RelA/NFkB p65 Antibody

NFkB is a pleiotropic transcription factor which exists as homodimeric/heterodimeric complex generated by Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 , and years of research has established that p65-p50 complex is most abundant in various cell types. The dimers bind at kB sites in their target genes DNA and the individual dimers exhibits differential affinity/specificity for acting as transcriptional activators or repressors e.g. p65-p50 and p65-c-Rel dimers acts transcriptional activators. Inside cytoplasm, NFkB complexes are held in an inactive state complexed with NFkB inhibitor or IkB family members which gets phosphorylated through IKKs/IkB kinases in response to different activators, subsequently degraded thus liberating the active NFkB complex which translocates to the nucleus for modulating the target genes. NFkB it has been found as the endpoint of a series of signaling events which are initiated by a diverse array of stimuli associated with critical cellular processes such as inflammation, immunity, differentiation, cell growth, apoptosis and tumorigenesis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 4 of 4.

Publications using NBP1-96139	Applications	Species
Lee JA, Kim HR, Kim J et al. The Novel Neuroprotective Compound KMS99220 Has an Early Anti-neuroinflammatory Effect via AMPK and HO-1, Independent of Nrf2. Exp Neurobiol. 2018-10-01 [PMID: 30429650] (WB, Mouse)	WB	Mouse
Jiang W, Zheng B, Zhang XH et al. Tongxinluo inhibits neointimal formation by regulating the expression and post-translational modification of KLF5 in macrophages. Am J Transl Res. 2016-12-01 [PMID: 27904679] (WB, Mouse)	WB	Mouse
Yang Z, Zheng B, Zhang Y et al. miR-155-dependent regulation of mammalian sterile 20-like kinase 2 (MST2) coordinates inflammation, oxidative stress and proliferation in vascular smooth muscle cells Biochim. Biophys. Acta 2015-04-17 [PMID: 25892184] (WB, Mouse)	WB	Mouse
Garraway SM, Woller SA, Huie JR et al. Peripheral noxious stimulation reduces withdrawal threshold to mechanical stimuli after spinal cord injury: role of tumor necrosis factor alpha and apoptosis. Pain 2014-11-01 [PMID: 25180012]

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Verified Customer	WB	Human	01/07/2015	View Summary Application Western Blot Sample Tested H1299 whole cell lysate Species Human

Array NBP1-96139

• RelA/NFkB p65 Antibodies
• RelA/NFkB p65 Antibody Pack
• RelA/NFkB p65 ELISA Kits
• RelA/NFkB p65 Inhibitors
• RelA/NFkB p65 Kit
• RelA/NFkB p65 Lysate
• RelA/NFkB p65 Proteins