Recombinant Human Serpin A6 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Corticosteroid-binding globulin (CBG), also known as Serpin A6, is an approximately 42 kDa member of the serpin superfamily of serine protease inhibitors. CBG belongs to the clade A subgroup of serpins which include inflammatory response molecules (1). Human CBG shares 57% sequence identity to mouse CBG. CBG is one of two serpins known to bind and transport hormones. CBG is responsible for binding ~90% of cortisol in a reversible manner to regulate levels under normal physiological states (2). However, cleavage of CBG's reactive site loop by proteases present during an inflammatory response leads to a targeted and immediate release of the anti-inflammatory steroid, cortisol, from CBG (3). Reduced cleavage of CBG is implicated in the inflammatory phenotype seen in obesity, metabolic syndrome, and rheumatoid arthritis (4, 5). Cleavage of CBG can be modulated by glycosylation (6). Naturally occurring mutations of CBG lead to abnormal levels or function (7, 8). Loss of functional CBG results in low cortisol levels in patients experiencing chronic pain, fatigue, hypotension and excess weight (8).

Array 9580-PI

• Serpin A6/Cortisol Binding Globulin Antibodies
• Serpin A6/Cortisol Binding Globulin ELISA Kits
• Serpin A6/Cortisol Binding Globulin Lysate
• Serpin A6/Cortisol Binding Globulin Protein
• Serpin A6/Cortisol Binding Globulin Proteins and Enzyme