RelA/NFkB p65 Antibody

NFkB is a pleiotropic transcription factor which exists as homodimeric/heterodimeric complex generated by Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 , and years of research has established that p65-p50 complex is most abundant in various cell types. The dimers bind at kB sites in their target genes DNA and the individual dimers exhibits differential affinity/specificity for acting as transcriptional activators or repressors e.g. p65-p50 and p65-c-Rel dimers acts transcriptional activators. Inside cytoplasm, NFkB complexes are held in an inactive state complexed with NFkB inhibitor or IkB family members which gets phosphorylated through IKKs/IkB kinases in response to different activators, subsequently degraded thus liberating the active NFkB complex which translocates to the nucleus for modulating the target genes. NFkB it has been found as the endpoint of a series of signaling events which are initiated by a diverse array of stimuli associated with critical cellular processes such as inflammation, immunity, differentiation, cell growth, apoptosis and tumorigenesis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NBP1-96138

• RelA/NFkB p65 Antibodies
• RelA/NFkB p65 Antibody Pack
• RelA/NFkB p65 ELISA Kits
• RelA/NFkB p65 Inhibitors
• RelA/NFkB p65 Kit
• RelA/NFkB p65 Lysate
• RelA/NFkB p65 Proteins