Activin A Antibody (69403) - beta A subunit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Activin and Inhibin are members of the TGF-beta superfamily of cytokines and are involved in a wide range of biological processes including tissue morphogenesis and repair, fibrosis, inflammation, neural development, hematopoiesis, reproductive system function, and carcinogenesis (1‑7). Activin and Inhibin are produced as precursor proteins. Their amino terminal propeptides are proteolytically cleaved and facilitate formation of disulfide-linked dimers of the bioactive proteins (8, 9). Activins are nonglycosylated homodimers or heterodimers of various beta  subunits ( beta A, beta B, beta C, and beta E in mammals), while Inhibins are heterodimers of a unique alpha  subunit and one of the beta  subunits. Activin A is a widely expressed homodimer of two beta A chains. The beta A subunit can also heterodimerize with a beta B or beta C subunit to form Activin AB and Activin AC, respectively (10). The 14 kDa mature human beta A chain shares 100% amino acid sequence identity with bovine, feline, mouse, porcine, and rat beta A. Activin A exerts its biological activities by binding to the type 2 serine/threonine kinase Activin RIIA which then noncovalently associates with the type 1 serine/threonine kinase Activin RIB/ALK-4 (7, 11). Signaling through this receptor complex leads to Smad activation and regulation of activin-responsive gene transcription (7, 11). The bioactivity of Activin A is regulated by a variety of mechanisms (11). BAMBI, Betaglycan, and Cripto are cell-associated molecules that function as decoy receptors or limit the ability of Activin A to induce receptor complex assembly (12‑14). The intracellular formation of Activin A can be prevented by the incorporation of the beta A subunit into Activin AC or Inhibin A (3, 10). And the bioavailability of Activin A is restricted by its incorporation into inactive complexes with alpha 2-Macroglobulin, Follistatin, and FLRG (15, 16).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Porcine.

We have publications tested in 8 applications: Bioassay, Blocking, ELISA Development, ICC, IHC, In Vivo, Neutralization, Western Blot.

Showing Publications 1 - 10 of 23. Show All 23 Publications. Collapse Publications.

Publications using MAB3381	Applications	Species
Hrncir, HR;Bombin, S;Goodloe, B;Hogan, CB;Jadi, O;Gracz, AD; Sox9 links biliary maturation to branching morphogenesis bioRxiv : the preprint server for biology 2024-01-16 [PMID: 38293117] (In Vivo, IHC)	In Vivo, IHC
Culver, A;Hamang, M;Wang, Y;Jiang, H;Yanum, J;White, E;Gawrieh, S;Vuppalanchi, RK;Chalasani, NP;Dai, G;Yaden, BC; GDF8 Contributes to Liver Fibrogenesis and Concomitant Skeletal Muscle Wasting Biomedicines 2023-07-06 [PMID: 37509548] (In Vivo, Mouse)	In Vivo	Mouse
Yan Wang, Matthew Hamang, Alexander Culver, Huaizhou Jiang, Jennifer Yanum, Veronica Garcia et al. Activin B promotes the initiation and progression of liver fibrosis Hepatology Communications 10/1/2022 [PMID: 35866567]
Y Zhu, LGPL Prata, EOW Gerdes, JME Netto, T Pirtskhala, N Giorgadze, U Tripathi, CL Inman, KO Johnson, A Xue, AK Palmer, T Chen, K Schaefer, JN Justice, AM Nambiar, N Musi, SB Kritchevsk, J Chen, S Khosla, D Jurk, MJ Schafer, T Tchkonia, JL Kirkland Orally-active, clinically-translatable senolytics restore alpha-Klotho in mice and humans EBioMedicine, 2022-03-13;0(0):103912. 2022-03-13 [PMID: 35292270] (Neutralization, Human)	Neutralization	Human
G Mancinelli, C Torres, N Krett, J Bauer, K Castellano, R McKinney, D Dawson, G Guzman, R Hwang, S Grimaldo, P Grippo, B Jung Role of stromal activin A in human pancreatic cancer and metastasis in mice Scientific Reports, 2021-04-12;11(1):7986. 2021-04-12 [PMID: 33846512] (ICC, Neutralization, Human)	ICC, Neutralization	Human
Qingsu Cheng, Kosar Jabbari, Garrett Winkelmaier, Cody Andersen, Paul Yaswen, Mina Khoshdeli et al. Overexpression of CD36 in mammary fibroblasts suppresses colony growth in breast cancer cell lines Biochemical and Biophysical Research Communications 5/1/2020 [PMID: 32192771]
Kristine Pettersen, Sonja Andersen, Anna van der Veen, Unni Nonstad, Shinji Hatakeyama, Christian Lambert et al. Autocrine activin A signalling in ovarian cancer cells regulates secretion of interleukin 6, autophagy, and cachexia Journal of Cachexia, Sarcopenia and Muscle 2/1/2020 [PMID: 31436048]
Zhenzhen Zhang, Jing Wang, Yabing Chen, Luxuan Suo, Huixian Chen, Li Zhu et al. Activin a promotes myofibroblast differentiation of endometrial mesenchymal stem cells via STAT3-dependent Smad/CTGF pathway Cell Communication and Signaling 12/1/2019 [PMID: 31101053]
Concha Nieto, Rafael Bragado, Cristina Municio, Elena Sierra-Filardi, Bárbara Alonso, María M. Escribese et al. The Activin A-Peroxisome Proliferator-Activated Receptor Gamma Axis Contributes to the Transcriptome of GM-CSF-Conditioned Human Macrophages Frontiers in Immunology 1/29/2018 [PMID: 29434585]
N Spottiswoo, AE Armitage, AR Williams, AJ Fyfe, S Biswas, SH Hodgson, D Llewellyn, P Choudhary, SJ Draper, P Duffy, H Drakesmith The role of activins in hepcidin regulation during malaria Infect. Immun., 2017-11-17;0(0):. 11/17/2017 [PMID: 28893916]
Activin A programs the differentiation of human TFH cells Nat Immunol, 2016-07-04;17(8):976-84. 2016-07-04 [PMID: 27376469] (Bioassay, Human)	Bioassay	Human
Ze-Yang Ding, Guan-Nan Jin, Wei Wang, Yi-Min Sun, Wei-Xun Chen, Lin Chen et al. Activin A-Smad Signaling Mediates Connective Tissue Growth Factor Synthesis in Liver Progenitor Cells International Journal of Molecular Sciences 3/22/2016 [PMID: 27011166]
Ming Xu, Allyson K Palmer, Husheng Ding, Megan M Weivoda, Tamar Pirtskhalava, Thomas A White et al. Targeting senescent cells enhances adipogenesis and metabolic function in old age eLife 12/19/2015 [PMID: 26687007]
Bufalino A, Cervigne N, de Oliveira C, Fonseca F, Rodrigues P, Macedo C, Sobral L, Miguel M, Lopes M, Paes Leme A, Lambert D, Salo T, Kowalski L, Graner E, Coletta R Low miR-143/miR-145 Cluster Levels Induce Activin A Overexpression in Oral Squamous Cell Carcinomas, Which Contributes to Poor Prognosis. PLoS ONE, 2015-08-28;10(8):e0136599. 2015-08-28 [PMID: 26317418] (ELISA Development, Human)	ELISA Development	Human
Merfeld-Clauss S, Lupov I, Lu H, March K, Traktuev D Adipose Stromal Cell Contact with Endothelial Cells Results in Loss of Complementary Vasculogenic Activity Mediated by Induction of Activin A. Stem Cells, 2015-07-03;33(10):3039-51. 2015-07-03 [PMID: 26037810] (Neutralization, Human)	Neutralization	Human
Sierra-Filardi E, Nieto C, Dominguez-Soto A, Barroso R, Sanchez-Mateos P, Puig-Kroger A, Lopez-Bravo M, Joven J, Ardavin C, Rodriguez-Fernandez J, Sanchez-Torres C, Mellado M, Corbi A CCL2 shapes macrophage polarization by GM-CSF and M-CSF: identification of CCL2/CCR2-dependent gene expression profile. J Immunol, 2014-03-17;192(8):3858-67. 2014-03-17 [PMID: 24639350] (Blocking, Human)	Blocking	Human
Xudong Di, Danica M.K. Andrews, Charles J. Tucker, Linda Yu, Alicia B. Moore, Xiaolin Zheng et al. A high concentration of genistein down-regulates activin A, Smad3 and other TGF-beta pathway genes in human uterine leiomyoma cells Experimental & Molecular Medicine 4/30/2012 [PMID: 22228119]
Sierra-Filardi E, Puig-Kroger A, Blanco FJ, Nieto C, Bragado R, Palomero MI, Bernabeu C, Vega MA, Corbi AL Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers. Blood, 2011-03-09;117(19):5092-101. 2011-03-09 [PMID: 21389328] (Neutralization, Human)	Neutralization	Human
Alexander S, Watt F, Sawaji Y, Hermansson M, Saklatvala J Activin A is an anticatabolic autocrine cytokine in articular cartilage whose production is controlled by fibroblast growth factor 2 and NF-kappaB. Arthritis Rheum., 2007-11-01;56(11):3715-25. 2007-11-01 [PMID: 17968943] (Neutralization, Human, Porcine)	Neutralization	Human, Porcine
Kupershmidt L, Amit T, Bar-Am O, Youdim MB, Blumenfeld Z The neuroprotective effect of Activin A and B: implication for neurodegenerative diseases. J. Neurochem., 2007-08-06;103(3):962-71. 2007-08-06 [PMID: 17680997] (Western Blot, Human, Rat)	Western Blot	Human, Rat
Greber B, Lehrach H, Adjaye J Fibroblast growth factor 2 modulates transforming growth factor beta signaling in mouse embryonic fibroblasts and human ESCs (hESCs) to support hESC self-renewal. Stem Cells, 2006-10-12;25(2):455-64. 2006-10-12 [PMID: 17038665] (ELISA Development, Mouse)	ELISA Development	Mouse
Funaba M, Nakaya K, Ikeda T, Murakami M, Tsuchida K, Sugino H Requirement of Smad3 for mast cell growth. Cell. Immunol., 2006-07-12;240(1):47-52. 2006-07-12 [PMID: 16839529] (Neutralization, Western Blot, Mouse)	Neutralization, Western Blot	Mouse
Utsunomiya T, Sonoda H, Mimori K N-cadherin is regulated by activin A and associated with tumor aggressiveness in esophageal carcinoma. Clin. Cancer Res., 2004-09-01;10(17):5702-7. 2004-09-01 [PMID: 15355896] (Western Blot, Human)	Western Blot	Human
Show All 23 Publications. Collapse Publications.

Array MAB3381

• Activin A Antibodies
• Activin A Lysate
• Activin A Protein
• Activin A Proteins and Enzymes
• Activin A ELISAs