CD161 Products

Description

Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 (CD161) protein contains an extracellular domain with several motifs characteristic of C type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. In mouse the NKRP1 family has three members, NKRP1A, B and C, whilst in human only one member has been identified. The human protein has received the designation CD161, and the mouse proteins have been referred to as CD161a, b and c. Engagement of CD161c has been reported to have activating function in NK cells, whilst engagement of CD161b is inhibitory.

Bioinformatics

Entrez	362443 Rat 3820 Human 683758 Rat
Uniprot	NP_002249 Human P27471 Rat Q12918 Human
Product By Gene ID	3820
Alternate Names	CD161 antigen CD161 CLEC5BC-type lectin domain family 5 member B hNKR-P1A HNKR-P1a killer cell lectin-like receptor subfamily B member 1 killer cell lectin-like receptor subfamily B, member 1 Natural killer cell surface protein P1A NKR-P1 NKR-P1AMGC138614 NKRP1ANKR

Research Areas for CD161

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Signal Transduction