Serpin A6/Cortisol Binding Globulin Products

Description

Corticol binding globulin (CBG or transcotin) binds with high affinity to cortisol in plasma. Cortisol is the most potent glucocorticoid produced by the human adrenal. It is synthesized from cholesterol and its production is stimulated by pituitary adrenocorticotropic hormone (ACTH) which is regulated by corticotropin releasing factor (CRF). ACTH and CRF secretions are inhibited by high cortisol levels in a negative feedback loop. Cortisol acts through specific intracellular receptors and affects numerous physiologic systems including immune function, glucose counter regulation, vascular tone, and bone metabolism.

Bioinformatics

Entrez	299270 Rat 866 Human
Uniprot	AAH58021 Human NP_001747 Human NP_001747.2 Human P08185 Human
Product By Gene ID	866
Alternate Names	antitrypsin), member 6 CBGcorticosteroid-binding globulin corticosteroid binding globulin member 6 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase Serpin A6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin) transcortin Transcortin