PECAM1

Platelet endothelial cell adhesion molecule 1 (PECAM1), also known as cluster of differentiation 31 (CD31), is a cell-surface glycoprotein expressed on platelets, monocytes, neutrophils, some types of T-cells and NK (natural killer) cells. It makes up a large portion of the endothelial cell intercellular junctions. CD31/PECAM1 is a member of the immunoglobulin superfamily and plays many different roles involving leukocyte migration under most inflammatory conditions, angiogenesis, integrin activation, atherosclerosis and thrombopoiesis.

Platelet endothelial cell adhesion molecule, also known as PECAM1 or cluster differentiation 31 (CD31), is an 82 kDa adhesion molecule that is expressed on platelets and leukocytes. Six isoforms are produced by alternative splicing and this protein undergoes post translation modification. PECAM -1 is found on chromosome 17. This protein is concentrated at the borders between endothelial cells.

Platelet Endothelial Cell Adhesion Molecule 1 (PECAM1) is a single-pass membrane receptor also known as CD31 (cluster of differentiation 31.) CD31 is expressed at high levels at endothelial cell junctions, and therefore the CD31 antibody is widely used as an endothelial marker, one use being to measure the progression of angiogenesis following recurrence of tumors.