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CCL2/MCP1 Antibody (carlumab)

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Immobilized human CCL2/MCP1 His at 2 ug/mL can bind CCL2/MCP1 Antibody (carlumab), EC50=0.02438 ug/mL.
Immobilized human CCL2/MCP1 His at 2 ug/mL can bind CCL2/MCP1 Antibody (carlumab), EC50=0.02438 ug/mL.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, Flow, Func
Clone
carlumab
Clonality
Monoclonal
Host
Human
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP3-28134AF350
Alexa Fluor 405
NBP3-28134AF405
Alexa Fluor 488
NBP3-28134AF488
Alexa Fluor 532
NBP3-28134AF532
Alexa Fluor 594
NBP3-28134AF594
Alexa Fluor 647
NBP3-28134AF647
Alexa Fluor 700
NBP3-28134AF700
Alexa Fluor 750
NBP3-28134AF750
Allophycocyanin
NBP3-28134APC
Biotin
NBP3-28134B
CoraFluor 1
NBP3-28134CL1
DyLight 350
NBP3-28134UV
DyLight 405
NBP3-28134V
DyLight 488
NBP3-28134G
DyLight 550
NBP3-28134R
DyLight 594
NBP3-28134DL594
DyLight 650
NBP3-28134C
DyLight 680
NBP3-28134FR
DyLight 755
NBP3-28134IR
FITC
NBP3-28134F
HRP
NBP3-28134H
Janelia Fluor 525
NBP3-28134JF525
Janelia Fluor 549
NBP3-28134JF549
Janelia Fluor 646
NBP3-28134JF646
Janelia Fluor 669
NBP3-28134JF669
PE
NBP3-28134PE
PerCP
NBP3-28134PCP
mFluor Violet 450 SE
NBP3-28134MFV450
mFluor Violet 500 SE
NBP3-28134MFV500
mFluor Violet 610 SE
NBP3-28134MFV610
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CCL2/MCP1 Antibody (carlumab) Summary

Description
Expressed from CHO. The heavy chain type is huIgG1, and the light chain type is hukappa. It has a predicted MW of 145.5 kDa.

Also known as 'carlumab'.

Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.
Additional Information
Recombinant Monoclonal Antibody
Immunogen
CCL2 / MCP1
Isotype
IgG1
Clonality
Monoclonal
Host
Human
Gene
CCL2
Purity
Protein A purified
Endotoxin Note
< 0.001EU/ug,determined by LAL method.
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Applications/Dilutions

Dilutions
  • ELISA
  • Flow Cytometry
  • Functional

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A purified
Reconstitution Instructions
Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Alternate Names for CCL2/MCP1 Antibody (carlumab)

  • C-C motif chemokine 2
  • chemokine (C-C motif) ligand 2
  • GDCF-2
  • HC11Monocyte secretory protein JE
  • MCAFMonocyte chemotactic and activating factor
  • MCP1 Monocyte chemotactic protein 1
  • MCP-1 Small-inducible cytokine A2
  • MGC9434
  • Monocyte chemoattractant protein 1
  • monocyte chemoattractant protein-1
  • SCYA2HSMCR30
  • small inducible cytokine A2 (monocyte chemotactic protein 1, homologous tomouse Sig-je)
  • small inducible cytokine subfamily A (Cys-Cys), member 2
  • SMC-CF

Background

Monocyte Chemoattracctant Protein-1 (MCP1), also known as CCL2, is produced by a wide range of cell types as a reaction to diverse inflammatory stimuli and is a chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. MCP1 augments monocyte anti-tumor activity and has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. In atherosclerosis MCP-1 has been implicated to be involved in the recruitment of monocytes into the arterial wall during the disease process.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Species: Bv, Hu, Mu
Applications: CyTOF-ready, ICC, IHC, ICFlow

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Secondary Antibodies

 

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MCP-1 - chemoattractant protein involed in monocyte migration and infiltration
Monocyte chemotractant protein-1 (MCP-1), also known as CCL2, is a key chemokine involved in the migration of monocytes and macrophages to sites of active inflammation. It is a member of the C-C/beta family of cytokines, characterized by the Cys-C...  Read full blog post.
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Bioinformatics

Gene Symbol CCL2
Uniprot