CD161 Antibody (14F1F11) - BSA Free

CD161 is a C-Type Lectin Receptor, also known as NKR-P1A, previously found on NKT cells and subsets of T-cells. Phenotyping of cells that are functionally producing IL-17 has shown the one constant marker is CD161. While it had been shown previously that human CD4+ cells that produce both IL-17 and IFNg give rise to Th17/Th1 cells, indicating common etiology of these two T cell subsets, a clear marker for cells producing IL-17 is CD161. In fact, all cells characterized as the following subsets CD4+TCRab+, CD8+TCRab+, CD4-CD8-TCRab+, and CD4-CD8-TCRgd+ bearing CD161 also produce IL-17 but cells of these same phenotypes and functional marker which do not bear CD161 also do not produce IL-17. Induction of CD161 expression by transduction with RORC also induces IL-1R and IL-23R as well as the ability to produce IL-17. The ability to produce IL-17 and the induction of CD161 shows a strong dependency for RORC. Antibody to CD161 provides a probe for identifying IL-17 producing cells and offers a finer delineation of additional subsets derived from Th17 and their functional characteristics through cytokine mRNA expression or production.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IF/IHC.

Showing Publications 1 - 2 of 2.

Publications using NBP2-14845	Applications	Species
Abe T, Uosaki H, Shibata H, et al. Fetal sheep support the development of hematopoietic cells in vivo from human induced pluripotent stem cells Experimental hematology 2021-01-01 [PMID: 33395577] (IF/IHC, Human)	IF/IHC	Human
Tulic MK, Cavazza E, Cheli Y et al. Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo Nat Commun 2019-05-16 [PMID: 31097717] (IF/IHC, Human)	IF/IHC	Human

Array NBP2-14845

• CD161 Antibodies
• CD161 Lysate
• CD161 Proteins
• CD161 Proteins and Enzyme