Stem Cells

Increasing evidence shows that a variety of cancers arise from the transformation of normal stem cells into cancer stem cells (CSCs). CSCs are thought to sustain cancer progression, invasion, metastasis.

Epigenetic alterations have come to prominence in biomedical research. In particular, hypermethylation of CpG islands located in the promoter regions of tumor-suppressor genes is now firmly established as an important mechanism for gene inactivation in cancer.

Monocyte Chemotactic Protein-1 (MCP-1), also known as Chemokine C-C motif Ligand 2 (CCL2), is a small cytokine involved in immune response, inflammation and tissue repair. Specifically, MCP1 is responsible for recruiting monocytes, memory T cells, and dendritic cells to sites of tissue injury or infection. MCP-1 is produced by a wide range of cell types as a reaction to diverse inflammatory stimuli, and has been implicated in many diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis and atherosclerosis.

WW domain-containing transcription regulator protein 1 also known as WWTR1 and TAZ, is a 44KDa protein that acts as a downstream regulatory target in the Hippo signaling pathway. This protein undergoes post-translational modification and becomes phosphorylated by LATS2 and STK3/MST2. TAZ in its phosphorylated state is functionally inactive and is retained in the cytoplasm. When TAZ is not phosphorylated it can be retained in the nucleus by a protein called MED15.

Embryonic stem (ES) cells are cells derived from the inner cell mass of the blastocyst, an early-stage embryo. ES cells are distinguished from other cells due to their pluripotency, which is the ability to differentiate into any different type of cell in the body, and also their capability of propagating indefinitely. These two factors make embryonic stem cells valuable tools in the scientific community, especially in regenerative medicine.

SOX2 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, which play a vital role in embryonic development. SOX2 antibody research has identified Sox2 as a key transcription factor in pluripotent stem cells. We at Novus Biologicals offer a number of top quality SOX2 products in our stem cell antibody catalog.

The Sox2 antibody is widely used in sensory, neuroscience and stem cell marker research. Recently, Sox2 antibody preparations identified the Sox2 protein as a marker for malignant neural gliomas. We at Novus Biologicals offer a wide variety of highly validated Sox2 antibodies.

There are three human isoforms of the AKT gene, which plays a key role in several signalling pathways.

In December 2009, researchers at the University of Southern California cited using Novus’ mouse monoclonal Telomerase Reverse Transcriptase Antibody (cat# NB100-317) [PMID: 19923445]. Specifically, Novus’ hTERT antibody was used for immunofluorescent staining on human gingiva-derived mesenchymal stem cells (GMSC).

C-Myc is a widely expressed transcription factor, regulating cellular differentiation, proliferation, cell cycle progression and pro-apoptotic gene expression. The c-Myc antibody is widely used in cancer research, as a number of human tumors have been attributed to altered c-Myc expression.