 1:50
  • Western Blot 1:100-1:2000
Theoretical MW
66 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Readout System

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.4)
Preservative
0.9% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein A purified

Alternate Names for CD46 Antibody (MEM-258) [Biotin]

  • AHUS2
  • CD46 antigen
  • CD46 molecule, complement regulatory protein
  • CD46
  • MCP
  • membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
  • MIC10
  • TLXcomplement regulatory protein
  • trophoblast leucocyte common antigen
  • Trophoblast leukocyte common antigen
  • trophoblast-lymphocyte cross-reactive antigen

Background

CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CD46