ADAMTS1 Antibody

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

ADAMTS1 (a disintegrin and metalloproteinase with thrombospondin motifs 1), also known as METH1, is the founding member of the family of secreted zinc proteases with a multidomain structure (1-3). The protein precursor consists of a signal peptide and the following domains: pro, catalytic, disintegrinlike, TS type 1 motif, cysteine rich, spacer and a variable number of thrombospondin type 1 motifs. Based on their substrate specificity, ADAMTS1 and associated family members may be key enzymes in the degradation of cartilage leading to inflammation and arthritis (4). It is an active protease cleaving alpha 2macroglobulin (5), aggrecan (6), and versican (7). Compared to ADAMTS4 (aggrecanase 1) and ADAMTS5 (aggrecanase 2), the aggrecanase activity of ADAMTS1 is lower. However, its activity can be enhanced by the binding of a cofactor such as fibulin1 (8). ADAMTS1 is essential for normal growth and the structure and function of the kidneys, adrenal glands and female reproductive organs (9). It also plays an important role in atherosclerosis (10). It has been shown to inhibit endothelial cell proliferation by direct binding and sequestration of VEGF165 and to inhibit fibroblast migration at high concentrations by binding to FGF 2 (11, 12). The purified rmADAMTS1 starts at the N terminus of the catalytic domain and ends in the Cys-rich domain.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: IHC, Western Blot.

Showing Publications 1 - 10 of 10.

Publications using AF5867	Applications	Species
Sophie Schmidt, Max Holzer, Thomas Arendt, Mandy Sonntag, Markus Morawski Tau Protein Modulates Perineuronal Extracellular Matrix Expression in the TauP301L-acan Mouse Model Biomolecules 2022-03-26 [PMID: 35454094]
Thashi Bharadwaj, Isabelle Schrauwen, Sakina Rehman, Khurram Liaqat, Anushree Acharya, Arnaud P. J. Giese et al. ADAMTS1, MPDZ, MVD, and SEZ6: candidate genes for autosomal recessive nonsyndromic hearing impairment European Journal of Human Genetics 1/1/2022 [PMID: 34135477]
SY Cheung, M Sayeed, K Nakuluri, L Li, BJ Feldman MYH9 facilitates autoregulation of adipose tissue depot development JCI Insight, 2021-05-10;6(9):. 2021-05-10 [PMID: 33986190] (Western Blot, Mouse)	Western Blot	Mouse
O Serrano-Ga, C Peris-Torr, S Redondo-Ga, HG Asenjo, MDC Plaza-Calo, JL Fernandez-, JC Rodríguez- ADAMTS1 Supports Endothelial Plasticity of Glioblastoma Cells with Relevance for Glioma Progression Biomolecules, 2020-12-31;11(1):. 2020-12-31 [PMID: 33396280] (Human)		Human
C Peris-Torr, MDC Plaza-Calo, R López-Domí, S Domínguez-, A Barrientos, P Carmona-Sá, JC Rodríguez- Extracellular Protease ADAMTS1 Is Required at Early Stages of Human Uveal Melanoma Development by Inducing Stemness and Endothelial-Like Features on Tumor Cells Cancers (Basel), 2020-03-27;12(4):. 2020-03-27 [PMID: 32230715] (Western Blot, Human)	Western Blot	Human
E Vorkapic, M Folkesson, K Magnell, M Bohlooly-Y, T Länne, D Wågsäter ADAMTS-1 in abdominal aortic aneurysm PLoS ONE, 2017-06-01;12(6):e0178729. 2017-06-01 [PMID: 28570682] (IHC, Western Blot, Human)	IHC, Western Blot	Human
Wong J, Krueger K, Costa M, Aggarwal A, Du H, McLaughlin T, Feldman B A glucocorticoid- and diet-responsive pathway toggles adipocyte precursor cell activity in vivo. Sci Signal, 2016-10-25;9(451):ra103. 2016-10-25 [PMID: 27811141] (Western Blot, Mouse)	Western Blot	Mouse
Rubén Fernández-Rodríguez, Francisco Javier Rodríguez-Baena, Estefanía Martino-Echarri, Carlos Peris-Torres, María del Carmen Plaza-Calonge, Juan Carlos Rodríguez-Manzaneque Stroma-derived but not tumor ADAMTS1 is a main driver of tumor growth and metastasis Oncotarget 2016-06-07 [PMID: 27120788]
Tian , E, Stevens , Sharon R, Guan , Yu, Springer , Danielle, Anderson , Stasia A, Starost , Matthew, Patel , Vyomesh, Ten Hagen , Kelly G, Tabak , Lawrence Galnt1 is required for normal heart valve development and cardiac function. PLoS ONE, 2015-01-23;10(1):e0115861. 2015-01-23 [PMID: 25615642] (IHC, Mouse)	IHC	Mouse
Inagaki J, Takahashi K, Ogawa H, Asano K, Faruk Hatipoglu O, Cilek M, Obika M, Ohtsuki T, Hofmann M, Kusachi S, Ninomiya Y, Hirohata S ADAMTS1 inhibits lymphangiogenesis by attenuating phosphorylation of the lymphatic endothelial cell-specific VEGF receptor. Exp Cell Res, 2014-03-11;323(2):263-75. 2014-03-11 [PMID: 24631293] (Western Blot, Human)	Western Blot	Human

Array AF5867

• ADAMTS1 Antibodies
• ADAMTS1 Lysate
• ADAMTS1 Proteins and Enzymes
• ADAMTS1 ELISA