beta-Defensin 4/2 Antibody

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human BD-2, also known as defensin beta 2 (DEFB-2), is a secreted, 41 amino acid residue anti-microbial protein belonging to the defensin family. Mature defensins are cationic proteins with three intramolecular disulfides and a characteristic triple-stranded beta -sheet. Human BD-2 expression is induced by inflammatory signals in multiple tissues, including airway epithelial cells and keratinocytes. At the amino acid sequence level, human BD-2 shares 98% and 51% homology with the proteins from rhesus monkey and rat, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IHC-P.

Showing Publications 1 - 6 of 6.

Publications using AF2758	Applications	Species
Ulvi K. Gürsoy, Krista Salli, Eva Söderling, Mervi Gürsoy, Johanna Hirvonen, Arthur C. Ouwehand Regulation of hBD-2, hBD-3, hCAP18/LL37, and Proinflammatory Cytokine Secretion by Human Milk Oligosaccharides in an Organotypic Oral Mucosal Model Pathogens 6/11/2021 [PMID: 34208335]
Meltem Özdemir, Feriha Caglayan, Floris J. Bikker, Pirkko Pussinen, Eija Könönen, Nermin Yamalik et al. Gingival tissue human beta‐defensin levels in relation to infection and inflammation Journal of Clinical Periodontology 3/1/2020 [PMID: 31799742]
E Vartina, M Pilmane, R Lacis Inflammatory cytokines and antimicrobial peptides in acquired heart diseases Histol. Histopathol., 2019-02-08;0(0):18091. 2019-02-08 [PMID: 30734265] (IHC-P, Human)	IHC-P	Human
Haisma E, Rietveld M, de Breij A, van Dissel J, El Ghalbzouri A, Nibbering P Inflammatory and antimicrobial responses to methicillin-resistant Staphylococcus aureus in an in vitro wound infection model. PLoS ONE, 2013-12-10;8(12):e82800. 2013-12-10 [PMID: 24340061] (IHC-P, Human)	IHC-P	Human
Gursoy UK, Pollanen M, Kononen E, Uitto VJ A Novel Organotypic Dento-Epithelial Culture Model: Effect of Fusobacterium nucleatum Biofilm on B-Defensin-2, -3, and LL-37 Expression. J. Periodontol., 2011-06-21;83(2):242-7. 2011-06-21 [PMID: 21692631] (IHC-P, Human)	IHC-P	Human
Birgit Riepl, Susanne Grässel, Reiner Wiest, Martin Fleck, Rainer H Straub Tumor necrosis factor and norepinephrine lower the levels of human neutrophil peptides 1-3 secretion by mixed synovial tissue cultures in osteoarthritis and rheumatoid arthritis Arthritis Research & Therapy 6/4/2010 [PMID: 20525314]

Array AF2758

• beta-Defensin 4/2 Antibodies
• beta-Defensin 4/2 ELISA Kits
• beta-Defensin 4/2 Proteins