Aurora A [p Thr288] Antibody

The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 5 confirmed species: Human, Mouse, Bovine, Porcine, Sheep.

We have publications tested in 2 applications: ICC/IF, IF/IHC.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using NB100-2371	Applications	Species
Wang X, Baumann C, De La Fuente R, Viveiros MM Loss of acentriolar MTOCs disrupts spindle pole Aurora A and assembly of the liquid-like meiotic spindle domain in oocytes Journal of cell science 2021-07-15 [PMID: 34152366]
Kovarikova V, Burkus J, Rehak P et al. Aurora kinase A is essential for correct chromosome segregation in mouse zygote. Zygote 2015-07-15 [PMID: 26174602] (Mouse)		Mouse
Solc P, Baran V, Mayer A et al. Aurora Kinase A Drives MTOC Biogenesis but Does Not Trigger Resumption of Meiosis in Mouse Oocytes Matured In Vivo Biol Reprod 2012-10-01 [PMID: 22837479]
Saskova A, Solc P, Baran V et al. Aurora kinase A controls meiosis I progression in mouse oocytes. Cell Cycle 2008-08-01 [PMID: 18677115]
Thomas A, Meraldi P Centrosome age breaks spindle size symmetry even in “symmetrically” dividing cells bioRxiv 2023-09-15 (ICC/IF, Human)	ICC/IF	Human
Yoshida S, Nishiyama S, Lister L et al. Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes Nat Commun 2020-05-27 [PMID: 32461611] (Human)		Human
So C, Seres K. B, et al. A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes. Science 2019-06-28 [PMID: 31249032] (ICC/IF, Sheep, Mouse, Bovine, Porcine)	ICC/IF	Sheep, Mouse, Bovine, Porcine
Vallot A, Leontiou I, Cladiere D et al. Tension-Induced Error Correction and Not Kinetochore Attachment Status Activates the SAC in an Aurora-B/C-Dependent Manner in Oocytes Curr. Biol. 2018-01-08 [PMID: 29276128] (ICC/IF)	ICC/IF
Komrskova P, Susor A, Malik R et al. Aurora Kinase A Is Not Involved in CPEB1 Phosphorylation and cyclin B1 mRNA Polyadenylation during Meiotic Maturation of Porcine Oocytes. PLoS ONE 2014-07-02 [PMID: 24983972] (ICC/IF, Porcine) Details: Aurora A [p Thr288] antibody used for ICC-IF on Porcine oocytes isolated from ovaries from non-cycling gilts. Oocytes fixed in 4% PFA-PBS for 30 min, permeabilized in 0.1% Triton X-100 for 15 min, incubated with primary ON 4C followed by detection using Alexa Fluor conjugated anti-rabbit antibody (Figure 3).	ICC/IF	Porcine
Baran V, Solc P, Kovarikova V et al. Polo-like kinase 1 is essential for the first mitotic division in the mouse embryo. Mol Reprod Dev 2013-05-06 [PMID: 23649868] (IF/IHC, ICC/IF, Mouse)	IF/IHC, ICC/IF	Mouse
Plotnikova OV, Pugacheva EN, Golemis EA et al. Aurora A kinase activity influences calcium signaling in kidney cells. J Cell Biol 2011-06-01 [PMID: 21670214]
Show All 11 Publications. Collapse Publications.

Array NB100-2371

• Aurora A Antibodies
• Aurora A Lysates
• Aurora A Proteins