ASC2 Antibody

ASC-2/POP1 is a PAAD domain only protein originally identified in a bioinformatics screen aimed at understanding molecular apoptosis mechanisms (Pawtokski et al, 2001; reviewed in Fabiola et al, 2006, and Mariathasan and Vuvic, 2003.). ASC-2/POP1 has high amino acid sequence homology with ASC (64%), hence it was originally termed ASC-2. The PAAD (also known as PYRIN) domain is a conserved sequence motif identified in more than 35 human proteins with putative functions in apoptosis and inflammatory signaling pathways. PAAD was named after the protein families from which it was discovered: pyrin, AIM (absent-in-melanoma), ASC [apoptosis-associated speck-like protein containing a caspase recruitment domain (CARD], and death-domain (DD)-like. PAAD is thought to function as a protein-protein interaction domain, possibly coupling different signaling pathways such as apoptosis, inflammation and cancer. For example, PAADs are capable of homotypic interactions with themselves or other members of the PAAD family, suggesting that they participate in complex protein-interaction networks that link various signaling pathways. In humans, the gene encoding ASC-2/POP1 is on chromosome 16p12.1, only 14 kbp away from the ASC locus. The proximity of ASC-2/POP1 to ASC as well as the high sequence homology between them suggest that the ASC-2/POP1 and ASC genes arose by gene duplication. Studies have shown that ASC-2/POP1 associates with ASC via PAAD-PAAD interactions and modulates ASC-mediated roles in apoptosis and inflammation. ASC-2/POP1 may also have a role in modulating other multidomain PAAD-containing proteins. However, the physiological relevance of ASC-2/POP1 remains to be fully elucidated. Human ASC-2/POP1 is an 89 amino acid protein and migrates at ~10-12 kDa on SDS-PAGE gels (Stehlik et al, 2003).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 application: WB.

Showing Publications 1 - 2 of 2.

Publications using NB100-56076	Applications	Species
Cai R, Xu Y, Ren Y et al. MicroRNA-136-5p protects cardiomyocytes from coronary microembolization through the inhibition of pyroptosis Apoptosis : an international journal on programmed cell death 2022-01-27 [PMID: 35084609]
Stehlik C, Krajewska M, Welsh K et al. The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation. Biochem J. 2003-07-01 [PMID: 12656673] (WB)	WB

Array NB100-56076

• ASC2 Antibodies
• ASC2 Lysate
• ASC2 Protein