The CD31/PECAM1 Antibody: Have it Your Way

Platelet Endothelial Cell Adhesion Molecule 1 (PECAM1) is a single-pass membrane receptor also known as CD31 (cluster of differentiation 31.) CD31 is expressed at high levels at endothelial cell junctions, and therefore the CD31 antibody is widely used as an endothelial marker, one use being to measure the progression of angiogenesis following recurrence of tumors. Other CD31 antibody studies have suggested a possible use as a myeloid progenitor cell marker, and in the identification of different granular sarcoma subsets.

Novus Biologicals is constantly refining our CD31 antibody catalog to ensure customers have a wide range of reagents to choose from, covering as many assay applications as possible. In addition to standard monoclonals and polyclonals, our catalog also contains a variety of CD31 antibody reagents conjugated to various chromogenic and fluorochromic dyes. Each monoclonal product has a clone identifier in brackets. This identifies which cloned cell line the CD31 antibody was derived from (which may have been established for several years) and is an important factor as different clones can give different results, affecting continuity of research.

A perfect example of this is the CD31 antibody clone TLD-3A12, developed by K.C Williams, et al. in 1996 for rat CNS studies. Novus offers the TLD-3A12 antibody in unconjugated (NB100-64796), Biotin (NB100-63701) FITC (NB100-63703) and R-Phycoerythrin (NB100-63704) formats. However, studies have shown this clone partially blocks the proliferative response of antigen-specific CD4+ T cells when exposed to the antigen and cells expressing it, so for functional studies an alternative is recommended.

Novus Biologicals offers CD31/PECAM1 reagents for your research needs including:

• CD31/PECAM1 primary antibodies
• CD31/PECAM1 lysates
• CD31/PECAM1 peptides and proteins
• CD31/PECAM1 antibody pairs
• CD31/PECAM1 RNAi
• CD31/PECAM1 ELISA kits