CCL18/PARC Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CCL18, also known as alternative macrophage activation-associated CC chemokine (AMAC)-1, macrophage inflammatory protein (MIP)-4, and dendritic cell chemokine (DC-CK1), is a novel CC chemokine that is highly homologous to MIP-1 alpha (61% amino acid (aa) sequence identity). CCL18 cDNA encodes an 89 aa residue precursor protein with a 20 aa putative signal peptide that is cleaved to generate a 69 aa residue mature protein which lacks potential glycosylation sites. In vitro, CCL18 mRNA expression is induced in alternatively activated macrophages by Th2 cytokines such as IL-4, IL-10, and IL-13, and inhibited by IFN‑ gamma . CCL18 mRNA is also expressed by GM-CSF/IL-4-induced monocyte-derived dendritic cells. In vivo, CCL18 is highly expressed in lung and placenta but is not expressed in epidermal Langerhans cells. Recombinant CCL18 has been shown to chemoattract naive T cells but not monocytes or neutrophils.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: IHC, IHC-P, In Vivo, Neutralization, Western Blot.

Showing Publications 1 - 7 of 7.

Publications using AF394	Applications	Species
W Zeng, L Xiong, W Wu, S Li, J Liu, L Yang, L Lao, P Huang, M Zhang, H Chen, N Miao, Z Lin, Z Liu, X Yang, J Wang, P Wang, E Song, Y Yao, Y Nie, J Chen, D Huang CCL18 signaling from tumor-associated macrophages activates fibroblasts to adopt a chemoresistance-inducing phenotype Oncogene, 2022-11-22;0(0):. 2022-11-22 [PMID: 36418470] (IHC, In Vivo, Human, Mouse)	IHC, In Vivo	Human, Mouse
Andrew C. Little, Pragathi Pathanjeli, Zhifen Wu, Liwei Bao, Laura E. Goo, Joel A. Yates et al. IL-4/IL-13 Stimulated Macrophages Enhance Breast Cancer Invasion Via Rho-GTPase Regulation of Synergistic VEGF/CCL-18 Signaling Frontiers in Oncology 5/31/2019 [PMID: 31214501]
Momohara S, Okamoto H, Iwamoto T, Mizumura T, Ikari K, Kawaguchi Y, Takeuchi M, Kamatani N, Tomatsu T High CCL18/PARC expression in articular cartilage and synovial tissue of patients with rheumatoid arthritis. J. Rheumatol., 2007-02-01;34(2):266-71. 2007-02-01 [PMID: 17304652] (IHC-P, Human)	IHC-P	Human
Chang Y, Senechal S, de Nadai P, Chenivesse C, Gilet J, Vorng H, Legendre B, Tonnel AB, Wallaert B, Lassalle P, Tsicopoulos A Diesel exhaust exposure favors TH2 cell recruitment in nonatopic subjects by differentially regulating chemokine production. J. Allergy Clin. Immunol., 2006-06-21;118(2):354-60. 2006-06-21 [PMID: 16890758] (Neutralization, Human)	Neutralization	Human
Luzina IG, Papadimitriou JC, Anderson R, Pochetuhen K, Atamas SP Induction of prolonged infiltration of T lymphocytes and transient T lymphocyte-dependent collagen deposition in mouse lungs following adenoviral gene transfer of CCL18. Arthritis Rheum., 2006-08-01;54(8):2643-55. 2006-08-01 [PMID: 16868995] (Western Blot, Human)	Western Blot	Human
Gunther C, Bello-Fernandez C, Kopp T, Kund J, Carballido-Perrig N, Hinteregger S, Fassl S, Schwarzler C, Lametschwandtner G, Stingl G, Biedermann T, Carballido JM CCL18 is expressed in atopic dermatitis and mediates skin homing of human memory T cells. J. Immunol., 2005-02-01;174(3):1723-8. 2005-02-01 [PMID: 15661937] (IHC, Human)	IHC	Human
Pivarcsi A, Gombert M, Dieu-Nosjean MC, Kubitza R, Meller S, Rieker J, Muller A, Da Cunha L, Haahtela A, Sonkoly E, Fridman WH, Alenius H, Kemeny L, Ruzicka T, Zlotnik A CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure. J. Immunol., 2004-11-01;173(9):5810-7. 2004-11-01 [PMID: 15494534] (IHC, Human)	IHC	Human

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	WB	Other	01/08/2015	View Summary Application Western Blot Sample Tested See PMID 23874339 Species Other

Array AF394

• CCL18/PARC Antibodies
• CCL18/PARC Lysate
• CCL18/PARC Protein
• CCL18/PARC Proteins and Enzymes
• CCL18/PARC ELISAs