B7-1/CD80 Antibody (37711) [Phycoerythrin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down‑regulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B7-2 is expressed at low levels on monocytes and can be up-regulated through interferon gamma . B7-1 and B7-2 are both members of the Immunoglobulin superfamily. Human B7-1 is a 288 amino acid (aa) protein containing a 34 aa signal peptide, a 208 aa extracellular domain, a 21 aa transmembrane domain, and a 25 aa cytoplasmic domain. Human B7-1 and B7-2 share 26% aa sequence identity. Human and mouse B7-1 share 44% aa sequence identity. However, it has been observed that both human and mouse B7-1 and B7-2 can bind to either human or mouse CD28 and CTLA-4, suggesting that there are conserved amino acids which form the B7-1/B7-2/CD28/CTLA-4 critical binding sites.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Porcine.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 6 of 6.

Publications using FAB140P	Applications	Species
L Hyväri, M Ojansivu, M Juntunen, K Kartasalo, S Miettinen, S Vanhatupa Focal Adhesion Kinase and ROCK Signaling Are Switch-Like Regulators of Human Adipose Stem Cell Differentiation towards Osteogenic and Adipogenic Lineages Stem Cells Int, 2018-09-12;2018(0):2190657. 2018-09-12 [PMID: 30275837] (Flow Cytometry, Human)	Flow Cytometry	Human
M Ojansivu, A Mishra, S Vanhatupa, M Juntunen, A Larionova, J Massera, S Miettinen The effect of S53P4-based borosilicate glasses and glass dissolution products on the osteogenic commitment of human adipose stem cells PLoS ONE, 2018-08-28;13(8):e0202740. 2018-08-28 [PMID: 30153295] (Flow Cytometry, Human)	Flow Cytometry	Human
Qu X, Proll M, Neuhoff C, Zhang R, Cinar M, Hossain M, Tesfaye D, Grosse-Brinkhaus C, Salilew-Wondim D, Tholen E, Looft C, Holker M, Schellander K, Uddin M Sulforaphane epigenetically regulates innate immune responses of porcine monocyte-derived dendritic cells induced with lipopolysaccharide. PLoS ONE, 2015-03-20;10(3):e0121574. 2015-03-20 [PMID: 25793534] (Flow Cytometry, Porcine)	Flow Cytometry	Porcine
Herova M, Schmid M, Gemperle C, Hersberger M ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages. J Immunol, 2015-01-30;194(5):2330-7. 2015-01-30 [PMID: 25637017] (Flow Cytometry, Human)	Flow Cytometry	Human
El Fakhry Y, Alturaihi H, Diallo D, Merhi Y, Mourad W Critical role of lipid rafts in CD154-mediated T cell signaling. Eur. J. Immunol., 2010-03-01;40(3):770-9. 2010-03-01 [PMID: 20039299] (Flow Cytometry, Human)	Flow Cytometry	Human
Lotfi R, Lotze MT Eosinophils induce DC maturation, regulating immunity. J. Leukoc. Biol., 2007-11-08;83(3):456-60. 2007-11-08 [PMID: 17991762] (Flow Cytometry, Human)	Flow Cytometry	Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	3 reviewed by: Verified Customer	Flow	Human	03/01/2019	View Summary Application Flow Cytometry Sample Tested Human PBMC Species Human Lot LCR0316031 Comments Comments Human PBMCs were stained with anti-human CD80 PE.

Array FAB140P

• B7-1/CD80 Antibodies
• B7-1/CD80 ELISA Kit
• B7-1/CD80 Proteins
• B7-1/CD80 Proteins and Enzymes
• B7-1/CD80 ELISAs