Caspase-3 Antibody (269518) [Unconjugated] - Cleaved (Asp175)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Caspase-3 (Cysteine-aspartic acid protease 3/Casp3; also Yama, apopain and CPP32) is a 29 kDa heterodimer that belongs to the peptidase C14A family of enzymes. It is widely expressed and considered to be the major executioner caspase in the apoptotic cascade. Human procaspase-3 is a 32 kDa, 277 amino acid (aa) protein and is normally an inactive homodimer. Following cell stress/activation, procaspase-3 undergoes proteolysis to generate an N-terminal 148 aa p17/17 kDa subunit (aa 29-175), plus a 102 aa C-terminal p12/12 kDa subunit. These subunits noncovalently heterodimerize, and associate with another p17/p12 heterodimer to form an active enzyme. There is one potential variant that shows an alternative start site nine aa upstream of the standard start site coupled with a 21 aa substitution for aa 162-277. Over aa 29-175, human and mouse caspase-3 share 87% aa identity.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Porcine, Xenograft.

We have publications tested in 10 applications: Dot Blot, Flow Cytometry, ICC, ICC/IF, IF, IHC, IHC-Fr, IHC-P, Immunohistochemistry, Western Blot.

Showing Publications 1 - 10 of 99. Show All 99 Publications. Collapse Publications.

Publications using MAB835	Applications	Species
Heffer, A;Lee, C;Holt, JC;Kiernan, AE; Notch1 is required to maintain supporting cell identity and vestibular function during maturation of the mammalian balance organs bioRxiv : the preprint server for biology 2024-06-21 [PMID: 38948821] (Immunohistochemistry, Mouse)	Immunohistochemistry	Mouse
Yoon, Y;Kim, CW;Kim, MY;Baik, SK;Jung, PY;Eom, YW; Interferon-? Overexpression in Adipose Tissue-Derived Stem Cells Induces HepG2 and Macrophage Cell Death in Liver Tumor Organoids via Induction of TNF-Related Apoptosis-Inducing Ligand Expression International journal of molecular sciences 2024-01-22 [PMID: 38279326] (Western Blot, IHC, Human)	Western Blot, IHC	Human
Donovan J, Deng Z, Bian F et al. Improving anti-tumor efficacy of low-dose Vincristine in rhabdomyosarcoma via the combination therapy with FOXM1 inhibitor RCM1 Frontiers in oncology 2023-02-02 [PMID: 36816948]
Donovan J, Deng Z, Bian F et al. Improving anti-tumor efficacy of low-dose Vincristine in rhabdomyosarcoma via the combination therapy with FOXM1 inhibitor RCM1 Frontiers in oncology 2/2/2023 [PMID: 36816948]
Kerry S. Wadey, Alexandros Somos, Genevieve Leyden, Hazel Blythe, Jeremy Chan, Lawrence Hutchinson et al. Pro-inflammatory role of Wnt/ beta -catenin signaling in endothelial dysfunction Frontiers in Cardiovascular Medicine 1/17/2023 [PMID: 36794234]
Rohli KE, Boyer CK, Bearrows SC et al. ER Redox Homeostasis Regulates Proinsulin Trafficking and Insulin Granule Formation in the Pancreatic Islet beta-Cell Function (Oxford, England) 9/28/2022 [PMID: 36325514]
Y Kaibori, D Nagakubo CCR3 blockage elicits polyploidization associated with the signatures of epithelial-mesenchymal transition in carcinoma cell lines Cancer Gene Therapy, 2022-09-19;0(0):. 2022-09-19 [PMID: 36123391] (ICC, Human)	ICC	Human
D Andrijevic, Z Vrselja, T Lysyy, S Zhang, M Skarica, A Spajic, D Dellal, SL Thorn, RB Duckrow, S Ma, PQ Duy, AU Isiktas, D Liang, M Li, SK Kim, SG Daniele, K Banu, S Perincheri, MC Menon, A Huttner, KN Sheth, KT Gobeske, GT Tietjen, HP Zaveri, SR Latham, AJ Sinusas, N Sestan Cellular recovery after prolonged warm ischaemia of the whole body Nature, 2022-08-03;608(7922):405-412. 2022-08-03 [PMID: 35922506] (IHC, Human)	IHC	Human
Yang Gao, Bin Chen, Ruru Wang, An Xu, Lijun Wu, Huayi Lu et al. Knockdown of RRM1 in tumor cells promotes radio-/chemotherapy induced ferroptosis by regulating p53 ubiquitination and p21-GPX4 signaling axis Cell Death Discovery 8/1/2022 [PMID: 35915092]
A Bagán, JA Morales-Ga, C Griñán-Fer, C Díaz, J Pérez Del, MC Ramos, F Vicente, B Pérez, J Brea, MI Loza, M Pallàs, C Escolano Insights into the Pharmacokinetics and In Vitro Cell-Based Studies of the Imidazoline I2 Receptor Ligand B06 International Journal of Molecular Sciences, 2022-05-12;23(10):. 2022-05-12 [PMID: 35628219] (Western Blot, Human)	Western Blot	Human
SM Zhang, WL Cai, X Liu, D Thakral, J Luo, LH Chan, MK McGeary, E Song, KRM Blenman, G Micevic, S Jessel, Y Zhang, M Yin, CJ Booth, LB Jilaveanu, W Damsky, M Sznol, HM Kluger, A Iwasaki, MW Bosenberg, Q Yan KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements Nature, 2021-10-20;598(7882):682-687. 2021-10-20 [PMID: 34671158] (IHC, Mouse)	IHC	Mouse
Ricardo Viais, Marcos Fariña-Mosquera, Marina Villamor-Payà, Sadanori Watanabe, Lluís Palenzuela, Cristina Lacasa et al. Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development eLife 8/24/2021 [PMID: 34427181]
CE Hippee, BK Singh, AL Thurman, AL Cooney, AA Pezzulo, R Cattaneo, PL Sinn Measles virus exits human airway epithelia within dislodged metabolically active infectious centers PloS Pathogens, 2021-08-12;17(8):e1009458. 2021-08-12 [PMID: 34383863] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Y Koda, T Teratani, PS Chu, Y Hagihara, Y Mikami, Y Harada, H Tsujikawa, K Miyamoto, T Suzuki, N Taniki, T Sujino, M Sakamoto, T Kanai, N Nakamoto CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells Nature Communications, 2021-07-22;12(1):4474. 2021-07-22 [PMID: 34294714] (IHC, Mouse)	IHC	Mouse
Neha Sharda, Tamaki Ikuse, Elizabeth Hill, Sonia Garcia, Steven J Czinn, Andrea Bafford et al. Impact of Andrographolide and Melatonin Combinatorial Drug Therapy on Metastatic Colon Cancer Cells and Organoids Clin Med Insights Oncol 6/4/2021 [PMID: 34158803]
Bhowmick S, Malat A, Caruso D Et Al. Intercellular Adhesion Molecule-1-Induced Posttraumatic Brain Injury Neuropathology in the Prefrontal Cortex and Hippocampus Leads to Sensorimotor Function Deficits and Psychological Stress eNeuro 7/16/2021 [PMID: 34135004]
Lidia F. Hernandez, Angie B. Dull, Soumya Korrapati, Christina M. Annunziata Smac-mimetic enhances antitumor effect of standard chemotherapy in ovarian cancer models via Caspase 8-independent mechanism Cell Death Discovery 6/4/2021 [PMID: 34088893]
Y Pan, JD Hysinger, T Barron, NF Schindler, O Cobb, X Guo, B Yalç?n, C Anastasaki, SB Mulinyawe, A Ponnuswami, S Scheaffer, Y Ma, KC Chang, X Xia, JA Toonen, JJ Lennon, EM Gibson, JR Huguenard, LM Liau, JL Goldberg, M Monje, DH Gutmann NF1 mutation drives neuronal�activity-dependent initiation of optic glioma Nature, 2021-05-26;594(7862):277-282. 2021-05-26 [PMID: 34040258] (Western Blot, Mouse)	Western Blot	Mouse
AT Kwok, NS Mohamed, JF Plate, RR Yammani, S Rosas, TA Bateman, E Livingston, JE Moore, BA Kerr, J Lee, CM Furdui, L Tan, ML Bouxsein, VL Ferguson, LS Stodieck, DC Zawieja, MD Delp, XW Mao, JS Willey Spaceflight and hind limb unloading induces an arthritic phenotype in knee articular cartilage and menisci of rodents Scientific Reports, 2021-05-18;11(1):10469. 2021-05-18 [PMID: 34006989] (Western Blot, Mouse)	Western Blot	Mouse
Y Zhong, XY Li, F Zhou, YJ Cai, R Sun, RP Liu Ziyuglycoside II inhibits the growth of digestive system cancer cells through multiple mechanisms Chinese journal of natural medicines, 2021-05-01;19(5):351-363. 2021-05-01 [PMID: 33941340] (Western Blot, Human)	Western Blot	Human
JUNKI HARADA, YASUYOSHI MIYATA, KYOHEI ARAKI, TSUYOSHI MATSUDA, YOSHIAKI NAGASHIMA, YUTA MUKAE et al. Pathological Significance and Prognostic Roles of Thrombospondin-3, 4 and 5 in Bladder Cancer In Vivo 2/5/2021 [PMID: 33910854]
AK Persaud, S Nair, MF Rahman, R Raj, B Weadick, D Nayak, C McElroy, M Shanmugam, S Knoblaugh, X Cheng, R Govindaraj Facilitative lysosomal transport of bile acids alleviates ER stress in mouse hematopoietic precursors Nature Communications, 2021-02-23;12(1):1248. 2021-02-23 [PMID: 33623001] (ICC/IF, Mouse)	ICC/IF	Mouse
C De Marco, P Zoppoli, N Rinaldo, S Morganella, M Morello, V Zuccalà, MV Carriero, D Malanga, R Chirillo, P Bruni, C Malzoni, D Di Vizio, R Venturella, F Zullo, A Rizzuto, M Ceccarelli, G Ciliberto, G Viglietto Genome-wide analysis of copy number alterations led to the characterisation of PDCD10 as oncogene in ovarian cancer Translational Oncology, 2021-01-27;14(3):101013. 2021-01-27 [PMID: 33516089] (Western Blot, Human)	Western Blot	Human
J Nouws, F Wan, E Finnemore, W Roque, SJ Kim, IS Bazan, CX Li, CM Sköld, Q Dai, X Yan, M Chioccioli, V Neumeister, CJ Britto, J Sweasy, RS Bindra, ÅM Wheelock, JL Gomez, N Kaminski, PJ Lee, M Sauler MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease JCI Insight, 2021-01-25;0(0):. 2021-01-25 [PMID: 33290275] (IHC, Mouse)	IHC	Mouse
A Dey, SMA Islam, R Patel, M Acevedo-Du The interruption of atypical PKC signaling and Temozolomide combination therapy against glioblastoma Cell Signal, 2020-11-02;77(0):109819. 2020-11-02 [PMID: 33147518] (Western Blot, Human)	Western Blot	Human
Hailong You, Yao Jin, Jinsong Kang, Ying Mao, Jing Su, Liankun Sun et al. Mitochondrial serine protease Omi/HtrA2 accentuates brain ischemia/reperfusion injury in rats and oxidative stress injury in vitro by modulating mitochondrial stress proteins CHOP and ClpP and physically interacting with mitochondrial fusion protein OPA1 Bioengineered 10/5/2020 [PMID: 33016225]
Yang Gao, Pengbo Wen, Bin Chen, Guanshuo Hu, Lijun Wu, An Xu et al. Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor Cells International Journal of Molecular Sciences 9/12/2020 [PMID: 32932732]
J Usui, M Yaguchi, S Yamazaki, M Takahashi-, T Kawamura, S Kaneko, SV Seshan, P Ronco, K Yamagata Transcription factor 21 expression in injured podocytes of glomerular diseases Sci Rep, 2020-07-13;10(1):11516. 2020-07-13 [PMID: 32661376] (Western Blot, Human)	Western Blot	Human
C Buhrmann, AB Kunnumakka, B Popper, M Majeed, BB Aggarwal, M Shakibaei Calebin A Potentiates the Effect of 5-FU and TNF-&beta (Lymphotoxin &alpha) against Human Colorectal Cancer Cells: Potential Role of NF-&kappaB Int J Mol Sci, 2020-03-31;21(7):. 2020-03-31 [PMID: 32244288] (IF, Human)	IF	Human
Sun L, Zhu M, Feng W, et al. Exosomal miRNA Let-7 from Menstrual Blood-Derived Endometrial Stem Cells Alleviates Pulmonary Fibrosis through Regulating Mitochondrial DNA Damage Oxidative Medicine and Cellular Longevity 12/17/2019 [PMID: 31949877]
Lihan Xie, Asavari Rajpurkar, Ellen Quarles, Nicole Taube, Akash S. Rai, Jake Erba et al. Accumulation of Nucleolar Inorganic Polyphosphate Is a Cellular Response to Cisplatin-Induced Apoptosis Frontiers in Oncology 12/12/2019 [PMID: 31921667]
LB Jones, S Kumar, CR Bell, VA Peoples, BJ Crenshaw, MT Coats, JA Scoffield, GC Rowe, B Sims, QL Matthews Effects of Pseudomonas aeruginosa on Microglial-Derived Extracellular Vesicle Biogenesis and Composition Pathogens, 2019-12-14;8(4):. 2019-12-14 [PMID: 31847332] (Dot Blot, Mouse)	Dot Blot	Mouse
G Li, X Wang, C Li, S Hu, Z Niu, Q Sun, M Sun Piwi-Interacting RNA1037 Enhances Chemoresistance and Motility in Human Oral Squamous Cell Carcinoma Cells Onco Targets Ther, 2019-12-04;12(0):10615-10627. 2019-12-04 [PMID: 31824169] (Western Blot, Xenograft)	Western Blot	Xenograft
E Simader, L Beer, M Laggner, V Vorstandle, A Gugerell, M Erb, P Kalinina, D Copic, D Moser, A Spittler, E Tschachler, H Jan Ankers, M Mildner Tissue-regenerative potential of the secretome of gamma-irradiated peripheral blood mononuclear cells is mediated via TNFRSF1B-induced necroptosis Cell Death Dis, 2019-09-30;10(10):729. 2019-09-30 [PMID: 31570701] (Western Blot, Human)	Western Blot	Human
S Giraud, C Steichen, P Couturier, S Tillet, V Mallet, R Coudroy, JM Goujon, P Hannaert, T Hauet Influence of Hypoxic Preservation Temperature on Endothelial Cells and Kidney Integrity Biomed Res Int, 2019-06-04;2019(0):8572138. 2019-06-04 [PMID: 31275986] (IHC-P, Porcine)	IHC-P	Porcine
Ajeetha Josephrajan, Ann V. Hertzel, Ellie K. Bohm, Michael W. McBurney, Shin-Ichiro Imai, Douglas G. Mashek et al. Unconventional Secretion of Adipocyte Fatty Acid Binding Protein 4 Is Mediated By Autophagic Proteins in a Sirtuin-1–Dependent Manner Diabetes 9/1/2019 [PMID: 31171562]
E Sohn, HS Lim, YJ Kim, BY Kim, JH Kim, SJ Jeong Elaeagnus glabra f. oxyphylla Attenuates Scopolamine-Induced Learning and Memory Impairments in Mice by Improving Cholinergic Transmission via Activation of CREB/NGF Signaling Nutrients, 2019-05-28;11(6):. 2019-05-28 [PMID: 31141948] (Western Blot, Mouse)	Western Blot	Mouse
KR Greenow, M Zverev, S May, H Kendrick, GT Williams, T Phesse, L Parry Lect2 deficiency is characterised by altered cytokine levels and promotion of intestinal tumourigenesis Oncotarget, 2018-11-23;9(92):36430-36443. 2018-11-23 [PMID: 30559928] (IHC, Mouse)	IHC	Mouse
H Zahednasab, M Firouzi, S Kaboudania, Z Mojallal-T, S Karampour, H Keyvani The protective effect of rifampicin on behavioral deficits, biochemical, and neuropathological changes in a cuprizone model of demyelination Cytokine, 2018-10-24;113(0):417-426. 2018-10-24 [PMID: 30539784] (Western Blot, Mouse)	Western Blot	Mouse
Lindi Chen, Fabio Pastorino, Philip Berry, Jennifer Bonner, Calum Kirk, Katrina M. Wood et al. Preclinical evaluation of the first intravenous small molecule MDM2 antagonist alone and in combination with temozolomide in neuroblastoma International Journal of Cancer 6/15/2019 [PMID: 30536898]
D Liu, T Li, H Luo, X Zuo, S Liu, S Wu The effect of the cholinergic anti-inflammatory pathway on collagen-induced arthritis involves the modulation of dendritic cell differentiation Arthritis Res. Ther., 2018-11-28;20(1):263. 2018-11-28 [PMID: 30486874] (Western Blot, Mouse)	Western Blot	Mouse
ZP You, MJ Yu, YL Zhang, K Shi Progranulin protects the mouse retina under hypoxic conditions via inhibition of the Toll?like receptor?4?NADPH oxidase 4 signaling pathway Mol Med Rep, 2018-11-08;0(0):. 2018-11-08 [PMID: 30431085] (Western Blot, Mouse)	Western Blot	Mouse
Nair RR, koivisto H, Jokivarsi k et al. Impaired mitochondrial fatty acid synthesis leads to neurodegeneration in mice. J. Neurosci. 9/28/2018 [PMID: 30266742]
T Rahim, P Becquart, ME Baeva, J Quandt Expression of the neuroprotective protein aryl hydrocarbon receptor nuclear translocator 2 correlates with neuronal stress and disability in models of multiple sclerosis J Neuroinflammation, 2018-09-19;15(1):270. 2018-09-19 [PMID: 30231889] (ICC, Rat)	ICC	Rat
R Hamon, HB Tran, E Roscioli, M Ween, H Jersmann, S Hodge Bushfire smoke is pro-inflammatory and suppresses macrophage phagocytic function Sci Rep, 2018-09-07;8(1):13424. 2018-09-07 [PMID: 30194323] (ICC, Human)	ICC	Human
Vladimir Ustiyan, Craig Bolte, Yufang Zhang, Lu Han, Yan Xu, Katherine E. Yutzey et al. FOXF1 transcription factor promotes lung morphogenesis by inducing cellular proliferation in fetal lung mesenchyme Developmental Biology 11/1/2018 [PMID: 30153454]
Guangye Han, Xinjun Zhang, Pei Liu, Quanfeng Yu, Zeyu Li, Qinnan Yu et al. Knockdown of anti-silencing function 1B histone chaperone induces cell apoptosis via repressing PI3K/Akt pathway in prostate cancer International Journal of Oncology 8/16/2018 [PMID: 30132513]
P Shen, J Chen, M Pan The protective effects of total paeony glycoside on ischemia/reperfusion injury in H9C2 cells via inhibition of the PI3K/Akt signaling pathway Mol Med Rep, 2018-07-30;18(3):3332-3340. 2018-07-30 [PMID: 30066927] (Western Blot, Rat)	Western Blot	Rat
Angie B. Dull, Deborah Wilsker, Melinda Hollingshead, Christina Mazcko, Christina M. Annunziata, Amy K. LeBlanc et al. Development of a quantitative pharmacodynamic assay for apoptosis in fixed tumor tissue and its application in distinguishing cytotoxic drug—induced DNA double strand breaks from DNA double strand breaks associated with apoptosis Oncotarget 3/30/2018 [PMID: 29682208]
LG Que, Z Yang, NL Lugogo, RK Katial, SA Shoemaker, JM Troha, DM Rodman, RM Tighe, M Kraft Effect of the S-nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma Immun Inflamm Dis, 2018-04-11;0(0):. 2018-04-11 [PMID: 29642282] (Western Blot, Mouse)	Western Blot	Mouse
RL Rausch, RT Libby, AE Kiernan Trabecular meshwork morphogenesis: A comparative analysis of wildtype and anterior segment dysgenesis mouse models Exp. Eye Res., 2018-02-13;0(0):. 2018-02-13 [PMID: 29452107] (IHC-Fr, Mouse)	IHC-Fr	Mouse
BS Moon, J Bai, M Cai, C Liu, J Shi, W Lu Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis Nat Commun, 2018-01-26;9(1):401. 2018-01-26 [PMID: 29374155] (IHC, Mouse)	IHC	Mouse
A Shaalan, G Carpenter, G Proctor Caspases are key regulators of inflammatory and innate immune responses mediated by TLR3 in vivo Mol. Immunol., 2018-01-11;94(0):190-199. 2018-01-11 [PMID: 29331803] (IHC-P, Mouse)	IHC-P	Mouse
Saurav Bhowmick, Veera D‘Mello, Nizmi Ponery, P. M. Abdul-Muneer Neurodegeneration and Sensorimotor Deficits in the Mouse Model of Traumatic Brain Injury Brain Sciences 1/6/2018 [PMID: 29316623]
X Wang, W Liu, D Zhuang, S Hong, J Chen Sestrin2 and sestrin3 suppress NK-92 cell-mediated cytotoxic activity on ovarian cancer cells through AMPK and mTORC1 signaling Oncotarget, 2017-10-04;8(52):90132-90143. 10/4/2017 [PMID: 29163816]
Chang-Yun Liu, Zhen-Hua Zhao, Zhi-Ting Chen, Chun-Hui Che, Zhang-Yu Zou, Xiao-Min Wu et al. DL-3-n-butylphthalide protects endothelial cells against advanced glycation end product-induced injury by attenuating oxidative stress and inflammation responses Experimental and Therapeutic Medicine 9/1/2017 [PMID: 28962149]
K.S. Wadey, B.A. Brown, G.B. Sala-Newby, P.-S. Jayaraman, K. Gaston, S.J. George Protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism Vascular Pharmacology 12/1/2017 [PMID: 28927755]
L Zhang, Y Yang, S Li, S Zhang, X Zhu, Z Tai, M Yang, Y Liu, X Guo, B Chen, Z Jiang, F Lu, X Zhu Loss of Tmem30a leads to photoreceptor degeneration Sci Rep, 2017-08-24;7(1):9296. 2017-08-24 [PMID: 28839191] (IHC, Mouse)	IHC	Mouse
H Zhang, H Yan, X Zhou, H Wang, Y Yang, J Zhang, H Wang The protective effects of Resveratrol against radiation-induced intestinal injury BMC Complement Altern Med, 2017-08-16;17(1):410. 2017-08-16 [PMID: 28814292] (IHC-P, Mouse)	IHC-P	Mouse
F Sallustio, C Curci, A Aloisi, CC Toma, E Marulli, G Serino, SN Cox, G De Palma, A Stasi, C Divella, R Rinaldi, FP Schena Inhibin-A and Decorin Secreted by Human Adult Renal Stem/Progenitor Cells Through the TLR2 Engagement Induce Renal Tubular Cell Regeneration Sci Rep, 2017-08-15;7(1):8225. 2017-08-15 [PMID: 28811645] (Flow Cytometry, ICC, Human)	Flow Cytometry, ICC	Human
S Janczar, J Nautiyal, Y Xiao, E Curry, M Sun, E Zanini, AJ Paige, H Gabra WWOX sensitises ovarian cancer cells to paclitaxel via modulation of the ER stress response Cell Death Dis, 2017-07-27;8(7):e2955. 2017-07-27 [PMID: 28749468] (Western Blot, Human)	Western Blot	Human
N Prevete, F Liotti, A Illiano, A Amoresano, P Pucci, A de Paulis, RM Melillo Formyl peptide receptor 1 suppresses gastric cancer angiogenesis and growth by exploiting inflammation resolution pathways Oncoimmunology, 2017-02-21;6(4):e1293213. 2017-02-21 [PMID: 28507800] (IHC-P, Human)	IHC-P	Human
K Sato, R Shirai, M Hontani, R Shinooka, A Hasegawa, T Kichise, T Yamashita, H Yoshizawa, R Watanabe, TA Matsuyama, H Ishibashi-, S Koba, Y Kobayashi, T Hirano, T Watanabe Potent Vasoconstrictor Kisspeptin-10 Induces Atherosclerotic Plaque Progression and Instability: Reversal by its Receptor GPR54 Antagonist J Am Heart Assoc, 2017-04-14;6(4):. 2017-04-14 [PMID: 28411243] (Western Blot, Human)	Western Blot	Human
Kensuke Mitsunari, Yasuyoshi Miyata, Shin-Ichi Watanabe, Akihiro Asai, Takuji Yasuda, Shigeru Kanda et al. Stromal expression of Fer suppresses tumor progression in renal cell carcinoma and is a predictor of survival Oncology Letters 2/1/2017 [PMID: 28356966]
Yuyan Wang, Tyler Gable, Mark Z. Ma, David Clark, Jun Zhao, Yi Zhang et al. A piRNA-like Small RNA Induces Chemoresistance to Cisplatin-Based Therapy by Inhibiting Apoptosis in Lung Squamous Cell Carcinoma Molecular Therapy - Nucleic Acids 3/17/2017 [PMID: 28325293]
J Deshmukh, R Pofahl, I Haase Epidermal Rac1 regulates the DNA damage response and protects from UV-light-induced keratinocyte apoptosis and skin carcinogenesis Cell Death Dis, 2017-03-09;8(3):e2664. 3/9/2017 [PMID: 28277539]
C Andreani, C Bartolacci, K Wijnant, R Crinelli, M Bianchi, M Magnani, A Hysi, M Iezzi, A Amici, C Marchini Resveratrol fuels HER2 and ER?-positive breast cancer behaving as proteasome inhibitor Aging (Albany NY), 2017-02-26;9(2):508-523. 2017-02-26 [PMID: 28238967] (IHC, Mouse)	IHC	Mouse
X Wang, GX Xue, WC Liu, H Shu, M Wang, Y Sun, X Liu, YE Sun, CF Liu, J Liu, W Liu, X Jin Melatonin alleviates lipopolysaccharide-compromised integrity of blood-brain barrier through activating AMP-activated protein kinase in old mice Aging Cell, 2017-02-03;0(0):. 2017-02-03 [PMID: 28156052] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Lucian Beer Ionizing radiation regulates long non-coding RNAs in human peripheral blood mononuclear cells J. Radiat. Res, 2017-03-01;0(0):. 2017-03-01 [PMID: 27974506] (Western Blot, Human)	Western Blot	Human
H-Ras and K-Ras oncoproteins induce different tumor spectra when driven by the same regulatory sequences Cancer Res., 2016-11-21;0(0):. 2016-11-21 [PMID: 27872088] (IHC-P, Mouse)	IHC-P	Mouse
Elaine Fuchs Impaired Epidermal to Dendritic T Cell Signaling Slows Wound Repair in Aged Skin Cell, 2016-11-17;167(5):1323-1338.e14. 2016-11-17 [PMID: 27863246] (IHC, Mouse)	IHC	Mouse
Chimeric Mice with Competent Hematopoietic Immunity Reproduce Key Features of Severe Lassa Fever PLoS Pathog, 2016-05-18;12(5):e1005656. 2016-05-18 [PMID: 27191716] (IHC-P, Mouse)	IHC-P	Mouse
Aditi Banerjee, Hafiz Ahmed, Peixin Yang, Steven J. Czinn, Thomas G. Blanchard Endoplasmic reticulum stress and IRE-1 signaling cause apoptosis in colon cancer cells in response to andrographolide treatment Oncotarget 7/5/2106 [PMID: 27166181]
Tania L Slatter Antitumor cytotoxicity induced by bone-marrow-derived antigen-presenting cells is facilitated by the tumor suppressor protein p53 via regulation of IL-12 Oncoimmunology, 2015-12-17;5(3):e1112941. 2015-12-17 [PMID: 27141366] (IHC, Mouse)	IHC	Mouse
KAROLINA WOJTOWICZ, RADOSŁAW JANUCHOWSKI, PATRYCJA SOSIŃSKA, MICHAŁ NOWICKI, MACIEJ ZABEL Effect of brefeldin A and castanospermine on resistant cell lines as supplements in anticancer therapy Oncology Reports 5/1/2016 [PMID: 26985570]
Anne M. Noonan, Kristen P. Bunch, Jin-Qiu Chen, Michelle A. Herrmann, Jung-Min Lee, Elise C. Kohn et al. Pharmacodynamic markers and clinical results from the phase 2 study of the SMAC mimetic birinapant in women with relapsed platinum-resistant or -refractory epithelial ovarian cancer Cancer 2/15/2016 [PMID: 26566079]
Anna Cariboni, Valentina André, Sophie Chauvet, Daniele Cassatella, Kathryn Davidson, Alessia Caramello et al. Dysfunctional SEMA3E signaling underlies gonadotropin-releasing hormone neuron deficiency in Kallmann syndrome Journal of Clinical Investigation 6/1/2015 [PMID: 25985275]
Himmelein S, Lindemann A, Sinicina I, Strupp M, Brandt T, Hufner K Latent herpes simplex virus 1 infection does not induce apoptosis in human trigeminal Ganglia. J Virol, 2015-03-11;89(10):5747-50. 2015-03-11 [PMID: 25762734] (IHC-Fr, Human)	IHC-Fr	Human
Prevete N, Liotti F, Visciano C, Marone G, Melillo R, de Paulis A The formyl peptide receptor 1 exerts a tumor suppressor function in human gastric cancer by inhibiting angiogenesis. Oncogene, 2014-09-29;34(29):3826-38. 2014-09-29 [PMID: 25263443] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Diefenbacher M, Popov N, Blake S, Schulein-Volk C, Nye E, Spencer-Dene B, Jaenicke L, Eilers M, Behrens A The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer. J Clin Invest, 2014-06-24;124(8):3407-18. 2014-06-24 [PMID: 24960159] (IHC, Mouse)	IHC	Mouse
Yuan , Dongqing, Xu , Yidan, Hang , Hui, Liu , Xiaoyi, Chen , Xi, Xie , Ping, Yuan , Songtao, Zhang , Weiwei, Lin , Xiaojun, Liu , Qinghuai Edaravone protect against retinal damage in streptozotocin-induced diabetic mice. PLoS ONE, 2014-06-04;9(6):e99219. 2014-06-04 [PMID: 24897298] (Western Blot, Mouse)	Western Blot	Mouse
Wiener Z, Band A, Kallio P, Hogstrom J, Hyvonen V, Kaijalainen S, Ritvos O, Haglund C, Kruuna O, Robine S, Louvard D, Ben-Neriah Y, Alitalo K Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-beta. Proc Natl Acad Sci U S A, 2014-05-13;111(21):E2229-36. 2014-05-13 [PMID: 24825889] (Western Blot, Human, Mouse)	Western Blot	Human, Mouse
Oestereich L, Rieger T, Neumann M, Bernreuther C, Lehmann M, Krasemann S, Wurr S, Emmerich P, de Lamballerie X, Olschlager S, Gunther S Evaluation of antiviral efficacy of ribavirin, arbidol, and T-705 (favipiravir) in a mouse model for Crimean-Congo hemorrhagic fever. PLoS Negl Trop Dis, 2014-05-01;8(5):e2804. 2014-05-01 [PMID: 24786461] (IHC, Mouse)	IHC	Mouse
Liu L, Salnikov A, Bauer N, Aleksandrowicz E, Labsch S, Nwaeburu C, Mattern J, Gladkich J, Schemmer P, Werner J, Herr I Triptolide reverses hypoxia-induced epithelial-mesenchymal transition and stem-like features in pancreatic cancer by NF-kappaB downregulation. Int J Cancer, 2014-05-15;134(10):2489-503. 2014-05-15 [PMID: 24615157] (IHC-Fr, Human)	IHC-Fr	Human
Hahn W, Kuzmicic J, Burrill J, Donoghue M, Foncea R, Jensen M, Lavandero S, Arriaga E, Bernlohr D Proinflammatory cytokines differentially regulate adipocyte mitochondrial metabolism, oxidative stress, and dynamics. Am J Physiol Endocrinol Metab, 2014-03-04;306(9):E1033-45. 2014-03-04 [PMID: 24595304] (Western Blot, Mouse)	Western Blot	Mouse
Ghulam Mohammad, Mohammad Mairaj Siddiquei, Ahmed M. Abu El-Asrar Poly (ADP-Ribose) Polymerase Mediates Diabetes-Induced Retinal Neuropathy Mediators of Inflammation 11/21/2013 [PMID: 24347828]
Ahmed M. Abu El-Asrar, Mohd Imtiaz Nawaz, Mohammad Mairaj Siddiquei, Abdullah S. Al-Kharashi, Dustan Kangave, Ghulam Mohammad High-Mobility Group Box-1 Induces Decreased Brain-Derived Neurotrophic Factor-Mediated Neuroprotection in the Diabetic Retina Mediators of Inflammation 5/20/2013 [PMID: 23766563]
Hage C, Rausch V, Giese N, Giese T, Schonsiegel F, Labsch S, Nwaeburu C, Mattern J, Gladkich J, Herr I The novel c-Met inhibitor cabozantinib overcomes gemcitabine resistance and stem cell signaling in pancreatic cancer. Cell Death Dis, 2013-05-09;4(0):e627. 2013-05-09 [PMID: 23661005] (IHC, Human)	IHC	Human
Janek T, Krasowska A, Radwanska A, Lukaszewicz M Lipopeptide biosurfactant pseudofactin II induced apoptosis of melanoma A 375 cells by specific interaction with the plasma membrane. PLoS ONE, 2013-03-06;8(3):e57991. 2013-03-06 [PMID: 23483962] (IHC, Human)	IHC	Human
Downs I, Liu J, Aw TY, Adegboyega PA, Ajuebor MN The ROS scavenger, NAC, regulates hepatic Vα14iNKT cells signaling during Fas mAb-dependent fulminant liver failure. PLoS ONE, 2012-06-06;7(6):e38051. 2012-06-06 [PMID: 22701598] (Western Blot, Mouse)	Western Blot	Mouse
Goldie S, Mulder K, Tan D, Lyons S, Sims A, Watt F FRMD4A upregulation in human squamous cell carcinoma promotes tumor growth and metastasis and is associated with poor prognosis. Cancer Res, 2012-05-07;72(13):3424-36. 2012-05-07 [PMID: 22564525] (IHC-Fr, Human)	IHC-Fr	Human
Luckhardt Tracy R, Coomes Stephanie M, Trujillo Glenda et al. TLR9-induced interferon beta is associated with protection from gammaherpesvirus-induced exacerbation of lung fibrosis. Fibrogenesis Tissue Repair. 1/1/2011 [PMID: 21810214]
Rong-Yi Chen, Hong-Xiang Chen, Ping Jian, Li Xu, Juan Li, Yi-Ming Fan et al. Intratumoral injection of pEGFC1-IGFBP7 inhibits malignant melanoma growth in C57BL/6J mice by inducing apoptosis and down-regulating VEGF expression Oncology Reports 3/6/2010 [PMID: 20204282]
Chen RY, Chen HX, Lin JX In-vivo transfection of pcDNA3.1-IGFBP7 inhibits melanoma growth in mice through apoptosis induction and VEGF downexpression. J. Exp. Clin. Cancer Res., 2010-02-16;29(0):13. 2010-02-16 [PMID: 20158915] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Han Y, Wu G, Deng J, Tao J, Guo L, Tian X, Kang J, Zhang X, Yan C Cellular repressor of E1A-stimulated genes inhibits human vascular smooth muscle cell apoptosis via blocking P38/JNK MAP kinase activation. J. Mol. Cell. Cardiol., 2010-01-06;48(6):1225-35. 2010-01-06 [PMID: 20060003] (IHC-Fr, Western Blot, Human)	IHC-Fr, Western Blot	Human
Deng J, Han Y, Yan C, Tian X, Tao J, Kang J, Li S Overexpressing cellular repressor of E1A-stimulated genes protects mesenchymal stem cells against hypoxia- and serum deprivation-induced apoptosis by activation of PI3K/Akt. Apoptosis, 2010-04-01;15(4):463-73. 2010-04-01 [PMID: 19997978] (Western Blot, Rat)	Western Blot	Rat
Terayama R, Bando Y, Murakami K, Kato K, Kishibe M, Yoshida S Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury. Neuroscience, 2007-07-12;148(1):175-87. 2007-07-12 [PMID: 17629414] (Western Blot, Mouse)	Western Blot	Mouse
Olivotto E, Vitellozzi R, Fernandez P, Falcieri E, Battistelli M, Burattini S, Flamigni F, Santi S, Borzi RM Chondrocyte hypertrophy and apoptosis induced by GROalpha require three-dimensional interaction with the extracellular matrix and a co-receptor role of chondroitin sulfate and are associated with the mitochondrial splicing variant of cathepsin B. J. Cell. Physiol., 2007-02-01;210(2):417-27. 2007-02-01 [PMID: 17096385] (IHC, Human)	IHC	Human
Raz V, Carlotti F, Vermolen BJ, van der Poel E, Sloos WC, Knaan-Shanzer S, de Vries AA, Hoeben RC, Young IT, Tanke HJ, Garini Y, Dirks RW Changes in lamina structure are followed by spatial reorganization of heterochromatic regions in caspase-8-activated human mesenchymal stem cells. J. Cell. Sci., 2006-09-26;119(0):4247-56. 2006-09-26 [PMID: 17003109] (ICC, Human)	ICC	Human
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Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	WB	Human	02/25/2015	View Summary Application Western Blot Sample Tested See PMID 22160308 Species Human
	5 reviewed by: Verified Customer	IF	Human	02/25/2015	View Summary Application Immunofluorescence Sample Tested See PMID 23483962 Species Human
	4 reviewed by: Verified Customer	WB	Human	02/25/2015	View Summary Application Western Blot Sample Tested See PMID 23536519 Species Human
	4 reviewed by: Verified Customer	IHC-P	Mouse	02/25/2015	View Summary Application Immunohistochemistry-Paraffin Sample Tested See PMID 23637762 Species Mouse

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