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CD46 Antibody (MEM-258) [CoraFluor™ 1]

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Product Details

Summary
Reactivity Hu, BvSpecies Glossary
Applications WB, Flow, IP, CyTOF-ready
Clone
MEM-258
Clonality
Monoclonal
Host
Mouse
Conjugate
CoraFluor 1

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB500-301AF350
Alexa Fluor 405
NB500-301AF405
Alexa Fluor 488
NB500-301AF488
Alexa Fluor 532
NB500-301AF532
Alexa Fluor 594
NB500-301AF594
Alexa Fluor 647
NB500-301AF647
Alexa Fluor 700
NB500-301AF700
Alexa Fluor 750
NB500-301AF750
Allophycocyanin
NB500-301APC
Allophycocyanin/Cy7
NB500-301APCCY7
Biotin
NB500-602
DyLight 350
NB500-301UV
DyLight 405
NB500-301V
DyLight 488
NB500-301G
DyLight 550
NB500-301R
DyLight 594
NB500-301DL594
DyLight 650
NB500-301C
DyLight 680
NB500-301FR
DyLight 755
NB500-301IR
FITC
NB500-599
HRP
NB500-301H
Janelia Fluor 525
NB500-301JF525
Janelia Fluor 549
NB500-301JF549
Janelia Fluor 585
NB500-301JF585
Janelia Fluor 635
NB500-301JF635
Janelia Fluor 646
NB500-301JF646
Janelia Fluor 669
NB500-301JF669
PE
NB500-301PE
PE/Atto594
NB500-301PEATT594
PE/Cy5.5
NB500-301PECY55
PE/Cy7
NB500-301PECY7
PerCP
NB500-301PCP
Unconjugated
NB500-301
mFluor Violet 450 SE
NB500-301MFV450
mFluor Violet 500 SE
NB500-301MFV500
mFluor Violet 610 SE
NB500-301MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NB500-301
BSA Free
NB500-301
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CD46 Antibody (MEM-258) [CoraFluor™ 1] Summary

Description
CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
Immunogen
HPB-ALL human T cell line
Specificity
The antibody MEM-258 recognizes an epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein). CD46 is 56-66 kDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells and fibroblast; it is negative on erythrocytes.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CD46
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Immunoprecipitation
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark. Do not freeze.
Buffer
PBS
Preservative
No Preservative
Purity
Protein A purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for CD46 Antibody (MEM-258) [CoraFluor™ 1]

  • AHUS2
  • CD46 antigen
  • CD46 molecule, complement regulatory protein
  • CD46
  • MCP
  • membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
  • MIC10
  • TLXcomplement regulatory protein
  • trophoblast leucocyte common antigen
  • Trophoblast leukocyte common antigen
  • trophoblast-lymphocyte cross-reactive antigen

Background

CD46 is one of the membrane complement regulatory proteins. CD46 possesses C3b-binding and factor I cofactor activities which play important roles in regulation of complement activation pathway. CD46 is widely distributed on blood cells, endothelial cells, epithelial cells and tumor cell lines. CD46 exists as many isoforms in a variety of tissues. The antigen has a broad distribution and is present on leukocytes, platelets, endothelial cells, epithelial cells and fibroblasts. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. It is expressed on thymocytes, B cells, monocytes, granulocytes, NK cells, platelets, epithelial and endothelial cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CD46