CCL2/MCP1 Antibody (ECE.2)

Monocyte chemoattractant protein-1 (MCP-1) is a member of the chemokine-beta family of cytokines. The protein is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. It may play a inprotant role in the initiation and/or progression of pulmonary hypertension (PH). Blockade of a systemic MCP-1 signal pathway in vivo may prevent PH.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 3 applications: IF/IHC, IHC-P, WB.

Showing Publications 1 - 5 of 5.

Publications using NBP1-42312	Applications	Species
An L, Kim D, Donahue L et al. Sexual dimorphism in melanocyte stem cell behavior reveals combinational therapeutic strategies for cutaneous repigmentation bioRxiv 2023-05-23 [PMID: 37293072] (IHC-P, Mouse)	IHC-P	Mouse
Makabe K, Sugita S, Mandai M et al. Microglia dynamics in retinitis pigmentosa model: formation of fundus whitening and autofluorescence as an indicator of activity of retinal degeneration Scientific reports 2020-09-07 [PMID: 32895435] (IF/IHC, Mouse)	IF/IHC	Mouse
Pena CG, Nakada Y, Saatcioglu HD et al. LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment. J Clin Invest 2015-11-02 [PMID: 26413869] (WB)	WB
Zhu X, Westcott MM, Bi X et al. Myeloid Cell-Specific ABCA1 Deletion Protects Mice From Bacterial Infection Circ Res 2012-11-09 [PMID: 22955730] (IF/IHC, Mouse)	IF/IHC	Mouse
Kajii M, Suzuki C, Kashihara J et al. Prevention of excessive collagen accumulation by human intravenous immunoglobulin treatment in a murine model of bleomycin-induced scleroderma Clin Exp Immunol 2011-02-01 [PMID: 21091669] (IF/IHC, Mouse)	IF/IHC	Mouse

Array NBP1-42312

• CCL2/MCP1 Antibodies
• CCL2/MCP1 ELISA Kits
• CCL2/MCP1 Lysate
• CCL2/MCP1 Proteins