Name: CCL5/RANTES Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF-278-NA
Rating: 4 (1 reviews)

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	WB, Simple Western, IHC, B/N, ICC/IF
Clonality	Polyclonal
Host	Goat
Conjugate	Unconjugated
Concentration	LYOPH

Catalog# & Conjugate	Size	Price
Biotin BAF278

Catalog# & Formulation	Size	Price
Carrier Free AF-278-SP

Conjugate	Catalog #	Availability	Size	Price
Biotin	BAF278

CCL5/RANTES Antibody [Unconjugated]

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Publications for CCL5/RANTES Antibody (AF-278-NA)(30)

Review for CCL5/RANTES Antibody (AF-278-NA) (1) 41

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Immunogen	E. coli-derived recombinant human CCL5/RANTES Ser24-Ser91 Accession # P13501
Specificity	Detects human CCL5/RANTES in direct ELISAs. Detects human CCL5/RANTES and mouse CCL5/RANTES Western blots. In direct ELISAs, approximately 40% cross-reactivity with recombinant canine CCL5/RANTES is observed and approximately 20% cross-reactivity with recombinant cotton rat CCL5/RANTES is observed. In Western blots, no cross-reactivity with recombinant human (rh) CCL3 and rhCCL4 is observed.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Goat
Gene	CCL5
Purity Statement	Antigen Affinity-purified
Endotoxin Note	<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

Publications using AF-278-NA	Applications	Species
Mathieu Claireaux, Rémy Robinot, Jérôme Kervevan, Mandar Patgaonkar, Isabelle Staropoli, Anne Brelot et al. Low CCR5 expression protects HIV-specific CD4+ T cells of elite controllers from viral entry Nature Communications 1/26/2022 [PMID: 35082297]
Gemma Sullivan, Paola Galdi, Nis Borbye-Lorenzen, David Q. Stoye, Gillian J. Lamb, Margaret J. Evans et al. Preterm Birth Is Associated With Immune Dysregulation Which Persists in Infants Exposed to Histologic Chorioamnionitis Frontiers in Immunology 8/27/2021 [PMID: 34512648]
MC Mladinich, JN Conde, WR Schutt, SY Sohn, ER Mackow Blockade of Autocrine CCL5 Responses Inhibits Zika Virus Persistence and Spread in Human Brain Microvascular Endothelial Cells MBio, 2021-08-17;12(4):e0196221. 2021-08-17 [PMID: 34399621] (Neutralization, Human)	Neutralization	Human
H Moreno, S Kunz The Protein Kinase Receptor Modulates the Innate Immune Response against Tacaribe Virus Viruses, 2021-07-07;13(7):. 2021-07-07 [PMID: 34372519] (Western Blot, Human)	Western Blot	Human
YF Sun, L Wu, SP Liu, MM Jiang, B Hu, KQ Zhou, W Guo, Y Xu, Y Zhong, XR Zhou, ZF Zhang, G Liu, S Liu, YH Shi, Y Ji, M Du, NN Li, GB Li, ZK Zhao, XY Huang, LQ Xu, QC Yu, DH Peng, SJ Qiu, HC Sun, M Dean, XD Wang, WY Chung, AR Dennison, J Zhou, Y Hou, J Fan, XR Yang Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma Nature Communications, 2021-07-02;12(1):4091. 2021-07-02 [PMID: 34215748] (IHC, Human)	IHC	Human
Xiaoting Li, Tian Fang, Sen Xu, Ping Jin, Dongchen Zhou, Zhengzheng Wang et al. PARP inhibitors promote stromal fibroblast activation by enhancing CCL5 autocrine signaling in ovarian cancer npj Precision Oncology 6/9/2021 [PMID: 34108603]
Yoshida T, Miura T, Matsumiya T et al. Toll-Like Receptor 3 as a Recurrence Risk Factor and a Potential Molecular Therapeutic Target in Colorectal Cancer Clin Exp Gastroenterol 10/2/2020 [PMID: 33061521]
Charlotte T. Rodrigues Neves, Sander W. Spiekstra, Niels P. J. de Graaf, Thomas Rustemeyer, Albert J. Feilzer, Cees J. Kleverlaan et al. Titanium salts tested in reconstructed human skin with integrated MUTZ ‐3‐derived Langerhans cells show an irritant rather than a sensitizing potential Contact Dermatitis 11/1/2020 [PMID: 32677096]
Leslie Frapin, Johann Clouet, Claire Chédeville, Constantin Moraru, Edouard Samarut, Nina Henry et al. Controlled release of biological factors for endogenous progenitor cell migration and intervertebral disc extracellular matrix remodelling Biomaterials 9/1/2020 [PMID: 32450408]
SK Singh, MK Mishra, IA Eltoum, S Bae, JW Lillard, R Singh CCR5/CCL5 axis interaction promotes migratory and invasiveness of pancreatic cancer cells Sci Rep, 2018-01-22;8(1):1323. 2018-01-22 [PMID: 29358632] (IHC-P, Human)	IHC-P	Human
Sensen Lin, Li Sun, Xiaodan Lyu, Xiongfei Ai, Danyu Du, Nan Su et al. Lactate-activated macrophages induced aerobic glycolysis and epithelial-mesenchymal transition in breast cancer by regulation of CCL5-CCR5 axis: a positive metabolic feedback loop Oncotarget 12/15/2017 [PMID: 29299159]
Rump L, Mattey D, Kehoe O, Middleton J An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium. Cytokine, 2017-09-01;97(0):133-140. 2017-09-01 [PMID: 28648867] (IHC-Fr, Human)	IHC-Fr	Human
Zsiros E, Duttagupta P, Dangaj D, Li H, Frank R, Garrabrant T, Hagemann I, Levine B, June C, Zhang L, Wang E, Marincola F, Bedognetti D, Powell D, Tanyi J, Feldman M, Kandalaft L, Coukos G The Ovarian Cancer Chemokine Landscape Is Conducive to Homing of Vaccine-Primed and CD3/CD28-Costimulated T Cells Prepared for Adoptive Therapy. Clin Cancer Res, 2015-02-23;21(12):2840-50. 2015-02-23 [PMID: 25712684] (IHC, Human)	IHC	Human
Shang L, Smith A, Duan L, Perkey K, Qu L, Wietgrefe S, Zupancic M, Southern P, Masek-Hammerman K, Reeves R, Johnson R, Haase A NK cell responses to simian immunodeficiency virus vaginal exposure in naive and vaccinated rhesus macaques. J Immunol, 2014-06-04;193(1):277-84. 2014-06-04 [PMID: 24899503] (IHC, Primate - Macaca mulatta (Rhesus Macaque))	IHC	Primate - Macaca mulatta (Rhesus Macaque)
Sirpa Salo, Carolina Bitu, Kalle Merkku, Pia Nyberg, Ibrahim O Bello, Jussi Vuoristo et al. Human Bone Marrow Mesenchymal Stem Cells Induce Collagen Production and Tongue Cancer Invasion PLoS ONE 10/21/2013 [PMID: 24204919]
Song K, Herzog B, Sheng M, Fu J, McDaniel J, Chen H, Ruan J, Xia L Lenalidomide inhibits lymphangiogenesis in preclinical models of mantle cell lymphoma. Cancer Res, 2013-10-24;73(24):7254-64. 2013-10-24 [PMID: 24158094] (Neutralization, Mouse)	Neutralization	Mouse
Sarkar SA, Lee CE, Victorino F, Nguyen TT, Walters JA, Burrack A, Eberlein J, Hildemann SK, Homann D Expression and regulation of chemokines in murine and human type 1 diabetes. Diabetes, 2011-12-30;61(2):436-46. 2011-12-30 [PMID: 22210319] (Flow Cytometry, Human)	Flow Cytometry	Human
Ouwehand K, Oosterhoff D, Breetveld M Irritant-induced migration of Langerhans cells coincides with an IL-10-dependent switch to a macrophage-like phenotype. J. Invest. Dermatol., 2010-11-11;131(2):418-25. 2010-11-11 [PMID: 21068755] (Neutralization, Human)	Neutralization	Human
Eberlein J, Nguyen TT, Victorino F, Golden-Mason L, Rosen HR, Homann D Comprehensive assessment of chemokine expression profiles by flow cytometry. J. Clin. Invest., 2010-02-08;120(3):907-23. 2010-02-08 [PMID: 20197626] (Flow Cytometry, Human)	Flow Cytometry	Human
Kim MJ, Romero R, Kim CJ, Tarca AL, Chhauy S, LaJeunesse C, Lee DC, Draghici S, Gotsch F, Kusanovic JP, Hassan SS, Kim JS Villitis of unknown etiology is associated with a distinct pattern of chemokine up-regulation in the feto-maternal and placental compartments: implications for conjoint maternal allograft rejection and maternal anti-fetal graft-versus-host disease. J. Immunol., 2009-03-15;182(6):3919-27. 2009-03-15 [PMID: 19265171] (IHC-Fr, Human)	IHC-Fr	Human
Renaud SJ, Sullivan R, Graham CH Tumour necrosis factor alpha stimulates the production of monocyte chemoattractants by extravillous trophoblast cells via differential activation of MAPK pathways. Placenta, 2009-02-08;30(4):313-9. 2009-02-08 [PMID: 19201463] (Neutralization, Human)	Neutralization	Human
Koenen RR, von Hundelshausen P, Nesmelova IV, Zernecke A, Liehn EA, Sarabi A, Kramp BK, Piccinini AM, Paludan SR, Kowalska MA, Kungl AJ, Hackeng TM, Mayo KH, Weber C Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice. Nat. Med., 2009-01-04;15(1):97-103. 2009-01-04 [PMID: 19122657] (Immunoprecipitation, Human)	Immunoprecipitation	Human
Weigt SS, Elashoff RM, Keane MP, Strieter RM, Gomperts BN, Xue YY, Ardehali A, Gregson AL, Kubak B, Fishbein MC, Saggar R, Ross DJ, Lynch JP, Zisman DA, Belperio JA Altered levels of CC chemokines during pulmonary CMV predict BOS and mortality post-lung transplantation. Am. J. Transplant., 2008-07-01;8(7):1512-22. 2008-07-01 [PMID: 18513272] (IHC-P, Human)	IHC-P	Human
Chou SY, Weng JY, Lai HL, Liao F, Sun SH, Tu PH, Dickson DW, Chern Y Expanded-polyglutamine huntingtin protein suppresses the secretion and production of a chemokine (CCL5/RANTES) by astrocytes. J. Neurosci., 2008-03-26;28(13):3277-90. 2008-03-26 [PMID: 18367595] (ICC, Human)	ICC	Human
Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, Richardson AL, Polyak K, Tubo R, Weinberg RA Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature, 2007-10-04;449(7162):557-63. 2007-10-04 [PMID: 17914389] (Neutralization, Human)	Neutralization	Human
Ali S, Malik G, Burns A, Robertson H, Kirby JA Renal transplantation: examination of the regulation of chemokine binding during acute rejection. Transplantation, 2005-03-27;79(6):672-9. 2005-03-27 [PMID: 15785373] (ICC, IHC-P, Human)	ICC, IHC-P	Human
Quandt J, Dorovini-Zis K The beta chemokines CCL4 and CCL5 enhance adhesion of specific CD4+ T cell subsets to human brain endothelial cells. J. Neuropathol. Exp. Neurol., 2004-04-01;63(4):350-62. 2004-04-01 [PMID: 15099025] (ICC, Human)	ICC	Human
Giunti D, Borsellino G, Benelli R, Marchese M, Capello E, Valle MT, Pedemonte E, Noonan D, Albini A, Bernardi G, Mancardi GL, Battistini L, Uccelli A Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS. J. Leukoc. Biol., 2003-05-01;73(5):584-90. 2003-05-01 [PMID: 12714572] (Neutralization, Human)	Neutralization	Human
Binninger-Schinzel D, 2019, Norley S, Adler HS, Oberg HH, Kurth R Simian immunodeficiency viruses with defective nef genes show increased susceptibility to the noncytotoxic antiviral activity of CD8+ lymphocytes. 2002-03-01;294(1):209-21. 2002-03-01 [PMID: 11886279] (Neutralization, Human)	Neutralization	Human
Sato E, Koyama S Bleomycin stimulates lung fibroblast and epithelial cell lines to release eosinophil chemotactic activity. Eur. Respir. J., 2000-11-01;16(5):951-8. 2000-11-01 [PMID: 11153598] (Neutralization, Human)	Neutralization	Human
Show All 30 Publications. Collapse Publications.

	Jan Martinek 11/15/2018
Application:	Immunofluorescence-Frozen
Species:	Human

Gene Symbol	CCL5
Uniprot	P13501()