ASCL2/Mash2 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

ASCL2 (Achaete-scute like 2; also HASH2, bHLHa45 and Mash2) is a class II member of the HLH family of transcription factors. Its predicted MW is 20 kDa. ASCL2 shows restricted expression, being limited to intestinal Lgr5⁺ stem cells and first trimester placental cytotrophoblasts. In the intestine, ASCL2 is under the control of Wnts and serves to maintain an epithelium stem cell pool. In the placenta, ASCL2 acts to maintain the pool of cytotrophoblasts at the expense of synctiotrophoblasts, thus promoting placental growth. Human ASCL2 is 193 amino acids (aa) in length. It contains one poly-Arg motif (aa 36-39), a DNA binding sequence (aa 53-63) and an HLH domain (aa 64-103). ASCL2 forms heterodimers with daughterless homologs (E22, E2A and HEB). Over aa 1-49, human ASCL2 shares 59% aa identity with mouse Mash2.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 3 of 3.

Publications using AF6539	Applications	Species
Enqi Zheng, Zhun Cai, Wangyong Li, Chuandou Ni, Qian Fang Achaete-scute complex-like 2 regulated inflammatory mechanism through Toll-like receptor 4 activating in stomach adenocarcinoma World Journal of Surgical Oncology 2022-08-25 [PMID: 36008864]
Yukiko Shibahara, Osvaldo Espin-Garcia, James Conner, Jessica Weiss, Mathieu Derouet, Jonathan Allen et al. Intestinal Stem Cell Marker ASCL2 is a Novel Prognostic Predictor in Esophageal Adenocarcinoma Cureus 2022-01-07 [PMID: 35154991]
Renaud S, Chakraborty D, Mason C, Rumi M, Vivian J, Soares M OVO-like 1 regulates progenitor cell fate in human trophoblast development. Proc Natl Acad Sci U S A, 2015-10-26;112(45):E6175-84. 2015-10-26 [PMID: 26504231]

Array AF6539

• ASCL2/Mash2 Antibodies