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Ankyrin 1 Antibody (S388A-60) [DyLight 488]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications ICC/IF, IHC
Clone
S388A-60
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 488

Ankyrin 1 Antibody (S388A-60) [DyLight 488] Summary

Immunogen
Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R
Localization
Cytoplasm , Cytoskeleton , Myofibril , Sarcomere , M line
Specificity
Detects 200kDa. Cross-reacts with Ankyrin-B and Ankyrin-G.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ANK1
Purity
Protein G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Alternate Names for Ankyrin 1 Antibody (S388A-60) [DyLight 488]

  • ANK
  • ANK-1
  • ankyrin 1, erythrocytic
  • ankyrin-1
  • ankyrin-R
  • Erythrocyte ankyrin
  • SPH1
  • SPH2

Background

Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actincytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and themaintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various targetproteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed ofthree structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highlyconserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subjectto variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has alsobeen found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of allpatients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving riseto different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting fromusage of an alternate promoter have also been identified. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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ICC/IF Video Protocol

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Bioinformatics

Gene Symbol ANK1