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beta-Arrestin 1 Antibody

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Immunohistochemistry: beta-Arrestin 1 Antibody [NBP2-68897] - Immunohistochemical staining of human cerebral cortex shows moderate cytoplasmic and nuclear positivity in neuronal cells.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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beta-Arrestin 1 Antibody Summary

Immunogen
This antibody was developed against a recombinant protein corresponding to amino acids: LKGMKDDKEEEEDGTGSPQLNNR
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ARRB1
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200 - 1:500
Application Notes
Recommended conditions for IHC,Retrieval method: HIER pH6
Control Peptide
beta-Arrestin 1 Recombinant Protein Antigen (NBP2-68897PEP)

Reactivity Notes

Mouse 87%, Rat 87%

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Protein A purified

Alternate Names for beta-Arrestin 1 Antibody

  • ARB1
  • ARR1
  • ARRB1
  • arrestin 2
  • Arrestin beta-1
  • arrestin, beta 1
  • betaArrestin 1
  • beta-Arrestin 1
  • beta-arrestin-1

Background

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization ofG-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones,neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in thebeta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the centralnervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin systemis believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcriptsencoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known.(provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol ARRB1