CD31/PECAM1

Platelet endothelial cell adhesion molecule PECAM1 (also called CD31) is a 130 kDa type I transmembrane glycoprotein that is expressed on most cells of the hematopoietic lineage including platelets, monocytes, neutrophils and certain lymphocyte subsets (1). It has also been suggested that PECAM-1 contributes to endothelial cell barrier function.

Platelet Endothelial Cell Adhesion Molecule 1 (PECAM1), also known as known as CD31 (cluster of differentiation 31), is an Ig supergene family cell adhesion and signaling membrane receptor. CD31/PECAM1 is critical for cell-cell interactions and is expressed on a variety of hematopoetic cells (platelets, granulocytes, monocytes/macrophages, dendritic cells, and T and B cell subsets).

Platelet Endothelial Cell Adhesion Molecule 1 (PECAM1) is a single-pass membrane receptor also known as CD31 (cluster of differentiation 31.) CD31 is expressed at high levels at endothelial cell junctions, and therefore the CD31 antibody is widely used as an endothelial marker, one use being to measure the progression of angiogenesis following recurrence of tumors.