CD80 is a 60kD single chain type I transmembrane glycoprotein that is a member of the immunoglobulin family. CD80 is expressed on activated B- and T-lymphocytes, as well as a subpopulation of previously activated B-cells, but not on the majority of resting B-cells in peripheral blood. It is also found constitutively expressed on dendritic cells and macrophages. CD80 and CD86 are both ligands for two structurally similar molecules expressed on T-lymphocytes - CD28 and CTLA4/CD152. Binding to these molecules is a potent co-stimulatory CD3 complex-dependent signal for T-lymphocyte activation, cytokinse production, and T-cell tolerance establishment. The roles of co-stimulatory (CD28) and co-inhibitory (CTLA4) molecules in T-cell receptor (TCR) signaling are nicely published by Chen in a Nature Reviews in Immunology1. Additionally, Soskic et al dedicates a chapter to discussing recent molecular and cellular concepts of this dual system as it relates specifically to transendocytosis and a novel aspect of CTLA4 function2. Romo-Tena also reviews the role of CTLA4 as it pertains to autoimmune diseases such as systemic lupus erythematosus (SLE) and shares some important insights into future safety and efficacy3.
Novus Biologicals offers CD80 reagents for your research needs including:
PMIDs
